Thakkar JP, Prabhu VC, Rouse S, Lukas RV. Acute neurological complications of brain tumors and immune therapies, a guideline for the Neuro-hospitalist. Curr Neurol Neurosci Rep. 2020;20(8):32.

PubMed  Google Scholar 

Benedetti C. Supportive care in cancer: a general overview. Oncol (Williston Park). 2003;17(2 Suppl 2):7–8.

Google Scholar 

Makale MT, McDonald CR, Hattangadi-Gluth JA, Kesari S. Mechanisms of radiotherapy-associated cognitive disability in patients with brain tumours. Nat Rev Neurol. 2017;13(1):52–64.

CAS  PubMed  Google Scholar 

Meyers CA, Smith JA, Bezjak A, Mehta MP, Liebmann J, Illidge T, et al. Neurocognitive function and progression in patients with brain metastases treated with whole-brain radiation and motexafin gadolinium: results of a randomized phase III trial. J Clin Oncol. 2004;22(1):157–65.

CAS  PubMed  Google Scholar 

Acharya S, Wu S, Ashford JM, Tinkle CL, Lucas JT, Qaddoumi I, et al. Association between hippocampal dose and memory in survivors of childhood or adolescent low-grade glioma: a 10-year neurocognitive longitudinal study. Neuro Oncol. 2019;21(9):1175–83.

PubMed  PubMed Central  Google Scholar 

Brown PD, Jaeckle K, Ballman KV, Farace E, Cerhan JH, Anderson SK, et al. Effect of radiosurgery alone vs radiosurgery with whole brain radiation therapy on cognitive function in patients with 1 to 3 brain metastases: A randomized clinical trial. JAMA. 2016;316(4):401–9.

PubMed  PubMed Central  Google Scholar 

Chang EL, Wefel JS, Hess KR, Allen PK, Lang FF, Kornguth DG, et al. Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial. Lancet Oncol. 2009;10(11):1037–44.

PubMed  Google Scholar 

Dietrich J, Monje M, Wefel J, Meyers C. Clinical patterns and biological correlates of cognitive dysfunction associated with cancer therapy. Oncologist. 2008;13(12):1285–95.

PubMed  Google Scholar 

Wefel JS, Schagen SB. Chemotherapy-related cognitive dysfunction. Curr Neurol Neurosci Rep. 2012;12(3):267–75.

CAS  PubMed  Google Scholar 

Monje M, Dietrich J. Cognitive side effects of cancer therapy demonstrate a functional role for adult neurogenesis. Behav Brain Res. 2012;227(2):376–9.

PubMed  Google Scholar 

Monje ML, Mizumatsu S, Fike JR, Palmer TD. Irradiation induces neural precursor-cell dysfunction. Nat Med. 2002;8(9):955–62.

CAS  PubMed  Google Scholar 

Hellstrom NA, Bjork-Eriksson T, Blomgren K, Kuhn HG. Differential recovery of neural stem cells in the subventricular zone and dentate gyrus after ionizing radiation. Stem Cells. 2009;27(3):634–41.

PubMed  Google Scholar 

Monje ML, Toda H, Palmer TD. Inflammatory Blockade restores adult hippocampal neurogenesis. Science. 2003;302(5651):1760–5.

CAS  PubMed  Google Scholar 

Dietrich J, Han R, Yang Y, Mayer-Proschel M, Noble M. CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo. J Biol. 2006;5(7):22.

PubMed  PubMed Central  Google Scholar 

Morris GM, Hopewell JW, Morris AD. A comparison of the effects of methotrexate and misonidazole on the germinal cells of the subependymal plate of the rat. Br J Radiol. 1995;68(808):406–12.

CAS  PubMed  Google Scholar 

Rzeski W, Pruskil S, Macke A, Felderhoff-Mueser U, Reiher AK, Hoerster F, et al. Anticancer agents are potent neurotoxins in vitro and in vivo. Ann Neurol. 2004;56(3):351–60.

CAS  PubMed  Google Scholar 

Muto J, Dezamis E, Rigaux-Viode O, Peeters S, Roux A, Zanello M, et al. Functional-Based resection does not worsen quality of life in patients with a diffuse Low-Grade glioma involving eloquent brain regions: A prospective cohort study. World Neurosurg. 2018;113:e200–12.

PubMed  Google Scholar 

Motomura K, Chalise L, Ohka F, Aoki K, Tanahashi K, Hirano M, et al. Neurocognitive and functional outcomes in patients with diffuse frontal lower-grade gliomas undergoing intraoperative awake brain mapping. J Neurosurg. 2020;132(6):1683–91.

PubMed  Google Scholar 

Jalali R, Gupta T, Goda JS, Goswami S, Shah N, Dutta D, et al. Efficacy of stereotactic conformal radiotherapy vs conventional radiotherapy on benign and Low-Grade brain tumors: A randomized clinical trial. JAMA Oncol. 2017;3(10):1368–76.

PubMed  PubMed Central  Google Scholar 

Jaspers J, Mendez Romero A, van den Hoogeman MS, Wiggenraad RGJ, Taphoorn MJB, et al. Evaluation of the hippocampal normal tissue complication model in a prospective cohort of low grade glioma Patients-An analysis within the EORTC 22033 clinical trial. Front Oncol. 2019;9:991.

PubMed  PubMed Central  Google Scholar 

Gondi V, Hermann BP, Mehta MP, Tome WA. Hippocampal dosimetry predicts neurocognitive function impairment after fractionated stereotactic radiotherapy for benign or low-grade adult brain tumors. Int J Radiat Oncol Biol Phys. 2012;83(4):e487–93.

PubMed  Google Scholar 

Goda JS, Dutta D, Krishna U, Goswami S, Kothavade V, Kannan S, et al. Hippocampal radiotherapy dose constraints for predicting long-term neurocognitive outcomes: mature data from a prospective trial in young patients with brain tumors. Neuro Oncol. 2020;22(11):1677–85.

CAS  PubMed  PubMed Central  Google Scholar 

Brown PD, Pugh S, Laack NN, Wefel JS, Khuntia D, Meyers C, et al. Memantine for the prevention of cognitive dysfunction in patients receiving whole-brain radiotherapy: a randomized, double-blind, placebo-controlled trial. Neuro Oncol. 2013;15(10):1429–37.

CAS  PubMed  PubMed Central  Google Scholar 

Gondi V, Pugh SL, Tome WA, Caine C, Corn B, Kanner A, et al. Preservation of memory with conformal avoidance of the hippocampal neural stem-cell compartment during whole-brain radiotherapy for brain metastases (RTOG 0933): a phase II multi-institutional trial. J Clin Oncol. 2014;32(34):3810–6.

PubMed  PubMed Central  Google Scholar 

Brown PD, Gondi V, Pugh S, Tome WA, Wefel JS, Armstrong TS, et al. Hippocampal avoidance during Whole-Brain radiotherapy plus memantine for patients with brain metastases: phase III trial NRG oncology CC001. J Clin Oncol. 2020;38(10):1019–29.

PubMed  PubMed Central  Google Scholar 

Brown PD, Chung C, Liu DD, McAvoy S, Grosshans D, Al Feghali K, et al. A prospective phase II randomized trial of proton radiotherapy vs intensity-modulated radiotherapy for patients with newly diagnosed glioblastoma. Neuro Oncol. 2021;23(8):1337–47.

PubMed  PubMed Central  Google Scholar 

Rapp SR, Case LD, Peiffer A, Naughton MM, Chan MD, Stieber VW, et al. Donepezil for irradiated brain tumor survivors: A phase III randomized Placebo-Controlled clinical trial. J Clin Oncol. 2015;33(15):1653–9.

CAS  PubMed  PubMed Central  Google Scholar 

Correa DD, Kryza-Lacombe M, Baser RE, Beal K, DeAngelis LM. Cognitive effects of donepezil therapy in patients with brain tumors: a pilot study. J Neurooncol. 2016;127(2):313–9.

CAS  PubMed  PubMed Central  Google Scholar 

Meyers CA, Weitzner MA, Valentine AD, Levin VA. Methylphenidate therapy improves cognition, mood, and function of brain tumor patients. J Clin Oncol. 1998;16(7):2522–7.

CAS  PubMed  Google Scholar 

Gehring K, Patwardhan SY, Collins R, Groves MD, Etzel CJ, Meyers CA, et al. A randomized trial on the efficacy of methylphenidate and modafinil for improving cognitive functioning and symptoms in patients with a primary brain tumor. J Neurooncol. 2012;107(1):165–74.

CAS  PubMed  Google Scholar 

van der Coomans MB, Gehring K, Taphoorn MJB. Treatment of cognitive deficits in brain tumour patients: current status and future directions. Curr Opin Oncol. 2019;31(6):540–7.

PubMed  PubMed Central  Google Scholar 

Hassler MR, Elandt K, Preusser M, Lehrner J, Binder P, Dieckmann K, et al. Neurocognitive training in patients with high-grade glioma: a pilot study. J Neurooncol. 2010;97(1):109–15.

PubMed  Google Scholar 

Zucchella C, Capone A, Codella V, De Nunzio AM, Vecchione C, Sandrini G, et al. Cognitive rehabilitation for early post-surgery inpatients affected by primary brain tumor: a randomized, controlled trial. J Neurooncol. 2013;114(1):93–100.

CAS  PubMed  Google Scholar 

Maschio M, Dinapoli L, Fabi A, Giannarelli D, Cantelmi T. Cognitive rehabilitation training in patients with brain tumor-related epilepsy and cognitive deficits: a pilot study. J Neurooncol. 2015;125(2):419–26.

PubMed  Google Scholar 

Richard NM, Bernstein LJ, Mason WP, Laperriere N, Maurice C, Millar BA, et al. Cognitive rehabilitation for executive dysfunction in brain tumor patients: a pilot randomized controlled trial. J Neurooncol. 2019;142(3):565–75.

PubMed  Google Scholar 

Sanders SL, Bantum EO, Owen JE, Thornton AA, Stanton AL. Supportive care needs in patients with lung cancer. Psychooncology. 2010;19(5):480–9.

PubMed  Google Scholar 

Brown PD, Ballman KV, Rummans TA, Maurer MJ, Sloan JA, Boeve BF, et al. Prospective study of quality of life in adults with newly diagnosed high-grade gliomas. J Neurooncol. 2006;76(3):283–91.

PubMed  Google Scholar 

Lovely MP, Miaskowski C, Dodd M. Relationship between fatigue and quality of life in patients with glioblastoma multiformae. Oncol Nurs Forum. 1999;26(5):921–5.

CAS  PubMed