Brindley PJ, Bachini M, Ilyas SI, Khan SA, Loukas A, Sirica AE, Teh BT, Wongkham S, Gores GJ. Cholangiocarcinoma. Nat Rev Dis Primers. 2021;7(1):65. https://doi.org/10.1038/s41572-021-00300-2.

Article  PubMed  PubMed Central  Google Scholar 

Razumilava N, Gores GJ. Cholangiocarcinoma. Lancet. 2014;383(9935):2168–79. https://doi.org/10.1016/s0140-6736(13)61903-0.

Article  PubMed  PubMed Central  Google Scholar 

Cardinale V, Bragazzi MC, Carpino G, Torrice A, Fraveto A, Gentile R, Pasqualino V, Melandro F, Aliberti C, Bastianelli C, et al. Cholangiocarcinoma: increasing burden of classifications. Hepatobiliary Surg Nutr. 2013;2(5):272–80. https://doi.org/10.3978/j.issn.2304-3881.2013.10.02.

Article  PubMed  PubMed Central  Google Scholar 

Anderson NL, Anderson NG. The human plasma proteome: history, character, and diagnostic prospects. Mol Cell Proteomics. 2002;1(11):845–67. https://doi.org/10.1074/mcp.r200007-mcp200.

Article  CAS  PubMed  Google Scholar 

Bonney GK, Craven RA, Prasad R, Melcher AF, Selby PJ, Banks RE. Circulating markers of biliary malignancy: opportunities in proteomics? Lancet Oncol. 2008;9(2):149–58. https://doi.org/10.1016/s1470-2045(08)70027-5.

Article  CAS  PubMed  Google Scholar 

Ferkingstad E, Sulem P, Atlason BA, Sveinbjornsson G, Magnusson MI, Styrmisdottir EL, Gunnarsdottir K, Helgason A, Oddsson A, Halldorsson BV, et al. Large-scale integration of the plasma proteome with genetics and disease. Nat Genet. 2021;53(12):1712–21. https://doi.org/10.1038/s41588-021-00978-w.

Article  CAS  PubMed  Google Scholar 

Jiang L, Zheng Z, Fang H, Yang J. A generalized linear mixed model association tool for biobank-scale data. Nat Genet. 2021;53(11):1616–21. https://doi.org/10.1038/s41588-021-00954-4.

Article  CAS  PubMed  Google Scholar 

Sun J, Zhao J, Jiang F, Wang L, Xiao Q, Han F, Chen J, Yuan S, Wei J, Larsson SC, et al. Identification of novel protein biomarkers and drug targets for colorectal cancer by integrating human plasma proteome with genome. Genome Med. 2023;15(1):75. https://doi.org/10.1186/s13073-023-01229-9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang K, Yi H, Wang Y, Jin D, Zhang G, Mao Y. Proteome-wide multicenter Mendelian randomization analysis to identify novel therapeutic targets for lung cancer. Arch Bronconeumol. 2024;60(9):553–8. https://doi.org/10.1016/j.arbres.2024.05.007.

Article  PubMed  Google Scholar 

Ren F, Jin Q, Liu T, Ren X, Zhan Y. Proteome-wide mendelian randomization study implicates therapeutic targets in common cancers. J Transl Med. 2023;21(1):646. https://doi.org/10.1186/s12967-023-04525-5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Considine DPC, Jia G, Shu X, Schildkraut JM, Pharoah PDP, Zheng W, Kar SP. Genetically predicted circulating protein biomarkers and ovarian cancer risk. Gynecol Oncol. 2021;160(2):506–13. https://doi.org/10.1016/j.ygyno.2020.11.016.

Article  CAS  PubMed  Google Scholar 

Sun BB, Maranville JC, Peters JE, Stacey D, Staley JR, Blackshaw J, Burgess S, Jiang T, Paige E, Surendran P, et al. Genomic atlas of the human plasma proteome. Nature. 2018;558(7708):73–9. https://doi.org/10.1038/s41586-018-0175-2.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hemani G, Zheng J, Elsworth B, Wade KH, Haberland V, Baird D, Laurin C, Burgess S, Bowden J, Langdon R, et al. The MR-Base platform supports systematic causal inference across the human phenome. Elife. 2018;7. https://doi.org/10.7554/eLife.34408.

Ma L, Hernandez MO, Zhao Y, Mehta M, Tran B, Kelly M, Rae Z, Hernandez JM, Davis JL, Martin SP, et al. Tumor cell biodiversity drives microenvironmental reprogramming in liver cancer. Cancer Cell. 2019;36(4):418-430.e416. https://doi.org/10.1016/j.ccell.2019.08.007.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Butler A, Hoffman P, Smibert P, Papalexi E, Satija R. Integrating single-cell transcriptomic data across different conditions, technologies, and species. Nat Biotechnol. 2018;36(5):411–20. https://doi.org/10.1038/nbt.4096.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aran D, Looney AP, Liu L, Wu E, Fong V, Hsu A, Chak S, Naikawadi RP, Wolters PJ, Abate AR, et al. Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage. Nat Immunol. 2019;20(2):163–72. https://doi.org/10.1038/s41590-018-0276-y.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tang Z, Li C, Kang B, Gao G, Li C, Zhang Z. GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 2017;45(W1):W98-w102. https://doi.org/10.1093/nar/gkx247.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Y, Xiao J, Cai J, Li R, Sui X, Zhang J, Lu T, Chen H, Chen G, Li H, et al. Single-cell immune profiling of mouse liver aging reveals Cxcl2+ macrophages recruit neutrophils to aggravate liver injury. Hepatology. 2024;79(3):589–605. https://doi.org/10.1097/hep.0000000000000590.

Article  PubMed  Google Scholar 

Jamann H, Desu HL, Cui QL, Halaweh A, Tastet O, Klement W, Zandee S, Pernin F, Mamane VH, Ouédraogo O, et al. ALCAM on human oligodendrocytes mediates CD4 T cell adhesion. Brain. 2024;147(1):147–62. https://doi.org/10.1093/brain/awad286.

Article  PubMed  Google Scholar 

Chen S, Huang W, Wan Q, Tang Z, Li X, Zeng F, Zheng S, Li Z, Liu X. Investigation of the acute pathogenesis of spondyloarthritis/HLA-B27-associated anterior uveitis based on genome-wide association analysis and single-cell transcriptomics. J Transl Med. 2024;22(1):271. https://doi.org/10.1186/s12967-024-05077-y.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun Z, Yun Z, Lin J, Sun X, Wang Q, Duan J, Li C, Zhang X, Xu S, Wang Z, et al. Comprehensive mendelian randomization analysis of plasma proteomics to identify new therapeutic targets for the treatment of coronary heart disease and myocardial infarction. J Transl Med. 2024;22(1):404. https://doi.org/10.1186/s12967-024-05178-8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou S, Tao B, Guo Y, Gu J, Li H, Zou C, Tang S, Jiang S, Fu D, Li J. Integrating plasma protein-centric multi-omics to identify potential therapeutic targets for pancreatic cancer. J Transl Med. 2024;22(1):557. https://doi.org/10.1186/s12967-024-05363-9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jin Y, Lei Z, Li P, Lyu G. Proteome-wide Mendelian randomization and single-cell sequencing analysis identify the association between plasma proteins and gastric cancer. J Gastrointest Oncol. 2024;15(4):1464–74. https://doi.org/10.21037/jgo-24-200.

Article  PubMed  PubMed Central  Google Scholar 

Lindner I, Hemdan NY, Buchold M, Huse K, Bigl M, Oerlecke I, Ricken A, Gaunitz F, Sack U, Naumann A, et al. Alpha2-macroglobulin inhibits the malignant properties of astrocytoma cells by impeding beta-catenin signaling. Cancer Res. 2010;70(1):277–87. https://doi.org/10.1158/0008-5472.Can-09-1462.

Article  CAS  PubMed  Google Scholar 

Kurz S, Thieme R, Amberg R, Groth M, Jahnke HG, Pieroh P, Horn LC, Kolb M, Huse K, Platzer M, et al. Correction: The anti-tumorigenic activity of A2M-A lesson from the naked mole-rat. PLoS One. 2018;13(3):e0195169. https://doi.org/10.1371/journal.pone.0195169.

Article  PubMed  PubMed Central  Google Scholar 

Qiang Y, Wang F, Yan S, Zhang H, Zhu L, Chen Z, Tu F, Wang D, Wang G, Wang W, et al. Abnormal expression of Forkhead Box J2 (FOXJ2) suppresses migration and invasion in extrahepatic cholangiocarcinoma and is associated with prognosis. Int J Oncol. 2015;46(6):2449–58. https://doi.org/10.3892/ijo.2015.2957.

Article  CAS  PubMed  Google Scholar 

Zhang Z, Meng G, Wang L, Ma Y, Guan Z. The prognostic role and reduced expression of FOXJ2 in human hepatocellular carcinoma. Mol Med Rep. 2016;14(1):2