Misdiagnosis of Suspected Cancer in Pancreatoduodenectomy: A Systematic Review and Prevalence Mata-Analysis

Zhang L, Sanagapalli S, Stoita A. Challenges in diagnosis of pancreatic cancer. World J Gastroenterol. 2018;24(19):2047–60.

Article  PubMed  PubMed Central  Google Scholar 

European Study Group on Cystic Tumours of the Pancreas. European evidence-based guidelines on pancreatic cystic neoplasms. Gut. 2018;67(5):789–804.

Singhi AD, Koay EJ, Chari ST, Maitra A. Early detection of pancreatic cancer: opportunities and challenges. Gastroenterology. 2019;156(7):2024–40.

Article  PubMed  Google Scholar 

Cazacu IM, Chavez AAL, Saftoiu A, Whitlow TG, Bhosale P, Bhutani MS. A diagnostic challenge: pancreatic cancer or autoimmune pancreatitis? Curr Health Sci J. 2018;44(2):181–5.

CAS  PubMed  PubMed Central  Google Scholar 

Swords DS, Mone MC, Zhang C, Presson AP, Mulvihill SJ, Scaife CL. Initial misdiagnosis of proximal pancreatic adenocarcinoma is associated with delay in diagnosis and advanced stage at presentation. J Gastrointest Surg Off J Soc Surg Aliment Tract. 2015;19(10):1813–21.

Article  Google Scholar 

Gerritsen A, Molenaar IQ, Bollen TL, Nio CY, Dijkgraaf MG, van Santvoort HC, et al. Preoperative characteristics of patients with presumed pancreatic cancer but ultimately benign disease: a multicenter series of 344 pancreatoduodenectomies. Ann Surg Oncol. 2014;21(12):3999–4006.

Article  PubMed  Google Scholar 

van Roessel S, Soer EC, Daamen LA, van Dalen D, Fariña Sarasqueta A, Stommel MWJ, et al. Preoperative misdiagnosis of pancreatic and periampullary cancer in patients undergoing pancreatoduodenectomy: a multicentre retrospective cohort study. Eur J Surg Oncol. 2021;47(10):2525–32.

Article  PubMed  Google Scholar 

Paiella S, Secchettin E, Lionetto G, Archibugi L, Azzolina D, Casciani F, et al. Surveillance of individuals at high risk of developing pancreatic cancer: a prevalence meta-analysis to estimate the rate of low-yield surgery. Ann Surg. 2024;279(1):37–44.

Article  PubMed  Google Scholar 

Hajibandeh S, Hajibandeh S, Intrator C, Hassan K, Sehmbhi M, Shah J, et al. Neoadjuvant chemoradiotherapy versus immediate surgery for resectable and borderline resectable pancreatic cancer: meta-analysis and trial sequential analysis of randomized controlled trials. Ann Hepato-Biliary-Pancreat Surg. 2023;27(1):28–39.

Article  Google Scholar 

PancreasGroup.org Collaborative. Pancreatic surgery outcomes: multicentre prospective snapshot study in 67 countries. Br J Surg. 202;111(1):znad330.

Narayanan S, Martin AN, Turrentine FE, Bauer TW, Adams RB, Zaydfudim VM. Mortality after pancreaticoduodenectomy: assessing early and late causes of patient death. J Surg Res. 2018;231:304–8.

Article  PubMed  PubMed Central  Google Scholar 

Santema TB, Visser A, Busch ORC, Dijkgraaf MGW, Goslings JC, Gouma DJ, et al. Hospital costs of complications after a pancreatoduodenectomy. HPB. 2015;17(8):723–31.

Article  PubMed  PubMed Central  Google Scholar 

Pușcașu CI, Rimbaş M, Mateescu RB, Larghi A, Cauni V. Advances in the diagnosis of pancreatic cystic lesions. Diagnostics. 2022;12(8):1779.

Article  PubMed  PubMed Central  Google Scholar 

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;29(372):n71.

Article  Google Scholar 

Ottawa Hospital Research Institute [Internet]. [cited 2024 Aug 27]. Available from: https://www.ohri.ca/programs/clinical_epidemiology/oxford.asp

Luo D, Wan X, Liu J, Tong T. Optimally estimating the sample mean from the sample size, median, mid-range, and/or mid-quartile range. Stat Methods Med Res. 2018;27(6):1785–805.

Article  PubMed  Google Scholar 

Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315(7109):629–34.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Martin FM. Clinical and pathologic correlations in patients with periampullary tumors. Arch Surg. 1990;125(6):723.

Article  CAS  PubMed  Google Scholar 

Smith CD, Behrns KE, van Heerden JA, Sarr MG. Radical pancreatoduodenectomy for misdiagnosed pancreatic mass. Br J Surg. 1994;81(4):585–9.

Article  CAS  PubMed  Google Scholar 

Van Gulik TM, Reeders JWAJ, Bosma A, Moojen TM, Smits NJ, Allema JH, et al. Incidence and clinical findings of benign, inflammatory disease in patients resected for presumed pancreatic head cancer. Gastrointest Endosc. 1997;46(5):417–23.

Article  PubMed  Google Scholar 

Böttger TC, Junginger T. Treatment of tumors of the pancreatic head with suspected but unproved malignancy: is a nihilistic approach justified? World J Surg. 1999;23(2):158–63.

Article  PubMed  Google Scholar 

Abraham SC, Wilentz RE, Yeo CJ, Sohn TA, Cameron JL, Boitnott JK, et al. Pancreaticoduodenectomy (Whipple resections) in patients without malignancy: are they all `chronic pancreatitis’? Am J Surg Pathol. 2003;27(1):110–20.

Article  PubMed  Google Scholar 

Camp ER, Vogel SB. Blind Whipple resections for periampullary and pancreatic lesions. Am Surg. 2004;70(1):6–12.

Article  PubMed  Google Scholar 

Kennedy T, Preczewski L, Stocker SJ, Rao SM, Parsons WG, Wayne JD, et al. Incidence of benign inflammatory disease in patients undergoing Whipple procedure for clinically suspected carcinoma: a single-institution experience. Am J Surg. 2006;191(3):437–41.

Article  PubMed  Google Scholar 

Sasson AR, Gulizia JM, Galva A, Anderson J, Thompson J. Pancreaticoduodenectomy for suspected malignancy: have advancements in radiographic imaging improved results? Am J Surg. 2006;192(6):888–93.

Article  PubMed  Google Scholar 

Kavanagh DO, O’Riain C, Ridgway PF, Neary P, Crotty TC, Geoghegan JG, et al. Radical pancreaticoduodenectomy for benign disease. Sci World J. 2008;8:1156–67.

Article  CAS  Google Scholar 

De La Fuente SG, Ceppa EP, Reddy SK, Clary BM, Tyler DS, Pappas TN. Incidence of benign disease in patients that underwent resection for presumed pancreatic cancer diagnosed by endoscopic ultrasonography (EUS) and fine-needle aspiration (FNA). J Gastrointest Surg. 2010;14(7):1139–42.

Article  PubMed  Google Scholar 

De Castro SMM, De Nes LCF, Nio CY, Velseboer DC, Kate FJWT, Busch ORC, et al. Incidence and characteristics of chronic and lymphoplasmacytic sclerosing pancreatitis in patients scheduled to undergo a pancreatoduodenectomy. HPB. 2010;12(1):15–21.

Article  PubMed  PubMed Central  Google Scholar 

Hernandez J, Morton C, Clark W, Mullinax J, Mathur A, Marcadis A, et al. Pancreaticoduodenectomy for suspected periampullary cancers: the mimes of malignancy. HPB. 2009;11(7):578–84.

Article  PubMed  PubMed Central  Google Scholar 

Manzia TM, Toti L, Lenci I, Attia M, Tariciotti L, Bramhall SR, et al. Benign disease and unexpected histological findings after pancreaticoduodenectomy: the role of endoscopic ultrasound fine needle aspiration. Ann R Coll Surg Engl. 2010;92(4):295–301.

Article  PubMed  PubMed Central  Google Scholar 

Hurtuk MG, Shoup M, Oshima K, Yong S, Aranha GV. Pancreaticoduodenectomies in patients without periampullary neoplasms: lesions that masquerade as cancer. Am J Surg. 2010;199(3):372–6.

Article  PubMed  Google Scholar 

Garcea G, Metcalfe MS, Berry DP, Robertson GS, Lloyd DM, Dennison AR. Is intraoperative confirmation of malignancy during pancreaticoduodenectomy mandatory? J Gastrointest Surg. 2012;16(2):370–5.

Article  PubMed  Google Scholar 

Van Heerde MJ, Biermann K, Zondervan PE, Kazemier G, Van Eijck CHJ, Pek C, et al. Prevalence of autoimmune pancreatitis and other benign disorders in pancreatoduodenectomy for presumed malignancy of the pancreatic head. Dig Dis Sci. 2012;57(9):2458–65.

Article  PubMed  PubMed Central  Google Scholar 

Yarandi SS, Runge T, Wang L, Liu Z, Jiang Y, Chawla S, et al. Increased incidence of benign pancreatic pathology following pancreaticoduodenectomy for presumed malignancy over 10 years despite increased use of endoscopic ultrasound. Diagn Ther Endosc. 2014;5(2014):1–6.

Article  Google Scholar 

Gomes RM, Bal M, Patkar S, Goel M, Shrikhande SV. Unexpected benign histopathology after pancreatoduodenectomy for presumed malignancy: accepting the inevitable. Langenbecks Arch Surg. 2016;401(2):169–79.

Article  PubMed  Google Scholar 

Byrling J, Ghazi S, Andersson B. Tumour origin, diagnostic accuracy and histopathological evaluation in patients with periampullary cancer: nationwide cohort study. BJS Open. 2023;7(5):zrad104.

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