Injectable nanocomposite hydrogels for targeted intervention in cancer, wound healing, and bone and myocardial tissue engineering

Zugazagoitia J, Guedes C, Ponce S, Ferrer I, Molina-Pinelo S, Paz-Ares L. Current challenges in cancer treatment. Clin Ther. 2016;38:1551–66. https://doi.org/10.1016/j.clinthera.2016.03.026.

Article  PubMed  Google Scholar 

Khan SU, Fatima K, Aisha S, Malik F. Unveiling the mechanisms and challenges of cancer drug resistance. Cell Commun Signaling. 2024;22:109. https://doi.org/10.1186/s12964-023-01302-1.

Article  Google Scholar 

Frykberg RG, Banks J. Challenges in the treatment of chronic wounds. Adv Wound Care (New Rochelle). 2015;4:560–82. https://doi.org/10.1089/wound.2015.0635.

Article  PubMed  Google Scholar 

Ding X, Tang Q, Xu Z, Xu Y, Zhang H, Zheng D, Wang S, Tan Q, Maitz J, Maitz PK, Yin S, Wang Y, Chen J. Challenges and innovations in treating chronic and acute wound infections: from basic science to clinical practice. Burns Trauma. 2022;10:tkac14. https://doi.org/10.1093/burnst/tkac014.

Article  Google Scholar 

Mamidi N, Ijadi F, Norahan MH. Leveraging the recent advancements in GelMA scaffolds for bone tissue engineering: an assessment of challenges and opportunities. Biomacromol. 2024;25:2075–113. https://doi.org/10.1021/acs.biomac.3c00279.

Article  CAS  Google Scholar 

Zhu T, Zhou H, Chen X, Zhu Y. Recent advances of responsive scaffolds in bone tissue engineering. Front Bioeng Biotechnol. 2023;11:1296881. https://doi.org/10.3389/fbioe.2023.1296881.

Article  PubMed  PubMed Central  Google Scholar 

Zhuang RZ, Lock R, Liu B, Vunjak-Novakovic G. Opportunities and challenges in cardiac tissue engineering from an analysis of two decades of advances. Nat Biomed Eng. 2022;6:327–38. https://doi.org/10.1038/s41551-022-00885-3.

Article  PubMed  Google Scholar 

Qasim M, Arunkumar P, Powell HM, Khan M. Current research trends and challenges in tissue engineering for mending broken hearts. Life Sci. 2019;229:233–50. https://doi.org/10.1016/j.lfs.2019.05.012.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Caló E, Khutoryanskiy VV. Biomedical applications of hydrogels: A review of patents and commercial products. Eur Polym J. 2015;65:252–67. https://doi.org/10.1016/j.eurpolymj.2014.11.024.

Article  CAS  Google Scholar 

Pires PC, Renca A, Amaro I, Parreiras L, Anselmo M, Ferreira M, Veiga F, Paiva-Santos AC. From stimuli-responsive polymers to nanosystems and electrocircuits: An update on the current state of polymeric hydrogel microneedles for wound healing. J Drug Deliv Sci Technol. 2024;102: 106395. https://doi.org/10.1016/j.jddst.2024.106395.

Article  CAS  Google Scholar 

Kumi M, Ejeromedoghene O, Sudane WD, Zhang Z. Unlocking the biological response of smart Stimuli-Responsive hydrogels and their application in biological systems. Eur Polym J. 2024;209:112906. https://doi.org/10.1016/j.eurpolymj.2024.112906.

Article  CAS  Google Scholar 

Cha GD, Lee WH, Sunwoo S-H, Kang D, Kang T, Cho KW, Kim M, Park OK, Jung D, Lee J, Choi SH, Hyeon T, Kim D-H. Multifunctional injectable hydrogel for In vivo diagnostic and therapeutic applications. ACS Nano. 2022;16:554–67. https://doi.org/10.1021/acsnano.1c07649.

Article  CAS  PubMed  Google Scholar 

Duarte J, Mascarenhas-Melo F, Pires PC, Veiga F, Paiva-Santos AC. Multifunctional hydrogels-based therapies for chronic diabetic wound healing. Eur Polym J. 2024;211: 113026. https://doi.org/10.1016/j.eurpolymj.2024.113026.

Article  CAS  Google Scholar 

Xiao Z, Li Q, Liu H, Zhao Q, Niu Y, Zhao D. Adhesion mechanism and application progress of hydrogels. Eur Polym J. 2022;173:111277. https://doi.org/10.1016/j.eurpolymj.2022.111277.

Article  CAS  Google Scholar 

Pires PC, Mascarenhas-Melo F, Pedrosa K, Lopes D, Lopes J, Macário-Soares A, Peixoto D, Giram PS, Veiga F, Paiva-Santos AC. Polymer-based biomaterials for pharmaceutical and biomedical applications: A focus on topical drug administration. Eur Polym J. 2023;187:111868. https://doi.org/10.1016/j.eurpolymj.2023.111868.

Article  CAS  Google Scholar 

Yang Q, Peng J, Xiao H, Xu X, Qian Z. Polysaccharide hydrogels: Functionalization, construction and served as scaffold for tissue engineering. Carbohydr Polym. 2022;278: 118952. https://doi.org/10.1016/j.carbpol.2021.118952.

Article  CAS  PubMed  Google Scholar 

Zhao L, Zhou Y, Zhang J, Liang H, Chen X, Tan H. Natural polymer-based hydrogels: from polymer to biomedical applications. Pharmaceutics. 2023;15:2514. https://doi.org/10.3390/pharmaceutics15102514.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gyles DA, Castro LD, Silva JOC, Ribeiro-Costa RM. A review of the designs and prominent biomedical advances of natural and synthetic hydrogel formulations. Eur Polym J. 2017;88:373–92. https://doi.org/10.1016/j.eurpolymj.2017.01.027.

Article  CAS  Google Scholar 

Alexander A, Ajazuddin J, Khan S, Saraf S. Saraf, Polyethylene glycol (PEG)–Poly(N-isopropylacrylamide) (PNIPAAm) based thermosensitive injectable hydrogels for biomedical applications. Eur J Pharm Biopharm. 2014;88:575–85. https://doi.org/10.1016/j.ejpb.2014.07.005.

Article  CAS  PubMed  Google Scholar 

Dethe MR, Prabakaran A, Ahmed H, Agrawal M, Roy U, Alexander A. PCL-PEG copolymer based injectable thermosensitive hydrogels. J Controlled Release. 2022;343:217–36. https://doi.org/10.1016/j.jconrel.2022.01.035.

Article  CAS  Google Scholar 

Sghier K, Mur M, Veiga F, Paiva-Santos AC, Pires PC. Novel therapeutic hybrid systems using hydrogels and nanotechnology: a focus on nanoemulgels for the treatment of skin diseases. Gels. 2024;10:45. https://doi.org/10.3390/gels10010045.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gao Y, Liu Q, Kong W, Wang J, He L, Guo L, Lin H, Fan H, Fan Y, Zhang X. Activated hyaluronic acid/collagen composite hydrogel with tunable physical properties and improved biological properties. Int J Biol Macromol. 2020;164:2186–96. https://doi.org/10.1016/j.ijbiomac.2020.07.319.

Article  CAS  PubMed  Google Scholar 

Manasi EJ, Solanki R, Dhanka M, Thareja P, Bhatia D. Self-healing, injectable chitosan-based hydrogels: structure, properties and biological applications. Mater Adv. 2024;5:5365–93. https://doi.org/10.1039/D4MA00131A.

Article  Google Scholar 

Chang C, Zhang L. Cellulose-based hydrogels: Present status and application prospects. Carbohydr Polym. 2011;84:40–53. https://doi.org/10.1016/j.carbpol.2010.12.023.

Article  CAS  Google Scholar 

Sun L, Xu Y, Han Y, Cui J, Jing Z, Li D, Liu J, Xiao C, Li D, Cai B. Collagen-based hydrogels for cartilage regeneration. Orthop Surg. 2023;15:3026–45. https://doi.org/10.1111/os.13884.

Article  PubMed  PubMed Central  Google Scholar 

Chen I-C, Su C-Y, Chen P-Y, Hoang TC, Tsou Y-S, Fang H-W. Investigation and characterization of factors affecting rheological properties of poloxamer-based thermo-sensitive hydrogel. Polymers (Basel). 2022;14:5353. https://doi.org/10.3390/polym14245353.

Article  CAS  PubMed  Google Scholar 

Shitrit Y, Davidovich-Pinhas M, Bianco-Peled H. Shear thinning pectin hydrogels physically cross-linked with chitosan nanogels. Carbohydr Polym. 2019;225: 115249. https://doi.org/10.1016/j.carbpol.2019.115249.

Article  CAS  PubMed  Google Scholar 

Salma-Ancane K, Sceglovs A, Tracuma E, Wychowaniec JK, Aunina K, Ramata-Stunda A, Nikolajeva V, Loca D. Effect of crosslinking strategy on the biological, antibacterial and physicochemical performance of hyaluronic acid and ɛ-polylysine based hydrogels. Int J Biol Macromol. 2022;208:995–1008. https://doi.org/10.1016/j.ijbiomac.2022.03.207.

Article  CAS  PubMed  Google Scholar 

Li Z, Zhou Y, Li T, Zhang J, Tian H. Stimuli-responsive hydrogels: Fabrication and biomedical applications. View. 2022;3:20200112. https://doi.org/10.1002/VIW.20200112.

Article  CAS  Google Scholar 

Srivastava N, Choudhury AR. Stimuli-responsive polysaccharide-based smart hydrogels and their emerging applications. Ind Eng Chem Res. 2023;62:841–66. https://doi.org/10.1021/acs.iecr.2c02779.

Article 

Comments (0)

No login
gif