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Temperature and osmotic pressure dual-stimuli-responsive ophthalmic gels embedded with HPCD-modified nanoparticles for prolonged-release delivery of natamycin
Temperature and osmotic pressure dual-stimuli-responsive ophthalmic gels embedded with HPCD-modified nanoparticles for prolonged-release delivery of natamycin
Fungal keratitis (FK) is a severe ocular disease that may cause blindness in severe cases. The only FDA-approved first-lin...
A self-unfolding polymer foil loaded with a permeation enhancer Ionogel for superior oral peptide delivery
A self-unfolding polymer foil loaded with a permeation enhancer Ionogel for superior oral peptide delivery
Peptide drugs have gained considerable attention as new molecular entities, due to their high target specificity. However,...
Impact of high cyclodextrins concentrations on ocular safety and surface permanence
Impact of high cyclodextrins concentrations on ocular safety and surface permanence
Cyclodextrins (CDs) have been widely explored in ophthalmic formulations to enhance the bioavailability of poorly water-so...
Consistent aerodynamic performance and content uniformity of mometasone-magnesium stearate co-processed aerosols for asthma therapy
Consistent aerodynamic performance and content uniformity of mometasone-magnesium stearate co-processed aerosols for asthma therapy
Pressurized metered-dose inhalers (pMDIs) are a common technology for delivering respiratory medications, but the stabilit...
Harnessing synergistic SN38/quercetin nanomicelles via nebulized inhalation for enhanced lung cancer treatment
Harnessing synergistic SN38/quercetin nanomicelles via nebulized inhalation for enhanced lung cancer treatment
Lung cancer remains a leading cause of cancer-related mortality worldwide, while the clinical utility of irinotecan-derive...
Focused ultrasound-mediated opening of the blood brain barrier for non-invasive drug delivery to the murine cerebellum
Focused ultrasound-mediated opening of the blood brain barrier for non-invasive drug delivery to the murine cerebellum
The blood brain barrier (BBB) limits effective treatment for cerebellar diseases. Region-specific parameterization and saf...
Dissecting corneal drug permeability under experimental variability and drug cold-start challenges via hybrid machine learning
Dissecting corneal drug permeability under experimental variability and drug cold-start challenges via hybrid machine learning
Corneal drug permeability is a key determinant of topical ocular drug delivery efficiency, yet its quantitative prediction...
Multi-component microneedle drug delivery system of sanfu herbal patch for allergic asthma in rats
Multi-component microneedle drug delivery system of sanfu herbal patch for allergic asthma in rats
A dissolvable microneedle system (SFP-MNs) loaded with seven principal Sanfu Herbal Patch components was developed to asse...
Brain-targeted intranasal aripiprazole via modified chitosan nanoparticles: controlled release, pharmacokinetics, and pharmacodynamics
Brain-targeted intranasal aripiprazole via modified chitosan nanoparticles: controlled release, pharmacokinetics, and pharmacodynamics
Schizophrenia remains one of the most disabling mental disorders, and effective therapy is still limited by the difficulty...
Advances in stimuli-responsive hydrogels for liver disease therapy: mechanisms, applications, and translational perspectives
Advances in stimuli-responsive hydrogels for liver disease therapy: mechanisms, applications, and translational perspectives
The liver is a pivotal organ for metabolic and immune homeostasis, playing an essential role in maintaining physiological ...
Repositioning pentoxifylline via inhalable novasomes for pulmonary fibrosis: from statistical optimization to in-vivo evaluation
Repositioning pentoxifylline via inhalable novasomes for pulmonary fibrosis: from statistical optimization to in-vivo evaluation
Pulmonary fibrosis (PF) represents the final stage of lung injuries, triggered mainly by viral infections. Pentoxifylline ...
Endothelial progenitor cells-derived exosomes reduce ferroptosis and promote neovascularization after intracranial atherosclerosis in association with the NCOA4/FTH1 cascade modulation
Endothelial progenitor cells-derived exosomes reduce ferroptosis and promote neovascularization after intracranial atherosclerosis in association with the NCOA4/FTH1 cascade modulation
Intracranial atherosclerosis (ICAS) is a leading cause of ischemic stroke. This study explored the mechanism of endothelia...
Imaging of intranasal drug delivery to the brain: updated review 2.0
Imaging of intranasal drug delivery to the brain: updated review 2.0
Since the first review on imaging of intranasal drug delivery (INDD) was published in 2020, interest in the topic has incr...
Dissolving microneedle delivery of anemoside B4: a strategy to enhance therapeutic efficacy against psoriasis
Dissolving microneedle delivery of anemoside B4: a strategy to enhance therapeutic efficacy against psoriasis
Psoriasis, a chronic immune-mediated skin disease, lacks satisfactory treatment options due to the inherent limitations of...
Milk derived exosomes sensitize Gefitinib-resistant lung cancer cells to Pemetrexed via CAV1-mediated endocytosis
Milk derived exosomes sensitize Gefitinib-resistant lung cancer cells to Pemetrexed via CAV1-mediated endocytosis
Lung cancer patients resistant to EGFR-TKIs often demonstrate a decreased response to Pemetrexed. Therefore, it is urgent ...
Immunotherapeutic efficacy of transdermal delivery of anti-CD3 antibody-conjugated magnetic nanoparticles using a hyaluronic acid-based dissolving microneedle patch
Immunotherapeutic efficacy of transdermal delivery of anti-CD3 antibody-conjugated magnetic nanoparticles using a hyaluronic acid-based dissolving microneedle patch
Transdermal delivery of biologics remains challenging due to the stratum corneum barrier, which limits the clinical transl...
Biguanide‑modified ursolic acid as a multifunctional lipid‑mimetic carrier of DOX liposome for synergistic chemotherapy
Biguanide‑modified ursolic acid as a multifunctional lipid‑mimetic carrier of DOX liposome for synergistic chemotherapy
Doxorubicin (DOX) therapy is constrained by limited tumor accumulation, inefficient intracellular delivery, and dose-depen...
A microenvironment-responsive microsphere–PLGA-PEG-PLGA hydrogel for sustained and coordinated co-delivery of celecoxib and ropivacaine in osteoarthritis therapy
A microenvironment-responsive microsphere–PLGA-PEG-PLGA hydrogel for sustained and coordinated co-delivery of celecoxib and ropivacaine in osteoarthritis therapy
In this study, celecoxib (CXB) microspheres (CM) and ropivacaine (RPV) microspheres (RM) were prepared respectively. A pol...
In vivo spatiotemporal fate of nanoparticle-incorporated dissolving microneedles: nanoparticle size effects
In vivo spatiotemporal fate of nanoparticle-incorporated dissolving microneedles: nanoparticle size effects
Integrating dissolving microneedles (DMNs) with nanocarrier (NC) provides an effective strategy to overcome the stratum co...
Therapeutic approaches for targeting the pediatric brain tumor microenvironment
Therapeutic approaches for targeting the pediatric brain tumor microenvironment
Central nervous system (CNS) tumors are the most frequent solid malignant tumors in pediatric patients and are the leading...
Sex-specific formulations of doxazosin mesylate via direct powder extrusion 3D printing
Sex-specific formulations of doxazosin mesylate via direct powder extrusion 3D printing
Males and females are known to exhibit significant differences in drug pharmacokinetics and pharmacodynamics, which are st...
Development of silver-based hybrid nanoparticles loaded with eEF2 K-siRNA and quercetin against triple-negative breast cancer
Development of silver-based hybrid nanoparticles loaded with eEF2 K-siRNA and quercetin against triple-negative breast cancer
Breast cancer is the most common cancer among women, with approximately 2.3 million new cases globally. Triple-negative br...
Emerging nano-derived therapy for the treatment of dementia: a comprehensive review
Emerging nano-derived therapy for the treatment of dementia: a comprehensive review
Dementia includes a variety of neurodegenerative diseases that affect and target the brain’s fundamental cognitive f...
Oral peptide drug delivery: design of SEDDS providing a protective effect against intestinal membrane-bound enzymes
Oral peptide drug delivery: design of SEDDS providing a protective effect against intestinal membrane-bound enzymes
This study presents an emerging approach for oral peptide drug delivery by designing self-emulsifying drug delivery system...
Formulation and clinical translation of inhalable nanomedicines for the treatment and prevention of pulmonary infectious diseases
Formulation and clinical translation of inhalable nanomedicines for the treatment and prevention of pulmonary infectious diseases
Pulmonary infections caused by bacteria, viruses and fungi are a significant global health issue. Inhalation therapies are...
The translational journey of cancer nanomedicines: biological and entrepreneurial lessons learned
The translational journey of cancer nanomedicines: biological and entrepreneurial lessons learned
Despite exhaustive investments, the breakthrough potential of nanomedicines (NM) is not yet realized. Whilst Doxil and cov...
S.C. delivery of ultra-high concentration (up to 500 mg/mL) protein microparticle suspensions: pharmacokinetics, efficacy, biodistribution, and immunogenicity
S.C. delivery of ultra-high concentration (up to 500 mg/mL) protein microparticle suspensions: pharmacokinetics, efficacy, biodistribution, and immunogenicity
A shift towards the subcutaneous (S.C.) delivery of protein therapeutics is enabling patient-centric at-home self-administ...
Buccal application of microneedles coated with an optimized hydrogel containing naproxen and dexamethasone
Buccal application of microneedles coated with an optimized hydrogel containing naproxen and dexamethasone
Inflammation and impaired bone regeneration are major challenges in oral and maxillofacial surgery, necessitating the deve...
Post-encapsulation methods for the preparation of mRNA-LNPs
Post-encapsulation methods for the preparation of mRNA-LNPs
Microfluidics mixing is the current lab-scale method used for producing mRNA-loaded lipid nanoparticles (mRNA-LNPs) thanks...
Radiolabelling and bioequivalence of modified Tamoxifen solid lipid nanoparticles as a targeted chemotherapeutic drug
Radiolabelling and bioequivalence of modified Tamoxifen solid lipid nanoparticles as a targeted chemotherapeutic drug
There are several types of breast cancer where the breast's cells proliferate uncontrollably. A selective oestrogen re...
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