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The cancer survivorship paradox in the digital era
Many assumptions around patient needs and support guide current oncology practice and cancer survivorship care in the digi...
Expanding the Developmental Origins of Health and Disease beyond maternal behaviors
Developmental Origins of Health and Disease (DOHaD) research has long emphasized maternal pregnancy behaviors as key deter...
World Humanitarian Day: Why humanitarian settings need more research, not less
In this Editorial, Akihiro Seita outlines how and why medical journals should recognize that while conventional study desi...
Winners of Lasker Foundation Video Contest announced
Published in Volume 136, Issue 14 on July 15, 2026 J Clin Invest. 2026;136(14):e210286. https://doi.org/10.1172/JCI210...
Evolution of clonal hematopoiesis during cancer treatment and its impact on outcomes
Research ArticleClinical ResearchGeneticsOncology Open Access | 10.1172/JCI204429 Mona Arabza...
Single-cell analysis of fetal testis reveals dysfunction of human Leydig cells in Klinefelter syndrome
Research ArticleCell biologyReproductive biology Open Access | 10.1172/JCI201124 Tong Yan,1 ...
SIRT2-mediated deacetylation activates USP22 catalytic function for PD-L1 protein stabilization and tumor immune escape
Identification of SIRT2 as a positive regulator to control PD-L1 protein expression in cancer cells at the posttranscript...
CXCR6+ CD127– Tr1 cells balance immunity and persistence in Plasmodium falciparum infection
Research ArticleImmunologyInfectious disease Open Access | 10.1172/JCI200628 Jason Nideffer,1...
Aberrant STAT signaling and T cell dysregulation define a targetable pediatric sepsis endotype
Clinical Research and Public HealthClinical ResearchImmunologyInflammation Open Access | 10.1172/JCI202867 ...
Gut microbe–derived short-chain fatty acids regulate alphavirus arthritis and macrophage activation in mice
Research ArticleImmunologyInfectious diseaseMicrobiology Open Access | 10.1172/JCI202262 Fang...
Sterol biosynthesis, brain development, and disease
The work described here firmly establishes the critical requirement for cholesterol biosynthesis during brain development...
Pathological disruption of CELF2 shuttling causes neuronal hyperactivity, learning deficits, and seizures
Research ArticleClinical ResearchDevelopmentGenetics Open Access | 10.1172/JCI199698 Michelle...
Antigen-specific type 1 regulatory T cell responses shape immunity and disease tolerance in human malaria
In this issue, Nideffer et al. (15) define the functional role of human Tr1 cells during pediatric Plasmodium falciparum ...
TGF-β signaling promotes astroglial activation and TDP-43 proteinopathy in organoid models of frontotemporal lobar degeneration
Loss of PGRN leads to aberrant growth in cortical organoids. To determine how PGRN deficiency might impact neurodevelopme...
The bone-cerebrovascular axis: effects of bone aging on neurovascular dysfunction and neurodegeneration
Age-related changes in bone. The skeletal system is a dynamic structure that undergoes continuous remodeling (100), which...
Fumarate-induced succination of A-kinase anchor protein 12 exacerbates renal inflammation and fibrosis
Research ArticleInflammationMetabolismNephrology Open Access | 10.1172/JCI200755 Shuai Sun,1,...
Osteopontin mediates acquired resistance to hypoxia-inducing antiangiogenics and promotes anti–PD-L1 refractoriness in breast cancer models
Hypoxia-inducing antiangiogenic treatment upregulates the PD-1/PD-L1 axis, but blocking it in this context lacks efficacy...
Therapy-resistant lymphomas may want nucleotides, but they just need to grow
When Jagger and Richards wrote the lines “You can’t always get what you want, but if you try sometime…you get what you ne...
SLC15A3-mediated dipeptide metabolism confers antimetabolite resistance in lymphoma via mTORC1 activation
Research ArticleHematologyMetabolismOncology Open Access | 10.1172/JCI199709 Haojun Yang,1,2,...
SEC16B identified as a regulator of VLDL secretion and lipid accumulation in the liver
Lu and colleagues identified SEC16B as a regulator of both VLDL and LD metabolism (5). Previous GWAS identified an associ...
Hepatic SEC16B regulates lipid homeostasis by coordinating VLDL secretion and lipid droplet expansion
SNP in SEC16B is associated with plasma cholesterol levels in humans. GWAS has identified that 1 of the SNPs (rs6682862, ...
The perinecrotic niche of glioblastoma drives tumor-associated macrophage polarization and immunosuppression via podoplanin-mediated CLEC5A activation
CLEC5A expression by TAM-IM is a strong predictor of poor clinical outcomes. To characterize TME profiles of IDH-WT GBM a...
Hamburger, Franz (1874–1954)
Hamburger, Franz (1874–1954)
Franz Hamburger spezialisierte sich nach seinem Medizinstudium auf Pädiatrie. 1930 wurde er Vorstand der Wiener Kind...
History of the Rigid Bronchoscope
History of the Rigid Bronchoscope
Three inventions were the prerequisites for the development of bronchoscopy, which all came about in the second half of th...
Risak, Erwin (1899–1968)
Risak, Erwin (1899–1968)
Erwin Risak studierte Medizin in Wien und wurde illegales NSDAP- und SS-Mitglied. 1933 wurde er bei Eppinger habilitiert. ...
Beiglböck, Wilhelm (1905–1963)
Beiglböck, Wilhelm (1905–1963)
Wilhelm Beiglböck war Assistent von EppingerEppinger, der ihn mit den MeerwassertrinkversucheMeerwassertrinkversuchen...
Indications for Carotid Surgery
Indications for Carotid Surgery
More than 100 years of carotid artery surgery brought significant technical changes and even more relevant improvemen...
Eppinger, Hans (1879–1946)
Eppinger, Hans (1879–1946)
Hans Eppinger hatte bereits vor dem „Dritten Reich“ Lehrstühle an verschiedenen Universitäten innege...
Medizin im „Dritten Reich“
Medizin im „Dritten Reich“
Dieses Kapitel geht kurz auf die Umstände ein, die österreichische Mediziner nach dem Anschluss vorfanden. In kn...
The College of Physicians in Vienna and its Jewish members after Austria’s annexation () to Nazi Germany in 1938
The College of Physicians in Vienna and its Jewish members after Austria’s annexation () to Nazi Germany in 1938
This text outlines the process by which Jewish members of the College of Physicians in Vienna (Gesellschaft der Ärzte...
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