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An -deficient hypoperfusion model reveals Moyamoya-relevant neurovascular remodeling
An -deficient hypoperfusion model reveals Moyamoya-relevant neurovascular remodeling
Moyamoya disease (MMD) is a chronic cerebrovascular disorder characterized by progressive stenosis of the terminal portion...
Characterizing pancreatic cancer-associated fibroblast heterogeneity in vascular microphysiological systems
Characterizing pancreatic cancer-associated fibroblast heterogeneity in vascular microphysiological systems
Pancreatic Ductal Adenocarcinoma (PDAC), one of the deadliest cancer types, is dominated by a tumor microenvironment (TME)...
Prevascularized grafts with spatially organized MSC spheroids to accelerate therapeutic angiogenesis in ischemic disease
Prevascularized grafts with spatially organized MSC spheroids to accelerate therapeutic angiogenesis in ischemic disease
Ischemic diseases, characterized by impaired blood flow and progressive tissue necrosis, remain a major challenge in regen...
Endothelial AGO1 deficiency reduces breast cancer burden in mice
Endothelial AGO1 deficiency reduces breast cancer burden in mice
Endothelial cells (ECs) are crucial in cancer development and progression, partly by regulating tumor angiogenesis and imm...
MCC links Wnt/PCP signaling to endothelial polarity and vascular remodeling
MCC links Wnt/PCP signaling to endothelial polarity and vascular remodeling
Vascular remodeling is crucial for establishing a functional vasculature and maintaining organ homeostasis. In the central...
controls developmental angiogenesis via ribosome biogenesis-dependent regulation of Notch signaling
controls developmental angiogenesis via ribosome biogenesis-dependent regulation of Notch signaling
The development of a functional vasculature is controlled by the coordination of various mechanisms. Key molecules and sig...
A possible microvascular vulnerability in carotid artery dissection: insights from nailfold capillaroscopy
A possible microvascular vulnerability in carotid artery dissection: insights from nailfold capillaroscopy
Competing interests The authors declare no competing intere...
Tumour endothelial cell reprogramming orchestrates angiocrine signalling to drive chemoresistance in breast cancer
Tumour endothelial cell reprogramming orchestrates angiocrine signalling to drive chemoresistance in breast cancer
Despite its established role in breast cancer treatment, Doxorubicin treatment remains subject to adaptive resistance mech...
Endothelial Notch1 drives multicellular remodelling during hyaloid vessel regression
Endothelial Notch1 drives multicellular remodelling during hyaloid vessel regression
Hyaloid vessel regression is essential for vitreous transparency and normal vision, yet how this transient vascular networ...
Endothelial VEGFR2 insufficiency promotes the transition of lymphatic to hematopoietic transcriptional programs
Endothelial VEGFR2 insufficiency promotes the transition of lymphatic to hematopoietic transcriptional programs
Vascular endothelial growth factor receptor-2 (VEGFR2) is a key target for regulating the endothelial cell lineage and ang...
Semi-automated quantification of total and avascular retinal area in the rat model of oxygen-induced retinopathy
Semi-automated quantification of total and avascular retinal area in the rat model of oxygen-induced retinopathy
Quantification of retinal and avascular areas in the rat oxygen induced retinopathy (OIR) model is traditionally performed...
Critical role of endothelial regulator of G protein signaling 5 in postnatal angiogenesis
Critical role of endothelial regulator of G protein signaling 5 in postnatal angiogenesis
Regulator of G protein signaling 5 (RGS5) modulates G-protein coupled receptor (GPCR) signaling and is markedly upregulate...
Functional definition of endothelial progenitors by PROCR and PDGFRA co-expression
Functional definition of endothelial progenitors by PROCR and PDGFRA co-expression
The functional and molecular definition of progenitors giving rise to blood vessel endothelium in vivo remains disputed. U...
3D co-culture model of tumor spheroid and endothelial cells unveils ccRCC aberrant vasculature and distinct sensitivity to targeted treatments
3D co-culture model of tumor spheroid and endothelial cells unveils ccRCC aberrant vasculature and distinct sensitivity to targeted treatments
Clear cell renal cell carcinoma (ccRCC), the most common renal cancer, is largely driven by von Hippel Lindau (VHL) protei...
Long-term angiogenic and thromboinflammatory signatures in post-COVID-19 syndrome
Long-term angiogenic and thromboinflammatory signatures in post-COVID-19 syndrome
Post-COVID-19 syndrome is a major long-term sequela of severe SARS-CoV-2 infection, potentially involving persistent angio...
Smad3 deficiency attenuates disease severity in a zebrafish model for Smad6-related aortic disease
Smad3 deficiency attenuates disease severity in a zebrafish model for Smad6-related aortic disease
Thoracic aortic dissection (TAD) associates with a high mortality rate. Treatment options are limited and mainly consist o...
Lysosomal channel TPC2 modulates microglia-endothelial signaling in choroidal angiogenesis
Lysosomal channel TPC2 modulates microglia-endothelial signaling in choroidal angiogenesis
Pathological choroidal neovascularization underlies vision loss in neovascular age-related macular degeneration (nAMD), ye...
A high-sensitivity TIE2–GRB2 BRET platform for functional and pharmacologic profiling of pathogenic variants associated with venous malformations
A high-sensitivity TIE2–GRB2 BRET platform for functional and pharmacologic profiling of pathogenic variants associated with venous malformations
TIE2 is an endothelial receptor tyrosine kinase (RTK) essential for vascular integrity, and constitutively active TIE2 mut...
Passive smoking and hypertensive disorders of pregnancy
Akiyama M, Michikawa T, Takeda Y, Asakura K, Imamura H, Sugimoto M, et al. Partner’s dual use of new tobacco products and ...
Author's reply to the letter regarding “Passive smoking and hypertensive disorders of pregnancy”
We appreciate the thoughtful letter from Dr. Ghanouni and colleagues regarding our recent article [1, 2]. Their comments h...
Zinc-containing polaprezinc as an adjunctive strategy for salt reduction in older hypertensive adults: Clinical perspectives from community-based practice in Japan
Zinc-containing polaprezinc as an adjunctive strategy for salt reduction in older hypertensive adults: Clinical perspectives from community-based practice in Japan
Along with age-related physiological decline, zinc deficiency and polypharmacy often exacerbate impaired taste perception,...
Automated optical coherence tomography quantification of retinal wall-to-lumen alterations in preeclampsia
Automated optical coherence tomography quantification of retinal wall-to-lumen alterations in preeclampsia
Preeclampsia is associated with systemic endothelial dysfunction and microvascular injury, but direct noninvasive evidence...
High incidence of colorectal cancer in Japanese individuals with hypertension
High incidence of colorectal cancer in Japanese individuals with hypertension
The association between hypertension and the incidence of colorectal cancer remains controversial. This study aimed to cla...
First-harmonic attenuation of radial pulse waves as a sensitive marker for vascular aging
First-harmonic attenuation of radial pulse waves as a sensitive marker for vascular aging
Accurate assessment of vascular aging and arterial stiffness is essential for early cardiovascular intervention. Tradition...
Response to: Comment on: The renin-angiotensin system in models of pulmonary arterial hypertension vs primary hypertension
We would like to express our sincere gratitude for the constructive comments by Dr. Balkar to our mini-review [1]. We beli...
Comment on: Association between blood pressure and risk of ischemic stroke among individuals with dementia: A nationwide cohort study
Comment on: Association between blood pressure and risk of ischemic stroke among individuals with dementia: A nationwide cohort study
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
Nocturnal blood pressure and the risk of preeclampsia: an overlooked link
Nocturnal blood pressure and the risk of preeclampsia: an overlooked link
Redman CW, Beilin LJ, Bonnar J. Reversed diurnal blood pressure rhythm in hypertensive pregnancies. Clin Sci Mol Med Suppl...
Sleep quality, isolated nocturnal hypertension, and cardiovascular risk: clarifying a complex relationship
Amin KD, Thakkar A, Budampati T, Matai S, Akkaya E, Shah NP, et al. A good night’s rest: A contemporary review of sleep an...
Masked hypertension and non-dipping blood pressure profiles in pediatric survivors of acute kidney injury: a systematic review and meta-analysis
Masked hypertension and non-dipping blood pressure profiles in pediatric survivors of acute kidney injury: a systematic review and meta-analysis
Pediatric acute kidney injury (AKI) is increasingly recognized as a condition with long-term chronic consequences, rather ...
Prevalence and trends of hypertension among South Asian adults: a systematic review and meta-analysis
Prevalence and trends of hypertension among South Asian adults: a systematic review and meta-analysis
Hypertension, a major contributor to global cardiovascular disease related deaths, has seen a rise in low- and middle-inco...
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