SCI Abstract

search
+
Integrative multi-omics identifies CYP1B1 as a candidate molecular link between toxicant exposure and ferroptosis-related epithelial stress in COPD
Integrative multi-omics identifies CYP1B1 as a candidate molecular link between toxicant exposure and ferroptosis-related epithelial stress in COPD
Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation, chronic airway inflammati...
From copper imbalance to immunometabolic remodeling: cuproptosis-related vulnerability and therapeutic hypotheses in autoimmune diseases
From copper imbalance to immunometabolic remodeling: cuproptosis-related vulnerability and therapeutic hypotheses in autoimmune diseases
Autoimmune diseases (AIDs) are characterized by disrupted immune tolerance, chronic inflammation, and organ-specific tissu...
Niflumic acid suppresses NLRP3 inflammasome activation by limiting chloride efflux and mitochondrial ROS production
Niflumic acid suppresses NLRP3 inflammasome activation by limiting chloride efflux and mitochondrial ROS production
Aberrant activation of the NLRP3 inflammasome contributes to the development of multiple inflammatory disorders, but clini...
Myeloid PKM2 deficiency alleviates allergic airway inflammation and promotes macrophage efferocytosis via SLC13A3
Myeloid PKM2 deficiency alleviates allergic airway inflammation and promotes macrophage efferocytosis via SLC13A3
Allergic asthma is characterized by chronic airway inflammation that fails to resolve efficiently. Defective efferocytosis...
Lipopolysaccharide-mediated macrophage polarization, conserved pathogenesis, and implications for peripheral neuropathy: a systematic review
Lipopolysaccharide-mediated macrophage polarization, conserved pathogenesis, and implications for peripheral neuropathy: a systematic review
This systematic review synthesized evidence for a conserved lipopolysaccharide (LPS)-mediated pathogenic mechanism across ...
Autosomal recessive A20 zinc finger 7 mutation is associated with early-onset lupus-like disease
Autosomal recessive A20 zinc finger 7 mutation is associated with early-onset lupus-like disease
A20 is an anti-inflammatory protein that suppresses nuclear factor-κB (NF-κB)-mediated inflammatory gene express...
SERPINE1 in ARDS: an emerging regulator of inflammation–coagulation–fibrinolysis crosstalk
SERPINE1 in ARDS: an emerging regulator of inflammation–coagulation–fibrinolysis crosstalk
This narrative review synthesizes current evidence on the role of SERPINE1/PAI-1 in acute respiratory distress syndrome (A...
NKRCD8 T cells and iNKT cells protect mice from AOM/DSS-induced colorectal cancer under conditions of IFNγ-mediated hyperinflammation
NKRCD8 T cells and iNKT cells protect mice from AOM/DSS-induced colorectal cancer under conditions of IFNγ-mediated hyperinflammation
Interferon-gamma (IFNγ) is a pivotal cytokine in immune surveillance and inflammation, yet its precise role in colore...
Effect of gut bacterial extracellular vesicles on angiogenic potential and vascular integrity: positive and negative aspects
Effect of gut bacterial extracellular vesicles on angiogenic potential and vascular integrity: positive and negative aspects
Extracellular vesicles (EVs) are intercellular mediators in prokaryotic and eukaryotic systems that have the potential to ...
Regulation of Tph cell differentiation via farnesoid X receptor of dendritic cells in inflammatory bowel disease
Regulation of Tph cell differentiation via farnesoid X receptor of dendritic cells in inflammatory bowel disease
Peripheral helper T cells represent a recently characterized subset of CD4+ T cells present in inflammatory bowel disease ...
International comparison of neutrophil surface markers after severe trauma is feasible using point of care flowcytometry - results from a pilot study
International comparison of neutrophil surface markers after severe trauma is feasible using point of care flowcytometry - results from a pilot study
The dynamics of cell surface marker expression on systemic neutrophils provide valuable insights into the post-traumatic i...
MICA gene modulates immune microenvironment and comorbid mechanisms in diffuse large B-cell lymphoma and primary Sjögren’s syndrome
MICA gene modulates immune microenvironment and comorbid mechanisms in diffuse large B-cell lymphoma and primary Sjögren’s syndrome
To identify shared molecular mechanisms and crosstalk genes (CGs) between diffuse large B-cell lymphoma (DLBCL) and primar...
TRPV4/IP3R-1-mediated endothelial pyroptosis drives pulmonary microvascular endothelial permeability in endotoxin-induced acute lung injury
TRPV4/IP3R-1-mediated endothelial pyroptosis drives pulmonary microvascular endothelial permeability in endotoxin-induced acute lung injury
Sepsis-induced acute lung injury (ALI) is characterized by edema resulting from increased vascular permeability. Transient...
Context-dependent lysophosphatidic acid signalling in inflammation: evidence hierarchy, myeloid regulation and translational gaps
Context-dependent lysophosphatidic acid signalling in inflammation: evidence hierarchy, myeloid regulation and translational gaps
Lysophosphatidic acid (LPA) has been extensively reviewed in receptor pharmacology, fibrosis, cancer, vascular biology and...
infection reduces CD59 expression through downregulation of JAK2/STAT3 signaling axis to enhance decidual NK cell cytotoxicity via the RAS/MAPK pathway
infection reduces CD59 expression through downregulation of JAK2/STAT3 signaling axis to enhance decidual NK cell cytotoxicity via the RAS/MAPK pathway
Toxoplasma gondii (T. gondii) infection disrupts pregnancy by modulating decidual natural killer (dNK) cells function. Thi...
LncRNA SNHG14 drives alveolar inflammation in bronchopulmonary dysplasia via DNMT3a-mediated epigenetic silencing of miR-214-3p
LncRNA SNHG14 drives alveolar inflammation in bronchopulmonary dysplasia via DNMT3a-mediated epigenetic silencing of miR-214-3p
This experimental study investigated whether lncRNA SNHG14 contributes to hyperoxia-associated bronchopulmonary dysplasia ...
GPR132 antagonists alleviate atherosclerosis by suppressing M1 polarization and subsequent VSMCs proliferation and migration as revealed by transcriptomic profiling
GPR132 antagonists alleviate atherosclerosis by suppressing M1 polarization and subsequent VSMCs proliferation and migration as revealed by transcriptomic profiling
Atherosclerosis (AS) is a chronic inflammatory disorder with substantial global prevalence, wherein macrophage polarizatio...
Immunometabolic regulation and tissue-resident immunity in autoimmune uveitis: from genetic susceptibility to the gut-spleen-eye axis
Immunometabolic regulation and tissue-resident immunity in autoimmune uveitis: from genetic susceptibility to the gut-spleen-eye axis
This narrative review synthesizes current evidence on the immunopathogenesis of autoimmune uveitis(AU), with particular em...
Distinct miRNA expression patterns in circulating eosinophil subtypes and their subtype-derived exosomes in allergic asthma
Distinct miRNA expression patterns in circulating eosinophil subtypes and their subtype-derived exosomes in allergic asthma
Lung-resident (rEos) and inflammatory (iEos) eosinophil subtypes were initially characterized in mouse models of asthma an...
Cellular crosstalk between endothelial and vascular smooth muscle cells via the BACH1/COL3A1 axis promotes vascular calcification in chronic kidney disease
Cellular crosstalk between endothelial and vascular smooth muscle cells via the BACH1/COL3A1 axis promotes vascular calcification in chronic kidney disease
High phosphate levels lead to significant pathological changes in vascular smooth muscle cells (VSMCs) and endothelial cel...
Protein function evolution through the lens of conformational dynamics: A single-molecule perspective
All content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
Recent advances on structure and dynamics of G protein–coupled receptors using single-molecule Förster resonance energy transfer
All content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
Progress in structure prediction and design of adaptive immune receptors
All content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
Structural dissection of apicomplexan gliding motility
All content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
Computational modeling of regulated protein conformational transitions
All content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
Mapping the relationship between receptor dynamics and function in G protein–coupled receptors using molecular dynamics
All content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
Detergent-free extraction polymers in membrane protein structure determination
All content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
Tomogram exploration through template matching and deep learning
All content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
A comparative review of cryo-electron ptychography: Biological applications and future perspectives
All content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
Transforming cryo-lift-out one section at a time
All content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, includ...
Load More
format_indent_increase