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Protein function evolution through the lens of conformational dynamics: A single-molecule perspective

Recent advances on structure and dynamics of G protein–coupled receptors using single-molecule Förster resonance energy transfer

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Progress in structure prediction and design of adaptive immune receptors

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Structural dissection of apicomplexan gliding motility

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Computational modeling of regulated protein conformational transitions

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Mapping the relationship between receptor dynamics and function in G protein–coupled receptors using molecular dynamics

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Detergent-free extraction polymers in membrane protein structure determination

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Tomogram exploration through template matching and deep learning

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A comparative review of cryo-electron ptychography: Biological applications and future perspectives

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Transforming cryo-lift-out one section at a time

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Current challenges in cryogenic super-resolution fluorescence microscopy in the context of cryogenic electron microscopy/tomography

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Machine learning and language models for RNA structure prediction: Progress and perspectives

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How crowding shapes protein aggregation

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Crowding at the cellular membranes: Emerging physiological roles and novel study approaches

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Physicochemical principles of RNA-mediated crowding

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Intracellular biomolecular condensates viewed by Raman microscopy: Composition, crowding, and hydration

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Progress toward linking single-molecule behavior and condensate material properties

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Nuclear magnetic resonance spectroscopy as a tool to probe molecular condensates

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Databases of liquid–liquid phase separation proteins and condensates

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Multimodal biophysical markers of neurodegeneration: Morphology, mechanics, and thermodynamics

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Editorial overview: Artificial intelligence methodologies in structural biology

Pratyush Tiwary is a Professor at the University of Maryland, College Park, where he holds the Millard and Lee Alexander P...

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Membrane protein reconstitution : New possibilities for structural biology, biophysical methods, and antibody/drug discovery

Liguo Wang is the Director of Scientific Operations at the Laboratory for BioMolecular Structure at Brookhaven National La...

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Dynamic characteristics of proteolysis-targeting chimera systems revealed by in silico computations

Proteolysis-targeting chimera (PROTAC), as a paradigm of proximity-inducing compounds, uses a unique bifunctional small-mo...

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Computational modeling of protein–ligand interactions: From binding site identification to pose prediction and beyond

Protein-ligand modeling is a cornerstone of modern drug discovery, facilitating the identification and optimization of bio...

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Resistance mutations, drug binding and drug residence times

The rapid evolution of microorganisms and cancer cells makes it difficult to treat tumours and infectious diseases, becaus...

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Recent advances in DNA-encoded libraries: From covalent targeting to protein profiling

DNA-encoded libraries (DELs) are constructed using split-and-pool strategies that enable the systematic assembly of divers...

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Allosteric solution to the problems of undruggable targets, drug toxicity, and emerging resistance

Volume 95, December 2025, 103172Author links open overlay panel, Though allostery is a well-established research field, it...

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Chromatin higher-order folding as influenced by preferred values of linker DNA

Specific values of nucleosome spacing have long been associated with distinct chromatin organization, but recent studies r...

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Navigating protein–nucleic acid sequence-structure landscapes with deep learning

A few years after AlphaFold revolutionised the field of protein structure prediction, the new frontiers and limitations in...

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Understanding how structure shapes the architecture of homologous recombination

HRHomologous RecombinationROSReactive Oxygen SpeciesNHEJNon-homologous end joiningSSAsingle-strand annealingBIRbreak-induc...

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