Understanding how structure shapes the architecture of homologous recombination

HR

Homologous Recombination

ROS

Reactive Oxygen Species

NHEJ

Non-homologous end joining

SSA

single-strand annealing

BIR

break-induced replication

MMEJ

microhomology-mediated end joining

BRCA1

Breast cancer type 1 susceptibility protein

BRCA2

Breast Cancer gene 2

PALB2

Partner and localizer of BRCA2

53BP1

P53-binding protein 1

CDK

Cell cycle dependent kinases

CTIP

C–terminal binding protein

SAXS

Small Angle X-Ray Scattering

SASBDB

Small angle scattering biological databank

BARD1

BRCA1-associated RING domain protein 1

IDRs

intrinsically disordered regions

SMARCAD1

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

MRE11

double-strand break repair protein MRE11

RAD50

DNA repair protein RAD50

NBS1

Nijmegen breakage syndrome 1

DNA2

DNA replication ATP-dependent helicase/nuclease DNA2

BLM

Bloom syndrome helicase

MEIOB

Meiosis-specific with OB domain-containing protein

SPATA22

Spermatogenesis-associated protein 22

DSS1

26Sproteasome complex subunit 1

RMI1

RecQ Mediated Genome Instability 1

RMI2

RecQ Mediated Genome Instability 2

dHJs

double Holliday junctions

GEN1

Flap endonuclease GEN homolog 1

Cryo-EM

Cryogenic electron microscopy

RAD51

DNA repair protein RAD51 homolog 1

DMC1

Meiotic recombination protein DMC1 Meiotic recombination protein DMC1/LIM15 homolog

HED1

Meiosis-specific protein HED1

RAD52

DNA repair protein RAD52 homolog

PCNA

Proliferating cell nuclear antigen

RFC

Replication factor C subunit

PARP

Poly [ADP-ribose] polymerase

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