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Do we still need animals? Surveying the role of animal‐free models in Alzheimer’s and Parkinson’s disease research
Do we still need animals? Surveying the role of animal‐free models in Alzheimer’s and Parkinson’s disease research
The use of animals in neuroscience and biomedical research remains controversial. Policy is built around the “3R&#x...
What (H)IF isoform matters? A deubiquitinase can tune the hypoxic response
What (H)IF isoform matters? A deubiquitinase can tune the hypoxic response
Context-specific control mechanisms of hypoxia-inducible transcription factors HIF-1alpha and HIF-2alpha in tumors exposed...
Epigenetic inheritance is gated by naïve pluripotency and Dppa2
Epigenetic inheritance is gated by naïve pluripotency and Dppa2
Abstract Environmental factors can trigger cellular responses that propagate across mitosis or even generations. Perturbat...
AKT2 reduces IFNβ1 production to modulate antiviral responses and systemic lupus erythematosus
AKT2 reduces IFNβ1 production to modulate antiviral responses and systemic lupus erythematosus
Abstract Interferon regulatory factor 3 (IRF3)-induced type I interferon (I-IFN) production plays key roles in both antivi...
USP33 deubiquitinates and stabilizes HIF‐2alpha to promote hypoxia response in glioma stem cells
USP33 deubiquitinates and stabilizes HIF‐2alpha to promote hypoxia response in glioma stem cells
Abstract Hypoxia regulates tumor angiogenesis, metabolism, and therapeutic response in malignant cancers including gliobla...
Rewiring phospholipid biosynthesis reveals resilience to membrane perturbations and uncovers regulators of lipid homeostasis
Rewiring phospholipid biosynthesis reveals resilience to membrane perturbations and uncovers regulators of lipid homeostasis
Abstract The organelles of eukaryotic cells differ in their membrane lipid composition. This heterogeneity is achieved by ...
Specialization of actin isoforms derived from the loss of key interactions with regulatory factors
Specialization of actin isoforms derived from the loss of key interactions with regulatory factors
Abstract A paradox of eukaryotic cells is that while some species assemble a complex actin cytoskeleton from a single orth...
TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS‐CoV‐2 infection
TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS‐CoV‐2 infection
Abstract Understanding the molecular pathways driving the acute antiviral and inflammatory response to SARS-CoV-2 infectio...
Order through destruction: how ER‐associated protein degradation contributes to organelle homeostasis
Order through destruction: how ER‐associated protein degradation contributes to organelle homeostasis
Abstract The endoplasmic reticulum (ER) is a large, dynamic, and multifunctional organelle. ER protein homeostasis is esse...
Myc suppresses male–male courtship in Drosophila
Myc suppresses male–male courtship in Drosophila
Abstract Despite strong natural selection on species, same-sex sexual attraction is widespread across animals, yet the und...
PABP prevents the untimely decay of select mRNA populations in human cells
PABP prevents the untimely decay of select mRNA populations in human cells
Abstract Gene expression is tightly regulated at the levels of both mRNA translation and stability. The poly(A)-binding pr...
Cells on lockdown: long‐term consequences of CDK4/6 inhibition
Cells on lockdown: long‐term consequences of CDK4/6 inhibition
Inhibition of cyclin-dependent kinases Cdk4/6 is emerging as a useful anti-proliferative chemotherapy, but it remains uncl...
The PAX5‐JAK2 translocation acts as dual‐hit mutation that promotes aggressive B‐cell leukemia via nuclear STAT5 activation
The PAX5‐JAK2 translocation acts as dual‐hit mutation that promotes aggressive B‐cell leukemia via nuclear STAT5 activation
Abstract While PAX5 is an important tumor suppressor gene in B-cell acute lymphoblastic leukemia (B-ALL), it is also invol...
RNA sensing via the RIG‐I‐like receptor LGP2 is essential for the induction of a type I IFN response in ADAR1 deficiency
RNA sensing via the RIG‐I‐like receptor LGP2 is essential for the induction of a type I IFN response in ADAR1 deficiency
Abstract RNA editing by the adenosine deaminase ADAR1 prevents innate immune responses to endogenous RNAs. In ADAR1-defici...
Plant immunity suppression via PHR1‐RALF‐FERONIA shapes the root microbiome to alleviate phosphate starvation
Plant immunity suppression via PHR1‐RALF‐FERONIA shapes the root microbiome to alleviate phosphate starvation
Abstract The microbiome plays an important role in shaping plant growth and immunity, but few plant genes and pathways imp...
Spatial and temporal control of mitochondrial H2O2 release in intact human cells
Spatial and temporal control of mitochondrial H2O2 release in intact human cells
Abstract Hydrogen peroxide (H2O2) has key signaling roles at physiological levels, while causing molecular damage at eleva...
Telomeric C‐circles localize at nuclear pore complexes in Saccharomyces cerevisiae
Telomeric C‐circles localize at nuclear pore complexes in Saccharomyces cerevisiae
Abstract As in human cells, yeast telomeres can be maintained in cells lacking telomerase activity by recombination-based ...
Fluidity is the way to life: lipid phase separation in bacterial membranes
Fluidity is the way to life: lipid phase separation in bacterial membranes
A hallmark of biological membranes is the dynamic localization of lipids and proteins. Lipids respond to temperature reduc...
A neuropathy‐associated kinesin KIF1A mutation hyper‐stabilizes the motor‐neck interaction during the ATPase cycle
A neuropathy‐associated kinesin KIF1A mutation hyper‐stabilizes the motor‐neck interaction during the ATPase cycle
Abstract The mechanochemical coupling of ATPase hydrolysis and conformational dynamics in kinesin motors facilitates intra...
Single‐cell transcriptomics uncovers an instructive T‐cell receptor role in adult γδ T‐cell lineage commitment
Single‐cell transcriptomics uncovers an instructive T‐cell receptor role in adult γδ T‐cell lineage commitment
Abstract After entering the adult thymus, bipotent T-cell progenitors give rise to αβ or γδ T cell...
Neutrophils discriminate live from dead bacteria by integrating signals initiated by Fprs and TLRs
Neutrophils discriminate live from dead bacteria by integrating signals initiated by Fprs and TLRs
Abstract The mechanisms whereby neutrophils respond differentially to live and dead organisms are unknown. We show here th...
Disease‐linked TDP‐43 hyperphosphorylation suppresses TDP‐43 condensation and aggregation
Disease‐linked TDP‐43 hyperphosphorylation suppresses TDP‐43 condensation and aggregation
Abstract Post-translational modifications (PTMs) have emerged as key modulators of protein phase separation and have been ...
On the role of phase separation in the biogenesis of membraneless compartments
On the role of phase separation in the biogenesis of membraneless compartments
Molecular mechanistic biology has ushered us into the world of life’s building blocks, revealing their interactions...
Spt5 histone binding activity preserves chromatin during transcription by RNA polymerase II
Spt5 histone binding activity preserves chromatin during transcription by RNA polymerase II
Abstract Nucleosomes are disrupted transiently during eukaryotic transcription, yet the displaced histones must be retaine...
LAMTOR1 inhibition of TRPML1‐dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function
LAMTOR1 inhibition of TRPML1‐dependent lysosomal calcium release regulates dendritic lysosome trafficking and hippocampal neuronal function
Abstract Lysosomes function not only as degradatory compartments but also as dynamic intracellular calcium ion stores. The...
Teneurin4 dimer structures reveal a calcium‐stabilized compact conformation supporting homomeric trans‐interactions
Teneurin4 dimer structures reveal a calcium‐stabilized compact conformation supporting homomeric trans‐interactions
Abstract Establishment of correct synaptic connections is a crucial step during neural circuitry formation. The Teneurin f...
Ribosome slowdown triggers codon‐mediated mRNA decay independently of ribosome quality control
Ribosome slowdown triggers codon‐mediated mRNA decay independently of ribosome quality control
Abstract The control of mRNA stability plays a central role in regulating gene expression patterns. Recent studies have re...
Low membrane fluidity triggers lipid phase separation and protein segregation in living bacteria
Low membrane fluidity triggers lipid phase separation and protein segregation in living bacteria
Abstract All living organisms adapt their membrane lipid composition in response to changes in their environment or diet. ...
CDK4/6 inhibitors induce replication stress to cause long‐term cell cycle withdrawal
CDK4/6 inhibitors induce replication stress to cause long‐term cell cycle withdrawal
Abstract CDK4/6 inhibitors arrest the cell cycle in G1-phase. They are approved to treat breast cancer and are also underg...
Metabolic remodeling maintains a reducing environment for rapid activation of the yeast DNA replication checkpoint
Metabolic remodeling maintains a reducing environment for rapid activation of the yeast DNA replication checkpoint
Abstract Nucleotide metabolism fuels normal DNA replication and is also primarily targeted by the DNA replication checkpoi...
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