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Cancer-Associated Fibroblast Subpopulations With Diverse and Dynamic Roles in the Tumor Microenvironment
Cancer-Associated Fibroblast Subpopulations With Diverse and Dynamic Roles in the Tumor Microenvironment
Transcriptomic analyses decipher the CAF compartment in the TMEHistorically, IHC was the mainstay of CAF functional analys...
PERK, Beyond an Unfolded Protein Response Sensor in Estrogen-Induced Apoptosis in Endocrine-Resistant Breast Cancer
PERK, Beyond an Unfolded Protein Response Sensor in Estrogen-Induced Apoptosis in Endocrine-Resistant Breast Cancer
AbstractThe discovery of 17β-estradiol (E2)–induced apoptosis has clinical relevance. Mechanistically, E2 over activates n...
Building Tools for Machine Learning and Artificial Intelligence in Cancer Research: Best Practices and a Case Study with the PathML Toolkit for Computational Pathology
Building Tools for Machine Learning and Artificial Intelligence in Cancer Research: Best Practices and a Case Study with the PathML Toolkit for Computational Pathology
AbstractImaging datasets in cancer research are growing exponentially in both quantity and information density. These mass...
Clinical and Functional Significance of TP53 Exon 4-Intron 4 Splice Junction Variants
Clinical and Functional Significance of TP53 Exon 4-Intron 4 Splice Junction Variants
Clinical and Functional Significance of TP53 Exon 4–Intron 4 Splice Junction Variants Emilia M. ...
SGK2, 14-3-3, and HUWE1 Cooperate to Control the Localization, Stability, and Function of the Oncoprotein PTOV1
SGK2, 14-3-3, and HUWE1 Cooperate to Control the Localization, Stability, and Function of the Oncoprotein PTOV1
SGK2, 14-3-3, and HUWE1 Cooperate to Control the Localization, Stability, and Function of the Oncoprote...
Epigenetic Silencing of BMP6 by the SIN3A-HDAC1/2 Repressor Complex Drives Melanoma Metastasis via FAM83G/PAWS1
Epigenetic Silencing of BMP6 by the SIN3A-HDAC1/2 Repressor Complex Drives Melanoma Metastasis via FAM83G/PAWS1
Epigenetic Silencing of BMP6 by the SIN3A–HDAC1/2 Repressor Complex Drives Melanoma Metastasis via FAM8...
The E3 Ligase MIB1 Promotes Proteasomal Degradation of NRF2 and Sensitizes Lung Cancer Cells to Ferroptosis
The E3 Ligase MIB1 Promotes Proteasomal Degradation of NRF2 and Sensitizes Lung Cancer Cells to Ferroptosis
2CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, G...
A Functional Precision Oncology Approach to Identify Treatment Strategies for Myxofibrosarcoma Patients
A Functional Precision Oncology Approach to Identify Treatment Strategies for Myxofibrosarcoma Patients
AbstractIn this era of precision medicine, numerous workflows for the targeting of high-recurrent mutations in common tumo...
Enhanced Vulnerability of LKB1-Deficient NSCLC to Disruption of ATP Pools and Redox Homeostasis by 8-Cl-Ado
Enhanced Vulnerability of LKB1-Deficient NSCLC to Disruption of ATP Pools and Redox Homeostasis by 8-Cl-Ado
Enhanced Vulnerability of LKB1-Deficient NSCLC to Disruption of ATP Pools and Redox Homeostasis by 8-Cl...
GAS6/AXL Inhibition Enhances Ovarian Cancer Sensitivity to Chemotherapy and PARP Inhibition through Increased DNA Damage and Enhanced Replication Stress
GAS6/AXL Inhibition Enhances Ovarian Cancer Sensitivity to Chemotherapy and PARP Inhibition through Increased DNA Damage and Enhanced Replication Stress
GAS6/AXL Inhibition Enhances Ovarian Cancer Sensitivity to Chemotherapy and PARP Inhibition through Inc...
Ecdysoneless Protein Regulates Viral and Cellular mRNA Splicing to Promote Cervical Oncogenesis
Ecdysoneless Protein Regulates Viral and Cellular mRNA Splicing to Promote Cervical Oncogenesis
AbstractHigh-risk human papillomaviruses (HPV), exemplified by HPV16/18, are causally linked to human cancers of the anoge...
GATM-Mediated Creatine Biosynthesis Enables Maintenance of FLT3-ITD-Mutant Acute Myeloid Leukemia
GATM-Mediated Creatine Biosynthesis Enables Maintenance of FLT3-ITD-Mutant Acute Myeloid Leukemia
FMS-like tyrosine kinase 3 (FLT3) is one of the most frequently mutated genes in acute myeloid leukemia (AML), with the mo...
Glioblastoma-Astrocyte Connexin 43 Gap Junctions Promote Tumor Invasion
Glioblastoma-Astrocyte Connexin 43 Gap Junctions Promote Tumor Invasion
Glioblastoma multiforme (GBM), classified as World Health Organization grade IV astrocytoma, is the deadliest adult cancer...
Expression of Concern: Histone Demethylase JMJD1A Promotes Tumor Progression Via Activating Snail in Prostate Cancer
Expression of Concern: Histone Demethylase JMJD1A Promotes Tumor Progression Via Activating Snail in Prostate Cancer
The editors are publishing this note to alert readers to concerns about this article (1).Internal review detected 11 insta...
Oncogenic Activity of Glucocorticoid Receptor {beta} Is Controlled by Ubiquitination-Dependent Interaction with USP49 in Glioblastoma Cells
Oncogenic Activity of Glucocorticoid Receptor {beta} Is Controlled by Ubiquitination-Dependent Interaction with USP49 in Glioblastoma Cells
AbstractPrevious studies have demonstrated that glucocorticoid receptor β (GRβ) functions as an oncoprotein, regulating th...
Correction: Reprogramming of Glucose Metabolism by Zerumbone Suppresses Hepatocarcinogenesis
Correction: Reprogramming of Glucose Metabolism by Zerumbone Suppresses Hepatocarcinogenesis
In the original version of this article (1), the same image was inadvertently used to represent arrays for two different g...
Cell-Intrinsic Mechanisms of Drug Tolerance to Systemic Therapies in Cancer
Cell-Intrinsic Mechanisms of Drug Tolerance to Systemic Therapies in Cancer
In patients with cancer with metastatic disease, the rate of complete tumor response to systemic therapies is low, and res...
Current Advances and Trends in KRAS Targeted Therapies for Colorectal Cancer
Current Advances and Trends in KRAS Targeted Therapies for Colorectal Cancer
Kirsten Rat Sarcoma (KRAS) gene somatic point mutations is one of the most prominently mutated proto-oncogenes known to da...
Genomic and Transcriptomic Correlates of Thyroid Carcinoma Evolution after BRAF Inhibitor Therapy
Genomic and Transcriptomic Correlates of Thyroid Carcinoma Evolution after BRAF Inhibitor Therapy
Genomic and Transcriptomic Correlates of Thyroid Carcinoma Evolution after BRAF Inhibitor Therapy ...
GLI3 Is Stabilized by SPOP Mutations and Promotes Castration Resistance via Functional Cooperation with Androgen Receptor in Prostate Cancer
GLI3 Is Stabilized by SPOP Mutations and Promotes Castration Resistance via Functional Cooperation with Androgen Receptor in Prostate Cancer
GLI3 Is Stabilized by SPOP Mutations and Promotes Castration Resistance via Functional Cooperation with...
The Epithelial-Stromal Microenvironment in Early Colonic Neoplasia
The Epithelial-Stromal Microenvironment in Early Colonic Neoplasia
The Epithelial–Stromal Microenvironment in Early Colonic Neoplasia Takayasu Ideta, Boyang Li, Ch...
Centromere Protein A Goes Far Beyond the Centromere in Cancers
Centromere Protein A Goes Far Beyond the Centromere in Cancers
Centromere dysfunctions leading to numerical chromosome alterations are believed to be closely related to human cancers. A...
IQ Motif-Containing GTPase-Activating Protein 2 Inhibits Breast Cancer Angiogenesis by Suppressing VEGFR2-AKT Signaling
IQ Motif-Containing GTPase-Activating Protein 2 Inhibits Breast Cancer Angiogenesis by Suppressing VEGFR2-AKT Signaling
Antiangiogenesis cancer therapies are facing setbacks due to side effects and resistance. Parallel targeting of multiple p...
Regulation of Chemosensitivity in Human Medulloblastoma Cells by p53 and the PI3 Kinase Signaling Pathway
Regulation of Chemosensitivity in Human Medulloblastoma Cells by p53 and the PI3 Kinase Signaling Pathway
AbstractIn medulloblastoma, p53 expression has been associated with chemoresistance and radiation resistance and with poor...
Mutations in Noncoding Cis-Regulatory Elements Reveal Cancer Driver Cistromes in Luminal Breast Cancer
Mutations in Noncoding Cis-Regulatory Elements Reveal Cancer Driver Cistromes in Luminal Breast Cancer
IntroductionBreast cancer is the second leading cause of death in women in North America (1). Currently, treatment decisio...
Heme Sequestration Effectively Suppresses the Development and Progression of Both Lung Adenocarcinoma and Squamous Cell Carcinoma
Heme Sequestration Effectively Suppresses the Development and Progression of Both Lung Adenocarcinoma and Squamous Cell Carcinoma
Lung adenocarcinoma (ADC) and squamous cell carcinoma (SCC) are two most common subtypes of lung cancer. Here, to identify...
A Novel Therapeutic Strategy Targeting the Mesenchymal Phenotype of Malignant Pleural Mesothelioma by Suppressing LSD1
A Novel Therapeutic Strategy Targeting the Mesenchymal Phenotype of Malignant Pleural Mesothelioma by Suppressing LSD1
A Novel Therapeutic Strategy Targeting the Mesenchymal Phenotype of Malignant Pleural Mesothelioma by S...
Epstein-Barr Virus Induces Lymphangiogenesis and Lympth Node Metastasis via Upregulation of VEGF-C in Nasopharyngeal Carcinoma
Epstein-Barr Virus Induces Lymphangiogenesis and Lympth Node Metastasis via Upregulation of VEGF-C in Nasopharyngeal Carcinoma
Epstein-Barr Virus Induces Lymphangiogenesis and Lympth Node Metastasis via Upregulation of VEGF-C in N...
Quantitative Longitudinal Imaging Reveals that Inhibiting Hedgehog Activity Alleviates the Hypoxic Tumor Landscape
Quantitative Longitudinal Imaging Reveals that Inhibiting Hedgehog Activity Alleviates the Hypoxic Tumor Landscape
Quantitative Longitudinal Imaging Reveals that Inhibiting Hedgehog Activity Alleviates the Hypoxic Tumo...
Selected Articles from This Issue
Selected Articles from This Issue
Ge et al. Page 1980Cancer-associated splicing alterations represent a key epigenetic mechanism underlying tumor biological...
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