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Inflammation starves antitumour immunity
Inflammation starves antitumour immunity
When cells sense amino acids, they activate a kinase complex known as mTORC1 in a process that can regulate cancer metabol...
RNA imbalance as a hallmark of cellular ageing
RNA imbalance as a hallmark of cellular ageing
Major advances over the past few decades have highlighted the complex regulation of RNA from transcription to nuclear expo...
High-throughput generation of patient-derived cancer stem cells for precision medicine using a microwell-chip platform
High-throughput generation of patient-derived cancer stem cells for precision medicine using a microwell-chip platform
Substantial evidence indicates that cancer stem cells (CSCs) drive breast cancer (BRC) initiation, progression, therapy re...
Tissue rigidity phase transition shapes morphogen gradients
Tissue rigidity phase transition shapes morphogen gradients
During development, local mechanochemical cues within the cell microenvironment are translated into signalling pathways th...
Fuelling basement membrane invasion
Cell invasion though the basement membranes is an energetically demanding process, but the mechanisms through which cells ...
Alu RNAs organize transcription at speckles
Nuclear speckles are gene expression nodes where transcription and RNA processing take place. Yet, the mechanisms underlyi...
Tracking the fates of cystine in tumours
Tumours can rewire their metabolism due to activation of the transcription factor NRF2. Brain, Vigil et al. explored the m...
Mechanisms and functions of large extracellular vesicle biogenesis
Mechanisms and functions of large extracellular vesicle biogenesis
Owing to the ability of extracellular vesicles (EVs) to encapsulate and transfer biomolecules for intercellular communicat...
ERCC6L2–CtIP condensation tunes end resection
ERCC6L2–CtIP condensation tunes end resection
ATM inhibitors (ATMi) cause cell death by enabling CtIP to induce excessive DNA resection. A study now shows that ERCC6L2 ...
Forcing cell fate
Forcing cell fate
The transition of a pluripotent stem cell into a differentiated lineage is one of the most complex yet precisely orchestra...
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells
Acquisition of specific cell shapes and morphologies is a central component of cell fate transitions. Although signalling ...
Author Correction: ERCC1–XPF cooperates with CTCF and cohesin to facilitate the developmental silencing of imprinted genes
Author Correction: ERCC1–XPF cooperates with CTCF and cohesin to facilitate the developmental silencing of imprinted genes
Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion, Crete, GreeceG...
ER shaping closes the gap in wound healing
ER shaping closes the gap in wound healing
During wound healing, epithelial gaps trigger curvature-dependent ER remodelling. Tubules form at convex cell edges and pr...
Cracking glioblastoma core regulatory codes
Cracking glioblastoma core regulatory codes
Glioblastoma (GBM) heterogeneity might arise because of the activation of various gene core regulatory circuitries (CRCs)....
Defining heterogeneity in core regulatory circuitry reveals HOXB3 condensation as a potential target in glioblastoma
Defining heterogeneity in core regulatory circuitry reveals HOXB3 condensation as a potential target in glioblastoma
Glioblastoma (GBM) exhibits marked heterogeneity, yet therapeutic strategies effectively targeting this variability remain...
Phase-separated NDF−FACT condensates facilitate transcription elongation on chromatin
Phase-separated NDF−FACT condensates facilitate transcription elongation on chromatin
How the facilitates chromatin transcription (FACT) complex enables RNA polymerase II to overcome chromatin barriers in cel...
How a ribosomal protein avoids mixed signals
How a ribosomal protein avoids mixed signals
Accurate protein targeting is a crucial aspect of many biological pathways such as ribosome assembly. Most eukaryotes requ...
Flow, sense and divide
Flow, sense and divide
In each cell division during early embryogenesis, daughter cells acquire half the size of the mother cell. A study now rep...
Functional screen identifies RBM42 as a mediator of oncogenic mRNA translation specificity
Functional screen identifies RBM42 as a mediator of oncogenic mRNA translation specificity
Oncogenic protein dosage is tightly regulated to enable cancer formation but how this is regulated by translational contro...
Time for lipid cell biology
Time for lipid cell biology
It is an exciting time for lipid metabolism and membrane cell biologists as technological progress has increased our abili...
Regulating MYC translation in cancer
Regulating MYC translation in cancer
Layered control of oncogenic protein dosage enables the hallmarks of cancer, but specific regulators of oncogene mRNA tran...
A quantitative ultrastructural timeline of nuclear autophagy reveals a role for dynamin-like protein 1 at the nuclear envelope
A quantitative ultrastructural timeline of nuclear autophagy reveals a role for dynamin-like protein 1 at the nuclear envelope
Autophagic mechanisms that maintain nuclear envelope homoeostasis are bulwarks to ageing and disease. Here we define a qua...
Ribophagy relies on Rpl12
Ribophagy relies on Rpl12
The selective destruction of ribosomal subunits through autophagy (‘ribophagy’) is crucial for maintaining cel...
Rpl12 is a conserved ribophagy receptor
Rpl12 is a conserved ribophagy receptor
Ribophagy is a selective autophagic process that regulates ribosome turnover. Although NUFIP1 has been identified as a mam...
Author Correction: Co-option of epidermal cells enables touch sensing
Author Correction: Co-option of epidermal cells enables touch sensing
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Author Correction: Phase separation of EB1 guides microtubule plus-end dynamics
Author Correction: Phase separation of EB1 guides microtubule plus-end dynamics
These authors contributed equally: Xiaoyu Song, Fengrui Yang, Tongtong Yang, Yong Wang, Mingrui Ding, Linge Li.These autho...
Pyruvate metabolism regulates prostate cell fate and response to cancer therapy
Pyruvate metabolism regulates prostate cell fate and response to cancer therapy
Lineage transitions are a central feature of prostate development, tumorigenesis and treatment resistance. We discovered t...
Metabolically regulated lineages in prostate cancer
Metabolically regulated lineages in prostate cancer
Lineage plasticity and epigenetic changes underlie prostate development and cancer evolution. A new study shows that basal...
Prostate lineage-specific metabolism governs luminal differentiation and response to antiandrogen treatment
Prostate lineage-specific metabolism governs luminal differentiation and response to antiandrogen treatment
Lineage transitions are a central feature of prostate development, tumourigenesis and treatment resistance. While epigenet...
Breast cancer remotely imposes a myeloid bias on haematopoietic stem cells by reprogramming the bone marrow niche
Breast cancer remotely imposes a myeloid bias on haematopoietic stem cells by reprogramming the bone marrow niche
Myeloid cell infiltration of solid tumours generally associates with poor patient prognosis and disease severity1–13...
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