Li Y, Wang G-Q, Li Y-B. Therapeutic potential of natural coumarins in autoimmune diseases with underlying mechanisms. Front Immunol. 2024;15:1432846. https://doi.org/10.3389/fimmu.2024.1432846.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Palomares O, Elewaut D, Irving PM, Jaumont X, Tassinari P. Regulatory T cells and immunoglobulin E: a new therapeutic link for autoimmunity? Allergy. 2022;77:3293–308. https://doi.org/10.1111/all.15449.

Article  PubMed  Google Scholar 

Houen G. Auto-immuno-deficiency syndromes. Autoimmun Rev. 2024;23:103610. https://doi.org/10.1016/j.autrev.2024.103610.

Article  PubMed  CAS  Google Scholar 

Fan Y, Wang Y, Du J, Wu R, Li J, Xiao C, et al. Clinical characteristics and prognostic factors of COVID-19 in rheumatic patients and their family members: a retrospective study. Front Immunol. 2024;15:1439242. https://doi.org/10.3389/fimmu.2024.1439242.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Dao LTM, Vu TT, Nguyen QT, Hoang VT, Nguyen TL. Current cell therapies for systemic lupus erythematosus. Stem Cells Transl Med. 2024;13:859–72. https://doi.org/10.1093/stcltm/szae044.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Petruzzelli R, Polishchuk E, Polishchuk R. Copper in human health and disease: insights from inherited disorders. Physiology. 2025. https://doi.org/10.1152/physiol.00032.2025.

Article  PubMed  PubMed Central  Google Scholar 

Tang D, Kroemer G, Kang R. Targeting cuproplasia and cuproptosis in cancer. Nat Rev, Clin Oncol. 2024;21:370–88. https://doi.org/10.1038/s41571-024-00876-0.

Article  PubMed  CAS  Google Scholar 

Peng J, Dai X, Fan H, Xing C, Zhuang Y, Gao X, et al. Mitochondria-associated endoplasmic reticulum membranes participate mitochondrial dysfunction and endoplasmic reticulum stress caused by copper in duck kidney. Environ Sci Pollut Res. 2023;30:77127–38. https://doi.org/10.1007/s11356-023-27924-z.

Article  CAS  Google Scholar 

Jiang D, Zhuang L, Koong AC, Gan B. Cuproptosis in cancer: from molecular mechanisms to therapeutic intervention. Trends Cancer. 2025;S2405–8033(25):309–17. https://doi.org/10.1016/j.trecan.2025.12.002.

Article  CAS  Google Scholar 

Xiong C, Ling H, Hao Q, Zhou X. Cuproptosis: p53-regulated metabolic cell death? Cell Death Differ. 2023;30:876–84. https://doi.org/10.1038/s41418-023-01125-0.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cheng H, Zhao L, Cai J. Cuproptosis-driven nanostrategies: synergistic nanoplatforms for tumor microenvironment reprogramming and enhanced anticancer efficacy. Mater Today, Bio. 2025;32:101894. https://doi.org/10.1016/j.mtbio.2025.101894.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Boaru DL, Leon-Oliva DD, Castro-Martinez PD, Garcia-Montero C, Fraile-Martinez O, García-González B, et al. Cuproptosis: current insights into its multifaceted role in disease, cancer, and translational/therapeutic opportunities. Biomed Pharmacother. 2025;190:118422. https://doi.org/10.1016/j.biopha.2025.118422.

Article  PubMed  CAS  Google Scholar 

Zhong W, Dong Y, Hong C, Li Y, Xiao C, Liu X, et al. ASH2L upregulation contributes to diabetic endothelial dysfunction in mice through STEAP4-mediated copper uptake. Acta Pharmacol Sin. 2024;45:558–69. https://doi.org/10.1038/s41401-023-01174-8.

Article  PubMed  CAS  Google Scholar 

Guo J, Cheng J, Zheng N, Zhang X, Dai X, Zhang L, et al. Copper promotes tumorigenesis by activating the PDK1-AKT oncogenic pathway in a copper transporter 1 dependent manner. Adv Sci. 2021;8:2004303. https://doi.org/10.1002/advs.202004303.

Article  CAS  Google Scholar 

Das A, Ash D, Fouda AY, Sudhahar V, Kim Y-M, Hou Y, et al. Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis. Nat Cell Biol. 2022;24:35–50. https://doi.org/10.1038/s41556-021-00822-7.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Suwara J, Hartman ML. Balancing between cuproplasia and copper-dependent cell death: molecular basis and clinical implications of ATOX1 in cancer. J Exp Clin Cancer Res : CR. 2025;44:222. https://doi.org/10.1186/s13046-025-03486-5.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhang X, Walke GR, Horvath I, Kumar R, Blockhuys S, Holgersson S, et al. Memo1 binds reduced copper ions, interacts with copper chaperone Atox1, and protects against copper-mediated redox activity in vitro. Proc Natl Acad Sci USA. 2022;119:e2206905119. https://doi.org/10.1073/pnas.2206905119.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ercan H, Reumiller CM, Mühlberger J, Hsu F, Schmidt GJ, Umlauf E, et al. Platelets mirror changes in the frontal lobe antioxidant system in alzheimer’s disease. Alzheimer’s Dement J Alzheimer’s Assoc. 2025;21:e70117. https://doi.org/10.1002/alz.70117.

Article  CAS  Google Scholar 

Lu P, Yan H-J, Yang C, Feng W-C, Hu F, Wu Y-Y, et al. High fat suppresses SOD1 activity by reducing copper chaperone for SOD1 associated with neurodegeneration and memory decline. Life Sci. 2021;272:119243. https://doi.org/10.1016/j.lfs.2021.119243.

Article  PubMed  CAS  Google Scholar 

Nývltová E, Dietz JV, Seravalli J, Khalimonchuk O, Barrientos A. Coordination of metal center biogenesis in human cytochrome c oxidase. Nat Commun. 2022;13:3615. https://doi.org/10.1038/s41467-022-31413-1.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ramchandani D, Berisa M, Tavarez DA, Li Z, Miele M, Bai Y, et al. Copper depletion modulates mitochondrial oxidative phosphorylation to impair triple negative breast cancer metastasis. Nat Commun. 2021;12:7311. https://doi.org/10.1038/s41467-021-27559-z.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhu S, Zhou W, Niu Y, Zheng C, Liu X, Zhang Y, et al. COX17 restricts renal fibrosis development by maintaining mitochondrial copper homeostasis and restoring complex IV activity. Acta Pharmacol Sin. 2023;44:2091–102. https://doi.org/10.1038/s41401-023-01098-3.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Huang D, Chen L, Ji Q, Xiang Y, Zhou Q, Chen K, et al. Lead aggravates alzheimer’s disease pathology via mitochondrial copper accumulation regulated by COX17. Redox Biol. 2023;69:102990. https://doi.org/10.1016/j.redox.2023.102990.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhou D, Zi H, Yang X, Li X, Li Y, Xu A, et al. Dysfunction of ATP7B splicing variant caused by enhanced interaction with COMMD1 in Wilson disease. Cell Mol Gastroenterol Hepatol. 2024;19:101418. https://doi.org/10.1016/j.jcmgh.2024.101418.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Liu Y-T, Chen L, Li S-J, Wang W-Y, Wang Y-Y, Yang Q-C, et al. Dysregulated wnt/β-catenin signaling confers resistance to cuproptosis in cancer cells. Cell Death Differ. 2024;31:1452–66. https://doi.org/10.1038/s41418-024-01341-2.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Du M, Fu J, Zhang J, Zhu Z, Huang X, Tan W, et al. CircSpna2 attenuates cuproptosis by mediating ubiquitin ligase Keap1 to regulate the Nrf2-Atp7b signalling axis in depression after traumatic brain injury in a mouse model. Clin Transl Med. 2024;14:e70100. https://doi.org/10.1002/ctm2.70100.

Article  PubMed  PubMed Central  CAS  Google Scholar