Mobarak H, et al. Prokaryotic microvesicles Ortholog of eukaryotic extracellular vesicles in biomedical fields. Cell Communication Signal. 2024;22(1):80.

Article  Google Scholar 

Gill S, Catchpole R, Forterre P. Extracellular membrane vesicles in the three domains of life and beyond. FEMS Microbiol Rev. 2019;43(3):273–303.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hartmann A, et al. Exosomes and the prion protein: more than one truth. Front NeuroSci. 2017;11:194.

Article  PubMed  PubMed Central  Google Scholar 

Chatterjee K, Gupta ND, De M. Electron microscopic observations on the morphology of Mycobacterium leprae. Exp Cell Res. 1959;18(3):521–7.

Article  CAS  PubMed  Google Scholar 

Hosseini-Giv N, et al. Bacterial extracellular vesicles and their novel therapeutic applications in health and cancer. Front Cell Infect Microbiol. 2022;12:962216.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li N, et al. Efficient isolation of outer membrane vesicles (OMVs) secreted by gram-negative bacteria via a novel gradient filtration method. Membranes. 2024;14(6):135.

Article  PubMed  PubMed Central  Google Scholar 

Mobarak H, et al. Prokaryotic microvesicles Ortholog of eukaryotic extracellular vesicles in biomedical fields. Cell Communication Signal. 2024;22(1):80.

Article  Google Scholar 

Guo J, et al. Opportunities and challenges of bacterial extracellular vesicles in regenerative medicine. J Nanobiotechnol. 2025;23(1):4.

Article  Google Scholar 

Asnicar F, et al. Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals. Nat Med. 2021;27(2):321–32.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zheng D, Liwinski T, Elinav E. Interaction between microbiota and immunity in health and disease. Cell Res. 2020;30(6):492–506.

Article  PubMed  PubMed Central  Google Scholar 

De Filippis F, et al. Dietary interventions to modulate the gut microbiome—how far away are we from precision medicine. Inflamm Bowel Dis. 2018;24(10):2142–54.

Article  PubMed  Google Scholar 

Valdes AM et al. Role of the gut microbiota in nutrition and health. BMJ, 2018. 361.

Boulangé CL, et al. Impact of the gut microbiota on inflammation, obesity, and metabolic disease. Genome Med. 2016;8(1):42.

Article  PubMed  PubMed Central  Google Scholar 

Le Chatelier E, et al. Richness of human gut microbiome correlates with metabolic markers. Nature. 2013;500(7464):541–6.

Article  PubMed  Google Scholar 

Tang WW, et al. Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N Engl J Med. 2013;368(17):1575–84.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Z, et al. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature. 2011;472(7341):57–63.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kaparakis-Liaskos M, Ferrero RL. Immune modulation by bacterial outer membrane vesicles. Nat Rev Immunol. 2015;15(6):375–87.

Article  CAS  PubMed  Google Scholar 

O’donoghue EJ, Krachler AM. Mechanisms of outer membrane vesicle entry into host cells. Cell Microbiol. 2016;18(11):1508–17.

Article  PubMed  PubMed Central  Google Scholar 

Moghaddam ZS, et al. Bacterial extracellular vesicles: bridging pathogen biology and therapeutic innovation. Acta Biomater. 2025;200:1–20.

Article  CAS  PubMed  Google Scholar 

Grahl MV, et al. Microbial trojan horses: virulence factors as key players in neurodegenerative diseases. Molecules. 2025;30(3):687.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu BD, et al. Bacterial extracellular vesicles in the regulation of inflammatory response and host-microbe interactions. Shock. 2024;61(2):175–88.

Article  CAS  PubMed  Google Scholar 

Caruana JC, Walper SA. Bacterial membrane vesicles as mediators of microbe–microbe and microbe–host community interactions. Front Microbiol. 2020;11:432.

Article  PubMed  PubMed Central  Google Scholar 

Jones EJ, et al. The uptake, trafficking, and biodistribution of Bacteroides thetaiotaomicron generated outer membrane vesicles. Front Microbiol. 2020;11:57.

Article  PubMed  PubMed Central  Google Scholar 

Mardi N, et al. Beneficial and challenges of exosome application in ischemic heart disease. Stem Cell Res Ther. 2025;16(1):247.

Article  PubMed  PubMed Central  Google Scholar 

Yu L, et al. Apoptotic bodies: bioactive treasure left behind by the dying cells with robust diagnostic and therapeutic application potentials. J Nanobiotechnol. 2023;21(1):218.

Article  Google Scholar 

Lécrivain A-L, B.M.J.B.e.B.A.-G RM, Beckmann. Bacterial RNA in extracellular vesicles: A new regulator of host-pathogen interactions? 2020. 1863(7):194519.

Humaira et al. Bacterial Extracellular Vesicles: Potential Therapeutic Applications, Challenges, and Future Prospects. 2024. 64(10):e2400221.

Chronopoulos A, Kalluri RJO. Emerg role bacterial Extracell vesicles cancer. 2020;39(46):6951–60.

CAS  Google Scholar 

Gurunathan S, J.-H.J MP, Kim. Bacterial extracellular vesicles: Emerging nanoplatforms for biomedical applications. 2023:106308.

Deng D-K, et al. Roles Extracell vesicles periodontal Homeost their therapeutic potential. 2022;20(1):545.

CAS  Google Scholar 

Luo R et al. Interactions between extracellular vesicles and microbiome in human diseases: New therapeutic opportunities. 2023. 2(2):e86.

Fang Y et al. Biogenesis and biological functions of extracellular vesicles in cellular and organismal communication with microbes. 2022. 13:817844.

Muñoz-Echeverri LM et al. Bacterial extracellular vesicles: biotechnological perspective for enhanced productivity. 2024. 40(6):174.

Toyofuku M et al. Prophage-triggered membrane vesicle formation through peptidoglycan damage in Bacillus subtilis. 2017. 8(1): 481.

Pandey S, Blache A, Achouak WJM. Insights into Bacterial Extracellular Vesicle Biogenesis, Functions, and Implications in Plant–Microbe Interactions. 2024. 12(3):532.

Briaud P, Carroll RKJI, immunity. Extracell vesicle biogenesis Funct gram-positive bacteria. 2020;88(12). https://doi.org/10.1128/iai.00433-20.

Hosseini-Giv N, et al. Bacterial Extracell vesicles their novel therapeutic Appl health cancer. 2022;12:962216.

CAS  Google Scholar 

Cañas M-A, et al. Outer membrane vesicles from probiotic and commensal Escherichia coli activate NOD1-mediated immune responses in intestinal epithelial cells. Front Microbiol. 2018;9:498.

Article  PubMed  PubMed Central  Google Scholar 

Cañas M-A, et al. Outer membrane vesicles from the probiotic Escherichia coli Nissle 1917 and the commensal ECOR12 enter intestinal epithelial cells via clathrin-dependent endocytosis and elicit differential effects on DNA damage. PLoS ONE. 2016;11(8):e0160374.

Article  PubMed  PubMed Central  Google Scholar 

Bielaszewska M, et al. Host cell interactions of outer membrane vesicle-associated virulence factors of enterohemorrhagic Escherichia coli O157: Intracellular delivery, trafficking and mechanisms of cell injury. PLoS Pathog. 2017;13(2):e1006159.

Article  PubMed  PubMed Central  Google Scholar 

Bielaszewska M, et al. Enterohemorrhagic Escherichia coli hemolysin employs outer membrane vesicles to target mitochondria and cause endothelial and epithelial apoptosis. PLoS Pathog. 2013;9(12):e1003797.

Article  PubMed  PubMed Central  Google Scholar 

Kim JH, et al. Outer membrane vesicles derived from Escherichia coli up-regulate expression of endothelial cell adhesion molecules in vitro and in vivo. PLoS ONE. 2013;8(3):e59276.

Article  CAS  PubMed  PubMed Central  Google Scholar