Fu J, Wu H. Structural mechanisms of NLRP3 inflammasome assembly and activation. Annu Rev Immunol. 2023;41:301–16.
Article CAS PubMed PubMed Central Google Scholar
He Y, Hara H, Nunez G. Mechanism and regulation of NLRP3 inflammasome activation. Trends Biochem Sci. 2016;41:1012–21.
Article CAS PubMed PubMed Central Google Scholar
Swanson KV, Deng M, Ting JP. The NLRP3 inflammasome: molecular activation and regulation to therapeutics. Nat Rev Immunol. 2019;19:477–89.
Article CAS PubMed PubMed Central Google Scholar
Huang Y, Xu W, Zhou R. NLRP3 inflammasome activation and cell death. Cell Mol Immunol. 2021;18:2114–27.
Article CAS PubMed PubMed Central Google Scholar
Mangan MSJ, Olhava EJ, Roush WR, Seidel HM, Glick GD, Latz E. Targeting the NLRP3 inflammasome in inflammatory diseases. Nat Rev Drug Discov. 2018;17:588–606.
Article CAS PubMed Google Scholar
Sun T, Xie R, He H, Xie Q, Zhao X, Kang G, et al. Kynurenic acid ameliorates NLRP3 inflammasome activation by blocking calcium mobilization via GPR35. Front Immunol. 2022;13:1019365.
Article CAS PubMed PubMed Central Google Scholar
Vande Walle L, Lamkanfi M. Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets. Nat Rev Drug Discov. 2024;23:43–66.
Article CAS PubMed Google Scholar
Sydnes OA. A clinical investigation of niflumic acid in the treatment of rheumatoid arthritis. Scand J Rheumatol Suppl. 1973;1:8–11.
Article CAS PubMed Google Scholar
White MM, Aylwin M. Niflumic and flufenamic acids are potent reversible blockers of Ca2(+)-activated Cl- channels in Xenopus oocytes. Mol Pharmacol. 1990;37:720–4.
Article CAS PubMed Google Scholar
Liantonio A, Giannuzzi V, Picollo A, Babini E, Pusch M, Conte Camerino D. Niflumic acid inhibits chloride conductance of rat skeletal muscle by directly inhibiting the CLC-1 channel and by increasing intracellular calcium. Br J Pharmacol. 2007;150:235–47.
Article CAS PubMed Google Scholar
Smith CE, Soti S, Jones TA, Nakagawa A, Xue D, Yin H. Non-steroidal anti-inflammatory drugs are caspase inhibitors. Cell Chem Biol. 2017;24:281–92.
Article CAS PubMed PubMed Central Google Scholar
Eisenstein A, Hilliard BK, Pope SD, Zhang C, Taskar P, Waizman DA, et al. Activation of the transcription factor NRF2 mediates the anti-inflammatory properties of a subset of over-the-counter and prescription NSAIDs. Immunity. 2022;55:1082–95. e5.
Article CAS PubMed PubMed Central Google Scholar
Martinon F, Petrilli V, Mayor A, Tardivel A, Tschopp J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature. 2006;440:237–41.
Article CAS PubMed Google Scholar
Mariathasan S, Weiss DS, Newton K, McBride J, O’Rourke K, Roose-Girma M, et al. Cryopyrin activates the inflammasome in response to toxins and ATP. Nature. 2006;440:228–32.
Article CAS PubMed Google Scholar
Shimizu T, Iehara T, Sato K, Fujii T, Sakai H, Okada Y. TMEM16F is a component of a Ca2+-activated Cl- channel but not a volume-sensitive outwardly rectifying Cl- channel. Am J Physiol Cell Physiol. 2013;304:C748–59.
Article CAS PubMed Google Scholar
Lee B, Hong GS, Lee SH, Kim H, Kim A, Hwang EM, et al. Anoctamin 1/TMEM16A controls intestinal Cl(-) secretion induced by carbachol and cholera toxin. Exp Mol Med. 2019;51:1–14.
PubMed PubMed Central Google Scholar
da Costa BR, Reichenbach S, Keller N, Nartey L, Wandel S, Jüni P, et al. Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis. Lancet. 2017;390:E21–33.
Daniels MJ, Rivers-Auty J, Schilling T, Spencer NG, Watremez W, Fasolino V, et al. Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent models. Nat Commun. 2016;7:12504.
Article CAS PubMed PubMed Central Google Scholar
Green JP, Yu S, Martin-Sanchez F, Pelegrin P, Lopez-Castejon G, Lawrence CB, et al. Chloride regulates dynamic NLRP3-dependent ASC oligomerization and inflammasome priming. Proc Natl Acad Sci U S A. 2018;115:E9371–80.
Article CAS PubMed PubMed Central Google Scholar
Wu X, Yi X, Zhao B, Zhi Y, Xu Z, Cao Y, et al. The volume regulated anion channel VRAC regulates NLRP3 inflammasome by modulating itaconate efflux and mitochondria function. Pharmacol Res. 2023;198:107016.
Article CAS PubMed Google Scholar
Green JP, Swanton T, Morris LV, El-Sharkawy LY, Cook J, Yu S et al. LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation. Elife 2020;9:e59704.
Yang G, Tang X, Tan L, Nong D, Yang P, Ning H. Upregulation of miR-144-3p protects myocardial function from ischemia-reperfusion injury through inhibition of TMEM16A Ca(2+)-activated chloride channel. Hum Cell. 2021;34:360–71.
Article CAS PubMed Google Scholar
Cui ZQ, Hu XY, Yang T, Guan JW, Gu Y, Li HY, et al. TMEM16F may be a new therapeutic target for Alzheimer’s disease. Neural Regen Res. 2023;18:643–51.
Article CAS PubMed PubMed Central Google Scholar
Ousingsawat J, Wanitchakool P, Kmit A, Romao AM, Jantarajit W, Schreiber R et al. Anoctamin 6 mediates effects essential for innate immunity downstream of P2X receptors in macrophages. Nat Commun 2015;6:6245.
Karmakar M, Katsnelson MA, Dubyak GR, Pearlman E. Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1beta secretion in response to ATP. Nat Commun. 2016;7:10555.
Article CAS PubMed PubMed Central Google Scholar
Ousingsawat J, Wanitchakool P, Schreiber R, Kunzelmann K. Contribution of TMEM16F to pyroptotic cell death. Cell Death Dis. 2018;9:300.
Article PubMed PubMed Central Google Scholar
Wu N, Cernysiov V, Davidson D, Song H, Tang J, Luo S, et al. Critical role of lipid scramblase TMEM16F in phosphatidylserine exposure and repair of plasma membrane after pore formation. Cell Rep. 2020;30:1129–e11405.
Article CAS PubMed PubMed Central Google Scholar
Pedemonte N, Galietta LJ. Structure and function of TMEM16 proteins (anoctamins). Physiol Rev. 2014;94:419–59.
Article CAS PubMed Google Scholar
Ye Z, Galvanetto N, Puppulin L, Pifferi S, Flechsig H, Arndt M, et al. Structural heterogeneity of the ion and lipid channel TMEM16F. Nat Commun. 2024;15:110.
Article CAS PubMed PubMed Central Google Scholar
Feng S, Puchades C, Ko J, Wu H, Chen Y, Figueroa EE, et al. Identification of a drug binding pocket in TMEM16F calcium-activated ion channel and lipid scramblase. Nat Commun. 2023;14:4874.
Article CAS PubMed PubMed Central Google Scholar
Le T, Jia Z, Le SC, Zhang Y, Chen J, Yang H. An inner activation gate controls TMEM16F phospholipid scrambling. Nat Commun. 2019;10:1846.
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