Strober W, Fuss IJ. Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases. Gastroenterology. 2011;140:1756–67. https://doi.org/10.1053/j.gastro.2011.02.016.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xie Q, Liu X, Liu R, Pan J, Liang J. Cellular mechanisms of combining innate immunity activation with PD-1/PD-L1 blockade in treatment of colorectal cancer. Mol Cancer. 2024. https://doi.org/10.1186/s12943-024-02166-w.

Article  PubMed  PubMed Central  Google Scholar 

Van Kaer L, Algood HMS, Singh K, Parekh VV, Greer MJ, Piazuelo MB, et al. CD8alphaalpha(+) innate-type lymphocytes in the intestinal epithelium mediate mucosal immunity. Immunity. 2014;41:451–64. https://doi.org/10.1016/j.immuni.2014.08.010.

Chou C, Zhang X, Krishna C, Nixon BG, Dadi S, Capistrano KJ et al. Programme of self-reactive innate-like T cell-mediated cancer immunity. Nature. 2022;605:139–145. https://doi.org/10.1038/s41586-022-04632-1

Lee SW, Park HJ, Cheon JH, Wu L, Van Kaer L, Hong S. iNKT Cells suppress pathogenic NK1.1(+)CD8(+) T cells in DSS-induced colitis. Front Immunol. 2018;9:2168. https://doi.org/10.3389/fimmu.2018.02168

Reinhardt RL, Liang HE, Bao K, Price AE, Mohrs M, Kelly BL et al. A novel model for IFN-gamma-mediated autoinflammatory syndromes. J Immunol. 2015;194:2358-68. https://doi.org/10.4049/jimmunol.1401992

Matsuda JL, Gapin L, Baron JL, Sidobre S, Stetson DB, Mohrs M, et al. Mouse V alpha 14i natural killer T cells are resistant to cytokine polarization in vivo. Proc Natl Acad Sci U S A. 2003;100:8395–400. https://doi.org/10.1073/pnas.1332805100.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Van Kaer L, Wu L. Therapeutic potential of invariant natural killer T cells in autoimmunity. Front Immunol. 2018;9:519. https://doi.org/10.3389/fimmu.2018.00519.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Park HJ, Lee SW, Park SH, Van Kaer L, Hong S. Selective expansion of double-negative iNKT cells inhibits the development of atopic dermatitis in Valpha14 TCR transgenic NC/Nga mice by increasing memory-Type CD8(+) T and regulatory CD4(+) T cells. J Invest Dermatol. 2021;141:1512–21. https://doi.org/10.1016/j.jid.2020.09.030.

Article  CAS  PubMed  Google Scholar 

Lebrusant-Fernandez M, Ap Rees T, Jimeno R, Angelis N, Ng JC, Fraternali F, et al. IFN-gamma-dependent regulation of intestinal epithelial homeostasis by NKT cells. Cell Rep. 2024;43:114948. https://doi.org/10.1016/j.celrep.2024.114948.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Y, Sedimbi S, Lofbom L, Singh AK, Porcelli SA, Cardell SL. Unique invariant natural killer T cells promote intestinal polyps by suppressing TH1 immunity and promoting regulatory T cells. Mucosal Immunol. 2018;11:131–143. https://doi.org/10.1038/mi.2017.34

Wang Y, Bhave MS, Yagita H, Cardell SL. Natural killer T-cell agonist alpha-galactosylceramide and PD-1 blockade synergize to reduce tumor development in a preclinical model of colon cancer. Front Immunol. 2020;11:581301. https://doi.org/10.3389/fimmu.2020.581301.

Tang Z, Li C, Kang B, Gao G, Li C, Zhang Z. GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 2017;45:W98–W102. https://doi.org/10.1093/nar/gkx247.

Szklarczyk D, Gable AL, Lyon D, Junge A, Wyder S, Huerta-Cepas J et al. STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res. 2019;47:D607-D613. doi: [10.1093/nar/gky1131].

Kosmidis C, Sapalidis K, Koletsa T, Kosmidou M, Efthimiadis C, Anthimidis G, et al. Interferon-gamma and Colorectal Cancer: an up-to date. J Cancer. 2018;9:232–8. https://doi.org/10.7150/jca.22962.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Du W, Frankel TL, Green M, Zou W. IFNgamma signaling integrity in colorectal cancer immunity and immunotherapy. Cell Mol Immunol. 2022;19:23–32. https://doi.org/10.1038/s41423-021-00735-3

Tang Y, Wei J, Ge X, Yu C, Lu W, Qian Y et al. Intratumoral injection of interferon gamma promotes the efficacy of anti-PD1 treatment in colorectal cancer. Cancer Lett. 2024;588:216798. https://doi.org/10.1016/j.canlet.2024.216798

Choi SH, Kim BG, Robinson J, Fink S, Yan M, Sporn MB, et al. Synthetic triterpenoid induces 15-PGDH expression and suppresses inflammation-driven colon carcinogenesis. J Clin Invest. 2014;124:2472–82. https://doi.org/10.1172/JCI69672

Article  CAS  PubMed  PubMed Central  Google Scholar 

Roberts AI, Lee L, Schwarz E, Groh V, Spies T, Ebert EC, et al. Cutting edge: NKG2D receptors induced by IL-15 costimulate CD28-negative effector CTL in the tissue microenvironment. J Immunol. 2001;167:5527–30. https://doi.org/10.4049/jimmunol.167.10.5527.

Article  CAS  PubMed  Google Scholar 

Zhang C, Zhang J, Niu J, Zhang J, Tian Z. Interleukin-15 improves cytotoxicity of natural killer cells via up-regulating NKG2D and cytotoxic effector molecule expression as well as STAT1 and ERK1/2 phosphorylation. Cytokine. 2008;42:128–36. https://doi.org/10.1016/j.cyto.2008.01.003.

Article  CAS  PubMed  Google Scholar 

Lattanzi G, Strati F, Diaz-Basabe A, Perillo F, Amoroso C, Protti G, et al. iNKT cell-neutrophil crosstalk promotes colorectal cancer pathogenesis. Mucosal Immunol. 2023;16:326–40. https://doi.org/10.1016/j.mucimm.2023.03.006.

Article  CAS  PubMed  Google Scholar 

Lee SW, Park HJ, Kim N, Hong S. Natural Killer Dendritic Cells Enhance Immune Responses Elicited by alpha -Galactosylceramide-Stimulated Natural Killer T Cells. Biomed Res Int. 2013; 2013:460706. https://doi.org/10.1155/2013/460706

Yoshioka K, Ueno Y, Tanaka S, Nagai K, Onitake T, Hanaoka R, et al. Role of natural killer T cells in the mouse colitis-associated colon cancer model. Scand J Immunol. 2012;75:16–26. https://doi.org/10.1111/j.1365-3083.2011.02607.x.

Article  CAS  PubMed  Google Scholar 

Laroui H, Ingersoll SA, Liu HC, Baker MT, Ayyadurai S, Charania MA et al. Dextran sodium sulfate (DSS) induces colitis in mice by forming nano-lipocomplexes with medium-chain-length fatty acids in the colon. PLoS One. 2012; 7:e32084. doi: [10.1371/journal.pone.0032084].

Hosomi S, Grootjans J, Tschurtschenthaler M, Krupka N, Matute JD, Flak MB et al. Intestinal epithelial cell endoplasmic reticulum stress promotes MULT1 up-regulation and NKG2D-mediated inflammation. J Exp Med. 2017;214:2985–2997. https://doi.org/10.1084/jem.20162041

Klingler S, Hsu KS, Hua G, Martin ML, Adileh M, Baslan T et al. Disruption of the crypt niche promotes outgrowth of mutated colorectal tumor stem cells. JCI Insight. 2022;7. https://doi.org/10.1172/jci.insight.153793

Wu B, Zhang B, Li B, Wu H, Jiang M. Cold and hot tumors: from molecular mechanisms to targeted therapy. Signal Transduct Target Ther. 2024. https://doi.org/10.1038/s41392-024-01979-x.

Article  PubMed  PubMed Central  Google Scholar 

Liu YT, Sun ZJ. Turning cold tumors into hot tumors by improving T-cell infiltration. Theranostics. 2021;11:5365–5386. https://doi.org/10.7150/thno.58390

Olszak T, Neves JF, Dowds CM, Baker K, Glickman J, Davidson NO, et al. Protective mucosal immunity mediated by epithelial CD1d and IL-10. Nature. 2014;509:497–502. https://doi.org/10.1038/nature13150

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee SW, Park HJ, Van Kaer L, Hong S. Role of CD1d and iNKT cells in regulating intestinal inflammation. Front Immunol. 2023;14:1343718. https://doi.org/10.3389/fimmu.2023.1343718

Hudson WH, Gensheimer J, Hashimoto M, Wieland A, Valanparambil RM, Li P et al. Proliferating transitory T cells with an effector-like transcriptional signature emerge from PD-1(+) stem-like CD8(+) T cells during chronic infection. Immunity. 2019;51:1043–1058 e4. https://doi.org/10.1016/j.immuni.2019.11.002

Waibl Polania J, Hoyt-Miggelbrink A, Tomaszewski WH, Wachsmuth LP, Lorrey SJ, Wilkinson DS et al. Antigen presentation by tumor-associated macrophages drives T cells from a progenitor exhaustion state to terminal exhaustion. Immunity. 2025;58:232–246 e6. https://doi.org/10.1016/j.immuni.2024.11.026

Kim J, Chang DY, Lee HW, Lee H, Kim JH, Sung PS et al. Innate-like cytotoxic function of bystander-activated CD8(+) T cells is associated with liver injury in acute hepatitis A. Immunity. 2018;48:161–173 e5. https://doi.org/10.1016/j.immuni.2017.11.025

Lee KJ, Choi D, Tae N, Song HW, Kang YW, Lee M, et al. IL-7-primed bystander CD8 tumor-infiltrating lymphocytes optimize the antitumor efficacy of T cell engager immunotherapy. Cell Rep Med. 2024;5:101567. https://doi.org/10.1016/j.xcrm.2024.101567.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Langer V, Vivi E, Regensburger D, Winkler TH, Waldner MJ, Rath T, et al. IFN-gamma drives inflammatory bowel disease pathogenesis through VE-cadherin-directed vascular barrier disruption. J Clin Invest. 2019;129:4691–707. https://doi.org/10.1172/JCI124884

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chu T, Tyznik AJ, Roepke S, Berkley AM, Woodward-Davis A, Pattacini L, et al. Bystander-activated memory CD8 T cells control early pathogen load in an innate-like, NKG2D-dependent manner. Cell Rep. 2013;3:701–8. https://doi.org/10.1016/j.celrep.2013.02.020.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Perez C, Prajapati K, Burke B, Plaza-Rojas L, Zeleznik-Le NJ, Guevara-Patino JA. NKG2D signaling certifies effector CD8 T cells for memory formation. J Immunother Cancer. 2019;7:48. https://doi.org/10.1186/s40425-019-0531-2

Dai C, Lin F, Geng R, Ge X, Tang W, Chang J et al. Implication of combined PD-L1/PD-1 blockade with cytokine-induced killer cells as a synergistic immunotherapy for gastrointestinal cancer. Oncotarget. 2016;7:10332-44. https://doi.org/10.18632/oncotarget.7243