Smith NC, Goulart C, Hayward JA, Kupz A, Miller CM, van Dooren GG. Control of human toxoplasmosis. Int J Parasitol. 2021;51:95–121.
Article CAS PubMed Google Scholar
Matta SK, Rinkenberger N, Dunay IR, Sibley LD. Toxoplasma gondii infection and its implications within the central nervous system. Nat Rev Microbiol. 2021;19:467–80.
Article CAS PubMed Google Scholar
Jiad AL, Ismael MK, Salih TA, Malik SN, Al-Rubaii BAL. Genotyping and evaluation of interleukin-10 and soluble HLA-G in abortion due to toxoplasmosis and HSV-2 infections. Ann Parasitol. 2022;68:385–90.
Wang Y, Zhao X, Li Z, Wang W, Jiang Y, Zhang H, et al. Decidual natural killer cells dysfunction is caused by IDO downregulation in dMDSCs with Toxoplasma gondii infection. Commun Biol. 2024;7:669.
Article CAS PubMed PubMed Central Google Scholar
Wang X, Wang S, Xu X, Jiang Y, Ren L, Zhang H, et al. The effect of Toxoplasma gondii infection on galectin-9 expression in decidual macrophages contributing to dysfunction of decidual NK cells during pregnancy. Parasit Vectors. 2024;17:299.
Article PubMed PubMed Central Google Scholar
Greenbaum S, Averbukh I, Soon E, Rizzuto G, Baranski A, Greenwald NF, et al. A spatially resolved timeline of the human maternal-fetal interface. Nature. 2023;619:595–605.
Article CAS PubMed PubMed Central Google Scholar
Zhang X, Wei H. Role of decidual natural killer cells in human pregnancy and related pregnancy complications. Front Immunol. 2021;12:728291.
Article CAS PubMed PubMed Central Google Scholar
Yang F, Zheng Q, Jin L. Dynamic function and composition changes of immune cells during normal and pathological pregnancy at the maternal-fetal interface. Front Immunol. 2019;10:2317.
Article CAS PubMed PubMed Central Google Scholar
Baalasubramanian S, Harris CL, Donev RM, Mizuno M, Omidvar N, Song WC, et al. CD59a is the primary regulator of membrane attack complex assembly in the mouse. J Immunol. 2004;173:3684–92.
Article CAS PubMed Google Scholar
Bian Q, Chen Y, Zhang J, Du X, Zhou Y, Zhang Q, et al. Maternal natural killer cells drive neuroimmune disorders in offspring through aberrant secretion of extracellular granzyme B. Immunity. 2025;58:1502-1518 e8.
Article CAS PubMed Google Scholar
Li T, Cui L, Xu X, Zhang H, Jiang Y, Ren L, et al. The role of Tim-3 on dNK cells dysfunction during abnormal pregnancy with Toxoplasma gondii infection. Front Cell Infect Microbiol. 2021;11:587150.
Article CAS PubMed PubMed Central Google Scholar
Crncic TB, Laskarin G, Frankovic KJ, Tokmadzic VS, Strbo N, Bedenicki I, et al. Early pregnancy decidual lymphocytes beside perforin use Fas ligand (FasL) mediated cytotoxicity. J Reprod Immunol. 2007;73:108–17.
Article CAS PubMed Google Scholar
Lv M, Jia Y, Dong J, Wu S, Ying H. The landscape of decidual immune cells at the maternal-fetal interface in parturition and preterm birth. Inflamm Res. 2025;74:44.
Article CAS PubMed PubMed Central Google Scholar
Xu X, Zheng G, Ren Y, He X, Peng B, Hu X, et al. A novel 2B4 receptor leads to worse pregnancy outcomes by facilitating TNF-alpha and IFN-gamma production in dNK cells during Toxoplasma gondii infection. Parasit Vectors. 2022;15:337.
Article CAS PubMed PubMed Central Google Scholar
Qi H, Li Y, Liu X, Jiang Y, Li Z, Xu X, et al. Tim-3 regulates the immunosuppressive function of decidual MDSCs via the Fyn-STAT3-C/EBPbeta pathway during Toxoplasma gondii infection. PLoS Pathog. 2023;19:e1011329.
Article CAS PubMed PubMed Central Google Scholar
Guerrero B, Hassouneh F, Delgado E, Casado JG, Tarazona R. Natural killer cells in recurrent miscarriage: an overview. J Reprod Immunol. 2020;142:103209.
Article CAS PubMed Google Scholar
Chen P, Zhou L, Chen J, Lu Y, Cao C, Lv S, et al. The immune atlas of human deciduas with unexplained recurrent pregnancy loss. Front Immunol. 2021;12:689019.
Article CAS PubMed PubMed Central Google Scholar
Ekstrom A, Villoutreix BO, Halperin J, Renstrom E, Blom AM, King BC. CD59 double knockout mice express a CD59ba hybrid fusion protein that mediates insulin secretion. FASEB J. 2024;38:e70156.
Article CAS PubMed Google Scholar
Thornton CA. Immunology of pregnancy. Proc Nutr Soc. 2010;69:357–65.
Article CAS PubMed Google Scholar
Velasquez JA, Burwick RM, Hersh AR, Silva JL, Lenis V, Bernal Y, et al. Plasma CD59 concentrations are increased in preeclampsia with severe features and correlate with laboratory measures of end-organ injury. Pregnancy Hypertens. 2020;22:204–9.
Ueda M, Sato Y, Horie A, Tani H, Miyazaki Y, Okunomiya A, et al. Endovascular trophoblast expresses CD59 to evade complement-dependent cytotoxicity. Mol Cell Endocrinol. 2019;490:57–67.
Article CAS PubMed Google Scholar
Buurma A, Cohen D, Veraar K, Schonkeren D, Claas FH, Bruijn JA, et al. Preeclampsia is characterized by placental complement dysregulation. Hypertension. 2012;60:1332–7.
Article CAS PubMed Google Scholar
Yang YF, Li ZH, Liu TH, Li C, Xie YL, Ge LX, et al. Evaluating the role of DNA methyltransferases in trophoblast fusion and preeclampsia development: insights from methylation-regulated genes. FASEB J. 2024;38:e23706.
Article CAS PubMed Google Scholar
Li L, Ding P, Lv X, Xie S, Li L, Chen J, et al. CD59-regulated Ras compartmentalization orchestrates antitumor T-cell immunity. Cancer Immunol Res. 2022;10:1475–89.
Article CAS PubMed PubMed Central Google Scholar
Shao F, Gao Y, Wang W, He H, Xiao L, Geng X, et al. Silencing EGFR-upregulated expression of CD55 and CD59 activates the complement system and sensitizes lung cancer to checkpoint blockade. Nat Cancer Inst Monogr. 2022;3:1192–210.
Lipp AM, Juhasz K, Paar C, Ogris C, Eckerstorfer P, Thuenauer R, et al. Lck mediates signal transmission from CD59 to the TCR/CD3 pathway in Jurkat T cells. PLoS ONE. 2014;9:e85934.
Article PubMed PubMed Central Google Scholar
Dong J, Cheng XD, Zhang WD, Qin JJ. Recent update on development of small-molecule STAT3 inhibitors for cancer therapy: from phosphorylation inhibition to protein degradation. J Med Chem. 2021;64:8884–915.
Article CAS PubMed Google Scholar
Zhou M, Xu H, Zhang D, Si C, Zhou X, Zhao H, et al. Decreased PIBF1/IL6/p-STAT3 during the mid-secretory phase inhibits human endometrial stromal cell proliferation and decidualization. J Adv Res. 2021;30:15–25.
Article CAS PubMed Google Scholar
Hu C, Wu Z, Huang Z, Hao X, Wang S, Deng J, et al. Nox2 impairs VEGF-A-induced angiogenesis in placenta via mitochondrial ROS-STAT3 pathway. Redox Biol. 2021;45:102051.
Article CAS PubMed PubMed Central Google Scholar
Zhang R, Liu Q, Peng J, Wang M, Gao X, Liao Q, et al. Pancreatic cancer-educated macrophages protect cancer cells from complement-dependent cytotoxicity by up-regulation of CD59. Cell Death Dis. 2019;10:836.
Comments (0)