Xue Y, Chen C, Mi X, et al. Transdermal drug delivery system: current status and clinical application of microneedles. ACS Mater Lett. 2024;6(3):801–21. https://doi.org/10.1021/acsmaterialslett.3c01317

Article  CAS  Google Scholar 

Yao W, Yan X, Xie X, et al. Nanoformulation-assisted microneedle transdermal drug delivery system: an innovative platform enhancing rheumatoid arthritis treatment. Biomed Pharmacother. 2024;178:117219. https://doi.org/10.1016/j.biopha.2024.117219

Article  CAS  Google Scholar 

AL-Japairai KAS, Mahmood S, Almurisi SH, et al. Current trends in polymer microneedle for transdermal drug delivery. Int J Pharm. 2020;587:119673. https://doi.org/10.1016/j.ijpharm.2020.119673

Article  CAS  Google Scholar 

Newell B, Zhan W. Mathematical modelling of microneedle-mediated transdermal delivery of drug nanocarriers into skin tissue and circulatory system. J Controlled Release. 2023;360:447–467. https://doi.org/10.1016/j.jconrel.2023.07.011

Article  CAS  Google Scholar 

Cheng T, Tai Z, Shen M, et al. Advance and challenges in the treatment of skin diseases with the transdermal drug delivery system. Pharmaceutics. 2023;15(8):2165. https://doi.org/10.3390/pharmaceutics15082165.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ramadon D, McCrudden MTC, Courtenay AJ, et al. Enhancement strategies for transdermal drug delivery systems: current trends and applications. Drug Delivery Translational Res. 2022;12(4):758–91. https://doi.org/10.1007/s13346-021-00909-6

Article  Google Scholar 

Zhang R, Miao Q, Deng D, et al. Research progress of advanced microneedle drug delivery system and its application in biomedicine. Colloids Surf B: Biointerfaces. 2023;226:113302. https://doi.org/10.1016/j.colsurfb.2023.113302.

Article  CAS  PubMed  Google Scholar 

Su T, Tang Z, Hu J, et al. Innovative freeze-drying technique in the fabrication of dissolving microneedle patch: enhancing transdermal drug delivery efficiency. Drug Delivery Translational Res. 2024;14(11):3112–27. https://doi.org/10.1007/s13346-024-01531-y.

Article  CAS  Google Scholar 

Dave R, Shinde S, Kalayil N, et al. Engineering microscopic delivery systems: a review of dissolving microneedle design, fabrication, and function. Micro Nano Syst Lett. 2024;12(1):14. https://doi.org/10.1186/s40486-024-00204-2.

Article  Google Scholar 

Rad ZF, Prewett PD, Davies GJ. An overview of microneedle applications, materials, and fabrication methods. Beilstein J Nanotechnol. 2021;12(1):1034–46. https://doi.org/10.3762/bjnano.12.77.

Article  CAS  Google Scholar 

Yadav PR, Hingonia P, Das DB, et al. Modeling of dissolving microneedle-based transdermal drug delivery: effects of dynamics of polymers in solution. Mol Pharm. 2024;21(10):5104–14. https://doi.org/10.1021/acs.molpharmaceut.4c00492.

Article  CAS  PubMed  Google Scholar 

Paris JL, Vora LK, Perez-Moreno AM, et al. Dissolving microneedle array patches containing mesoporous silica nanoparticles of different pore sizes as a tunable sustained release platform. Int J Pharm. 2025;669:125064. https://doi.org/10.1016/j.ijpharm.2024.125064.

Article  CAS  PubMed  Google Scholar 

Aisyah AN, Permana AD, Wahyudin E, et al. Formulation and evaluation of dissolving microneedle for transdermal delivery of piperine: the effect of polymers concentration. J Biomater Sci Polym Ed. 2024;35(8):1177–96. https://doi.org/10.1080/09205063.2024.2320948.

Article  CAS  PubMed  Google Scholar 

Zhang L, Guo R, Wang S, et al. Fabrication, evaluation and applications of dissolving microneedles. Int J Pharm. 2021;604:120749. https://doi.org/10.1016/j.ijpharm.2021.120749.

Article  CAS  PubMed  Google Scholar 

Yao G, Quan G, Lin S, et al. Novel dissolving microneedles for enhanced transdermal delivery of levonorgestrel: in vitro and in vivo characterization. Int J Pharm. 2017;534(1–2):378–86. https://doi.org/10.1016/j.ijpharm.2017.10.035.

Article  CAS  PubMed  Google Scholar 

Chen M, Quan G, Sun Y, et al. Nanoparticles-encapsulated polymeric microneedles for transdermal drug delivery. J Controlled Release. 2020;325:163–75. https://doi.org/10.1016/j.jconrel.2020.06.039.

Article  CAS  Google Scholar 

Cheng A, Zhang S, Meng F, et al. Nanosuspension-loaded dissolving microneedle patches for enhanced transdermal delivery of a highly lipophilic cannabidiol. Int J Nanomed. 2024;19:4061–79. https://doi.org/10.2147/IJN.S452207.

Article  CAS  Google Scholar 

De Oliveira TC, Tavares ME, Soares-Sobrinho JL, et al. The role of nanocarriers for transdermal application targeted to lymphatic drug delivery: opportunities and challenges. J Drug Deliv Sci Technol. 2022;68:103110. https://doi.org/10.1016/j.jddst.2022.103110.

Article  CAS  Google Scholar 

Kheirieh A, Abbasi A, Malaekeh-Nikouei B, et al. Delivery of nanocarriers with dissolvable microneedles for skin treatments: approaches and challenges. J Drug Deliv Sci Technol. 2025;107:106836. https://doi.org/10.1016/j.jddst.2025.106836.

Article  CAS  Google Scholar 

Xie R, Li W, Shi K, et al. Versatile platforms of microneedle patches loaded with responsive nanoparticles: synthesis and promising biomedical applications. Adv NanoBiomed Res. 2024;4(4):2300142. https://doi.org/10.1002/anbr.202300142.

Article  CAS  Google Scholar 

Chang Z, Wu Y, Chen Y, et al. Biological fate tracking of nitric oxide-propelled microneedle delivery system using an aggregation-caused quenching probe. Mol Pharm. 2024;21(9):4541–52. https://doi.org/10.1021/acs.molpharmaceut.4c00435.

Article  CAS  PubMed  Google Scholar 

Wang X, Huang J, Guo M, et al. Aggregation-caused quenching dyes as potent tools to track the integrity of antitumor nanocarriers: a mini-review. Pharmaceuticals. 2025;18(2):176. https://doi.org/10.3390/ph18020176.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang J, Dong Z, Liu W, et al. Discriminating against injectable fat emulsions with similar formulation based on water quenching fluorescent probe. Chin Chem Lett. 2020;31(3):875–9. https://doi.org/10.1016/j.cclet.2019.07.016.

Article  CAS  Google Scholar 

Wang W, Yang B, Huang Z, et al. Investigating the effect of particle size on cellular uptake by aggregation-caused quenching probe–encapsulating solid lipid nanoparticles, inhaled. J Pharm Innov. 2022;17(4):1109–15. https://doi.org/10.1007/s12247-021-09576-z.

Article  Google Scholar 

Shi C, Yang D, Zhao Y, et al. The spatial-dimensional and temporal-dimensional fate of nanocarrier-loaded dissolving microneedles with different lengths of needles. Med Drug Discovery. 2022;14:100124. https://doi.org/10.1016/j.medidd.2022.100124.

Article  CAS  Google Scholar 

Fu Y, Shi C, Li X, et al. Demonstrating biological fate of nanoparticle-loaded dissolving microneedles with aggregation-caused quenching probes: influence of application sites. Pharmaceutics. 2023;15(1):169. https://doi.org/10.3390/pharmaceutics15010169.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cong J, Zheng Z, Fu Y, et al. Spatiotemporal fate of nanocarriers-embedded dissolving microneedles: the impact of needle dissolving rate. Expert Opin Drug Deliv. 2024;21(6):965–74. https://doi.org/10.1080/17425247.2024.2375385.

Article  CAS  PubMed  Google Scholar 

Qu F, Sun Y, Bi D, et al. Regulating size and charge of liposomes in microneedles to enhance intracellular drug delivery efficiency in skin for psoriasis therapy. Adv Healthc Mater. 2023;12(31):e2302314. https://doi.org/10.1002/adhm.202302314

Article  CAS  PubMed  Google Scholar 

Xia F, Fan W, Jiang S, et al. Size-dependent translocation of nanoemulsions via oral delivery. ACS Appl Mater Interfaces. 2017;9(26):21660–72. https://doi.org/10.1021/acsami.7b04916

Article  CAS  PubMed  Google Scholar 

Mota WS, Severino P, Kadian V, et al. Nanometrology: particle sizing and influence on the toxicological profile. Front Nanatechnol. 2025;7:1479464. https://doi.org/10.3389/fnano.2025.1479464

Article  Google Scholar