Boboltz A, Kumar S, Duncan GA. Inhaled drug delivery for the targeted treatment of asthma. Adv Drug Deliv Rev. 2023;198:114858. https://doi.org/10.1016/j.addr.2023.114858.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Duncan GA, Jung J, Hanes J, Suk JS. The mucus barrier to inhaled gene therapy. Mol Ther. 2016;24:2043–53. https://doi.org/10.1038/mt.2016.182.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Winkler J, Hochhaus G, Derendorf H. How the lung handles drugs: Pharmacokinetics and pharmacodynamics of inhaled corticosteroids. Proc Am Thorac Soc. 2004;1:356–63. https://doi.org/10.1513/pats.200403-025MS.

Article  CAS  PubMed  Google Scholar 

Goldin J, Cataletto ME, Asthma P. 2024 [cited 2026 Apr 22]. https://www.ncbi.nlm.nih.gov/books/NBK430901/. Accessed 22 Apr 2026.

Alkilani AZ, Nasereddin J, Hamed R, Nimrawi S, Hussein G, Abo-Zour H, et al. Beneath the skin: A review of current trends and future prospects of transdermal drug delivery systems. Pharmaceutics. 2022;14:1152. https://doi.org/10.3390/pharmaceutics14061152.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alkilani AZ, McCrudden MTC, Donnelly RF. Transdermal drug delivery: Innovative pharmaceutical developments based on disruption of the barrier properties of the stratum corneum. Pharm Multidisciplinary Digit Publishing Inst. 2015;7:438–70. https://doi.org/10.3390/pharmaceutics7040438.

Article  CAS  Google Scholar 

Tabish SA. Complementary and alternative healthcare: Is it evidence-based? Int J Health Sci (Qassim). 2008;2:V–IX.

PubMed  PubMed Central  Google Scholar 

Chan K, Zhang H, Lin Z-X. An overview on adverse drug reactions to traditional Chinese medicines. Br J Clin Pharmacol. 2015;80:834–43. https://doi.org/10.1111/bcp.12598.

Article  PubMed  PubMed Central  Google Scholar 

Xie X, Xu D, Zhuang L, Liu H, Tan S, Lu Y, et al. Sanfu herbal patch applied at acupoints in patients with bronchial asthma: Study protocol for a randomized controlled trial. Trials. 2020;21:684. https://doi.org/10.1186/s13063-020-04604-8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhu L, Zhang W, Wong V, Eric Z, Lao L, Lo K, et al. Randomized trial of acupoints herbal patching in sanfu days for asthma in clinical remission stage. Clin Trans Med. 2016;5:5. https://doi.org/10.1186/s40169-016-0084-7.

Article  Google Scholar 

Prausnitz MR, Mitragotri S, Langer R. Current status and future potential of transdermal drug delivery. Nat Rev Drug Discov Nat Publishing Group. 2004;3:115–24. https://doi.org/10.1038/nrd1304.

Article  CAS  Google Scholar 

Zhao Y, Chen Y-S, Gao H-Y, Gao R, Li B. [systematic review and meta-analysis of safety of sanfu acupoint herbal patching in randomized controlled trial]. Zhongguo Zhong Yao Za Zhi. 2021;46:1276–83. https://doi.org/10.19540/j.cnki.cjcmm.20200730.501.

Article  CAS  PubMed  Google Scholar 

Li W, Lv Y, Liao W, Jiang H, Liu Y, Lu W, et al. Composition, skin pharmacokinetics, and pharmacological effects of the sanfu herbal patch. Natural Product Communications. Volume 19. SAGE Publications Inc; 2024. p. 1934578X241266414. https://doi.org/10.1177/1934578X241266414.

Guan H, Lin Q, Ma C, Ju Z, Wang C. Metabolic profiling and pharmacokinetic studies of sinapine thiocyanate by UHPLC-Q/TOF-MS and UHPLC-MS/MS. J Pharm Biomed Anal. 2022;207:114431. https://doi.org/10.1016/j.jpba.2021.114431.

Article  CAS  PubMed  Google Scholar 

Constituents of aromatic plants: I. Methyleugenol. Fitoterapia Elsevier. 2000;71:216–21. https://doi.org/10.1016/S0367-326X(99)00150-1.

Article  Google Scholar 

Dang R, Xie Z, Cai F, Sun X, Fang Q, Wang G, et al. Revealing the mechanism of sanfu patch dorsal application for alleviating OVA-induced asthma: An integrated approach combining TMT quantitative proteomics and molecular docking. J Ethnopharmacol. 2025;348:119867. https://doi.org/10.1016/j.jep.2025.119867.

Article  CAS  PubMed  Google Scholar 

Lima CC, Criddle DN, Coelho-de-Souza AN, Monte FJ, Jaffar M, Leal-Cardoso JH. Relaxant and antispasmodic actions of methyleugenol on guinea-pig isolated ileum. Planta Med. 2000;66:408–11. https://doi.org/10.1055/s-2000-8594.

Article  CAS  PubMed  Google Scholar 

Zhou J, Ma X, Cui Y, Song Y, Yao L, Liu Y, et al. Methyleugenol protects against t-BHP-triggered oxidative injury by induction of Nrf2 dependent on AMPK/GSK3β and ERK activation. J Pharmacol Sci. 2017;135:55–63. https://doi.org/10.1016/j.jphs.2017.09.003.

Article  CAS  PubMed  Google Scholar 

Yu Y, Wang Y, Yang Z, Li Z, Lu D, Nan X. Methyleugenol alleviates pulmonary vascular remodeling in rats with high-altitude pulmonary hypertension by improving pulmonary smooth muscle cell function. Biomed Pharmacother. 2025;187:118109. https://doi.org/10.1016/j.biopha.2025.118109.

Article  CAS  PubMed  Google Scholar 

Li Z, Zheng J, Zhang N, Li C. Berberine improves airway inflammation and inhibits NF-κB signaling pathway in an ovalbumin-induced rat model of asthma. J Asthma. 2016;53:999–1005. https://doi.org/10.1080/02770903.2016.1180530.

Article  CAS  PubMed  Google Scholar 

Jin H, Li J, Zhang M, Luo R, Lu P, Zhang W et al. Berberine-loaded biomimetic nanoparticles attenuate inflammation of experimental allergic asthma via enhancing IL-12 expression. Front Pharmacol [Internet]. Frontiers; 2021 [cited 2026 July 2];12. https://doi.org/10.3389/fphar.2021.724525

Yu J, Zhao L, Liu L, Yang F, Zhu X, Cao B. Tetrahydropalmatine protects rat pulmonary endothelial cells from irradiation-induced apoptosis by inhibiting oxidative stress and the calcium sensing receptor/phospholipase C-γ1 pathway. Free Radical Res Taylor Francis. 2016;50:611–26. https://doi.org/10.3109/10715762.2016.1154549.

Article  CAS  Google Scholar 

Ding K, Chen L, He J, Wang J, Yu C, Wang H. Tetrahydropalmatine alleviates hyperlipidemia by regulating lipid peroxidation, endoplasmic reticulum stress, and inflammasome activation by inhibiting the TLR4-NF‐κB pathway. [cited 2026 July 2]; https://doi.org/10.1155/2021/6614985

Firoozabadi MD, Nooralishahi B, Rezaei-Tazangi F. Dehydrocorydaline can be a suitable candidate for analgesic purposes: A review on the current preclinical evidence. Mol Pain. 2025;21:17448069251380033. https://doi.org/10.1177/17448069251380033.

Article  CAS  Google Scholar 

Matsuda H, Tokuoka K, Wu J, Shiomoto H, Kubo M. Inhibitory effects of dehydrocorydaline isolated from corydalis tuber against type I-IV allergic models. Biol Pharm Bull. 1997;20:431–4. https://doi.org/10.1248/bpb.20.431.

Article  CAS  PubMed  Google Scholar 

TH1/TH. 2 chemokines/cytokines profile in rats treated with tetanus toxoid and euphorbia tirucalli. Saudi J Biol Sci Elsevier. 2019;26:1716–23. https://doi.org/10.1016/j.sjbs.2018.08.005.

Article  CAS  Google Scholar 

Zhao L, Chen J, Bai B, Song G, Zhang J, Yu H, et al. Topical drug delivery strategies for enhancing drug effectiveness by skin barriers, drug delivery systems and individualized dosing. Front Pharmacol [Internet] Front. 2024. https://doi.org/10.3389/fphar.2023.1333986. [cited 2026 Apr 22];14.

Article  Google Scholar 

Nastiti CMRR, Ponto T, Abd E, Grice JE, Benson HAE, Roberts MS. Topical nano and microemulsions for skin delivery. Pharmaceutics. 2017;9:37. https://doi.org/10.3390/pharmaceutics9040037.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pünnel LC, Lunter DJ. Film-forming systems for dermal drug delivery. Pharmaceutics. 2021;13:932. https://doi.org/10.3390/pharmaceutics13070932.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Neubert RHH. Mechanisms of penetration and diffusion of drugs and cosmetic actives across the human stratum corneum. Eur J Pharm Biopharm. 2024;202:114394. https://doi.org/10.1016/j.ejpb.2024.114394.

Article  CAS  PubMed  Google Scholar 

Nguyen HX, Banga AK. Advanced transdermal drug delivery system: A comprehensive review of microneedle technologies, novel designs, diverse applications, and critical challenges. Int J Pharm. 2025;670:125118. https://doi.org/10.1016/j.ijpharm.2024.125118.

Article  CAS  PubMed  Google Scholar 

Khalid R, Mahmood S, Mohamed Sofian Z, Hilles AR, Hashim NM, Ge Y. Microneedles and their application in transdermal delivery of antihypertensive drugs—a review. Pharm Multidisciplinary Digit Publishing Inst. 2023;15:2029. https://doi.org/10.3390/pharmaceutics15082029.

Article