Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209–49.
Xie S, Wu Z. The metastasizing mechanisms of lung cancer: Recent advances and therapeutic challenges. Biomed Pharmacother. 2021;138:111450.
Article CAS PubMed Google Scholar
Schabath MB, Cote ML. Cancer Progress and Priorities: Lung Cancer. Cancer Epidemiol Biomarkers Prev. 2019;28(10):1563–79.
Article PubMed PubMed Central Google Scholar
Maemondo M, Inoue A, Kobayashi K, et al. Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Engl J Med. 2010;362(25):2380–8.
Article CAS PubMed Google Scholar
Mitsudomi T, Morita S, Yatabe Y, et al. Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial. Lancet Oncol. 2010;11(2):121–8.
Article CAS PubMed Google Scholar
Mok TS, Wu YL, Thongprasert S, et al. Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med. 2009;361(10):947–57.
Article CAS PubMed Google Scholar
Jakobsen KR, Demuth C. The role of epithelial to mesenchymal transition in resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer. Transl Lung Cancer Res. 2016;5(2):172–82.
Article CAS PubMed PubMed Central Google Scholar
Stewart EL, Tan SZ. Known and putative mechanisms of resistance to EGFR targeted therapies in NSCLC patients with EGFR mutations-a review. Transl Lung Cancer Res. 2015;4(1):67–81.
CAS PubMed PubMed Central Google Scholar
Lu S, Wu L, Jian H, et al. Sintilimab plus chemotherapy for patients with EGFR-mutated non-squamous non-small-cell lung cancer with disease progression after EGFR tyrosine-kinase inhibitor therapy (ORIENT-31): second interim analysis from a double-blind, randomised, placebo-controlled, phase 3 trial. Lancet Respir Med. 2023;11(7):624–36.
Article CAS PubMed Google Scholar
Fang W, Zhao Y, Luo Y, et al. Ivonescimab Plus Chemotherapy in Non-Small Cell Lung Cancer With EGFR Variant: A Randomized Clinical Trial. JAMA. 2024;332(7):561–70.
Article CAS PubMed PubMed Central Google Scholar
Zhou J, Hu Q, Zhang X, et al. Sensitivity to chemotherapeutics of NSCLC cells with acquired resistance to EGFR-TKIs is mediated by T790M mutation or epithelial-mesenchymal transition. Oncol Rep. 2018;39(4):1783–92.
Spengler G, Takács D, Horváth A, et al. Multidrug resistance reversing activity of newly developed phenothiazines on P-glycoprotein (ABCB1)-related resistance of mouse T-lymphoma cells. Anticancer Res. 2014;34(4):1737–41.
Shah D, Ajazuddin, Bhattacharya S. Role of natural P-gp inhibitor in the effective delivery for chemotherapeutic agents. J Cancer Res Clin Oncol. 2023;149(1):367–91.
Article CAS PubMed Google Scholar
Dickerson H, Diab A. Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Cancer: Current Use and Future Prospects. Int J Mol Sci. 2024;25:18.
Yin W, Xiang D, Wang T, et al. The inhibition of ABCB1/MDR1 or ABCG2/BCRP enables doxorubicin to eliminate liver cancer stem cells. Sci Rep. 2021;11(1):10791.
Article CAS PubMed PubMed Central Google Scholar
Creemers SG, van Koetsveld PM, De Herder WW, et al. MDR1 inhibition increases sensitivity to doxorubicin and etoposide in adrenocortical cancer. Endocr Relat Cancer. 2019;26(3):367–78.
Article CAS PubMed Google Scholar
Traber GM, Yu AM. RNAi-Based Therapeutics and Novel RNA Bioengineering Technologies. J Pharmacol Exp Ther. 2023;384(1):133–54.
Article CAS PubMed Google Scholar
Zhang H, Xu H. Chemical molecular-based approach to overcome multidrug resistance in cancer by targeting P-glycoprotein (P-gp). Med Res Rev. 2021;41(1):525–55.
Article CAS PubMed Google Scholar
Wallen M, Aqil F. Milk/colostrum exosomes: A nanoplatform advancing delivery of cancer therapeutics. Cancer Lett. 2023;561:216141.
Article CAS PubMed PubMed Central Google Scholar
Xu Z, Wang L, Tu L, et al. Folic Acid-Modified Milk Exosomes Delivering c-Kit siRNA Overcome EGFR-TKIs Resistance in Lung Cancer by Suppressing mTOR Signaling and Stemness. Int J Biol Sci. 2025;21(1):382–99.
Article CAS PubMed PubMed Central Google Scholar
Zheng Z, Li Z. Folate-displaying exosome mediated cytosolic delivery of siRNA avoiding endosome trapping. J Control Release. 2019;311–312:43–9.
Article PubMed PubMed Central Google Scholar
Barok M, Puhka M. Cancer-derived exosomes from HER2-positive cancer cells carry trastuzumab-emtansine into cancer cells leading to growth inhibition and caspase activation. BMC Cancer. 2018;18(1):504.
Article PubMed PubMed Central Google Scholar
Kamerkar S, LeBleu VS, Sugimoto H, et al. Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer. Nature. 2017;546(7659):498–503.
Article CAS PubMed PubMed Central Google Scholar
Limoni SK, Moghadam MF. Engineered Exosomes for Targeted Transfer of siRNA to HER2 Positive Breast Cancer Cells. Appl Biochem Biotechnol. 2019;187(1):352–64.
Article CAS PubMed Google Scholar
Mulcahy LA, Pink RC, Carter DR. Routes and mechanisms of extracellular vesicle uptake. J Extracell Vesicles. 2014;4:3.
González-Sarrías A, Iglesias-Aguirre CE, Cortés-Martín A, et al. Milk-Derived Exosomes as Nanocarriers to Deliver Curcumin and Resveratrol in Breast Tissue and Enhance Their Anticancer Activity. Int J Mol Sci. 2022;23(5):2860.
Article PubMed PubMed Central Google Scholar
Pullan J, Dailey K, Bhallamudi S, et al. Modified Bovine Milk Exosomes for Doxorubicin Delivery to Triple-Negative Breast Cancer Cells. ACS Appl Bio Mater. 2022;5(5):2163–75.
Article CAS PubMed PubMed Central Google Scholar
Li D, Gong L, Lin H, et al. Hyaluronic Acid-Coated Bovine Milk Exosomes for Achieving Tumor-Specific Intracellular Delivery of miRNA-204. Cells. 2022;11(19):3065.
Article CAS PubMed PubMed Central Google Scholar
Li H, Sun Y, Wang J, et al. Hyaluronic acid-modified milk exosomes carrying ZNF516 inhibit ABCC5 and contribute to pemetrexed sensitivity in lung adenocarcinoma. Hum Cell. 2025;38(3):92.
Zhang A, Huang J, Liu Y, et al. Hyaluronic acid application strategies for plant bioactive component delivery: A review. Int J Biol Macromol. 2024;282(Pt 3):137129.
Article CAS PubMed Google Scholar
Del Pozo-Acebo L, Hazas MLL, Tomé-Carneiro J, et al. Bovine Milk-Derived Exosomes as a Drug Delivery Vehicle for miRNA-Based Therapy. Int J Mol Sci. 2021;22(3):1105.
Article PubMed PubMed Central Google Scholar
Reita D, Pabst L, Pencreach E, et al. Molecular Mechanism of EGFR-TKI Resistance in EGFR-Mutated Non-Small Cell Lung Cancer: Application to Biological Diagnostic and Monitoring. Cancers (Basel). 2021;13(19):4926.
Comments (0)