Tumour-associated macrophage infiltration differs in meningioma genotypes, and is important in tumour dynamics

Ogasawara C, Philbrick BD, Adamson DC, Meningioma. A review of epidemiology, pathology, diagnosis, treatment, and future directions. Biomedicines. 2021;9(3).

Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, et al. The 2021 WHO classification of tumors of the central nervous system: a summary. Neuro Oncol. 2021;23(8):1231–51.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Smith HL, Wadhwani N, Horbinski C. Major features of the 2021 WHO classification of CNS tumors. Neurotherapeutics. 2022;19(6):1691–704.

Article  PubMed  PubMed Central  Google Scholar 

Costanzo R, Simonetta I, Musso S, Benigno UE, Cusimano LM, Giovannini EA, et al. Role of mediterranean diet in the development and recurrence of meningiomas: a narrative review. Neurosurg Rev. 2023;46(1):255.

Article  PubMed  PubMed Central  Google Scholar 

Suppiah S, Nassiri F, Bi WL, Dunn IF, Hanemann CO, Horbinski CM, et al. Molecular and translational advances in meningiomas. Neuro Oncol. 2019;21(Suppl 1):i4–17.

Article  PubMed  PubMed Central  Google Scholar 

Wang JZ, Landry AP, Raleigh DR, Sahm F, Walsh KM, Goldbrunner R, et al. Meningioma: international consortium on meningiomas consensus review on scientific advances and treatment paradigms for clinicians, researchers, and patients. Neuro Oncol. 2024;26(10):1742–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Clark VE, Erson-Omay EZ, Serin A, Yin J, Cotney J, Ozduman K, et al. Genomic analysis of non-NF2 meningiomas reveals mutations in TRAF7, KLF4, AKT1, and SMO. Science. 2013;339(6123):1077–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sahm F, Schrimpf D, Stichel D, Jones DTW, Hielscher T, Schefzyk S, et al. DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis. Lancet Oncol. 2017;18(5):682–94.

Article  CAS  PubMed  Google Scholar 

Nassiri F, Liu J, Patil V, Mamatjan Y, Wang JZ, Hugh-White R, et al. A clinically applicable integrative molecular classification of meningiomas. Nature. 2021;597(7874):119–25.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Choudhury A, Magill ST, Eaton CD, Prager BC, Chen WC, Cady MA, et al. Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities. Nat Genet. 2022;54(5):649–59.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bayley JCt, Hadley CC, Harmanci AO, Harmanci AS, Klisch TJ, Patel AJ. Multiple approaches converge on three biological subtypes of meningioma and extract new insights from published studies. Sci Adv. 2022;8(5):eabm6247.

Article  Google Scholar 

Goldbrunner R, Stavrinou P, Jenkinson MD, Sahm F, Mawrin C, Weber DC, et al. EANO guideline on the diagnosis and management of meningiomas. Neuro Oncol. 2021;23(11):1821–34.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brastianos PK, Kim AE, Giobbie-Hurder A, Lee EQ, Wang N, Eichler AF, et al. Phase 2 study of pembrolizumab in patients with recurrent and residual high-grade meningiomas. Nat Commun. 2022;13(1):1325.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bi WL, Nayak L, Meredith DM, Driver J, Du Z, Hoffman S, et al. Activity of PD-1 Blockade with nivolumab among patients with recurrent atypical/anaplastic meningioma: phase II trial results. Neuro Oncol. 2022;24(1):101–13.

Article  CAS  PubMed  Google Scholar 

Garzon-Muvdi T, Bailey DD, Pernik MN, Pan E. Basis for immunotherapy for treatment of meningiomas. Front Neurol. 2020;11:945.

Article  PubMed  PubMed Central  Google Scholar 

Xiao Y, Yu D. Tumor microenvironment as a therapeutic target in cancer. Pharmacol Ther. 2021;221:107753.

Article  CAS  PubMed  Google Scholar 

Proctor DT, Huang J, Lama S, Albakr A, Van Marle G, Sutherland GR. Tumor-associated macrophage infiltration in meningioma. Neurooncol Adv. 2019;1(1):vdz018.

PubMed  PubMed Central  Google Scholar 

Chen X, Tian F, Lun P, Feng Y. Profiles of immune infiltration and its relevance to survival outcome in meningiomas. Biosci Rep. 2020;40(5).

Borch JS, Haslund-Vinding J, Vilhardt F, Maier AD, Mathiesen T. Meningioma-Brain crosstalk: A scoping review. Cancers (Basel). 2021;13(17).

Presta I, Guadagno E, Di Vito A, Malara N, Mignogna C, Maisano D, et al. Innate immunity May play a role in growth and relapse of chordoid meningioma. Int J Immunopathol Pharmacol. 2017;30(4):429–33.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Prinz M, Jung S, Priller J. Microglia biology: one century of evolving concepts. Cell. 2019;179(2):292–311.

Article  CAS  PubMed  Google Scholar 

Matias D, Balça-Silva J, da Graça GC, Wanjiru CM, Macharia LW, Nascimento CP, et al. Microglia/Astrocytes-Glioblastoma crosstalk: crucial molecular mechanisms and microenvironmental factors. Front Cell Neurosci. 2018;12:235.

Article  PubMed  PubMed Central  Google Scholar 

Haslund-Vinding J, Møller JR, Ziebell M, Vilhardt F, Mathiesen T. The role of systemic inflammatory cells in meningiomas. Neurosurg Rev. 2022;45(2):1205–15.

Article  PubMed  Google Scholar 

Li YD, Veliceasa D, Lamano JB, Lamano JB, Kaur G, Biyashev D, et al. Systemic and local immunosuppression in patients with high-grade meningiomas. Cancer Immunol Immunother. 2019;68(6):999–1009.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fang L, Lowther DE, Meizlish ML, Anderson RC, Bruce JN, Devine L, et al. The immune cell infiltrate populating meningiomas is composed of mature, antigen-experienced T and B cells. Neuro Oncol. 2013;15(11):1479–90.

Article  CAS  PubMed  PubMed Central  Google Scholar 

van de Weijer LL, Ercolano E, Zhang T, Shah M, Banton MC, Na J, et al. A novel patient-derived meningioma spheroid model as a tool to study and treat epithelial-to-mesenchymal transition (EMT) in meningiomas. Acta Neuropathol Commun. 2023;11(1):198.

Article  PubMed  PubMed Central  Google Scholar 

Pestinger V, Smith M, Sillo T, Findlay JM, Laes JF, Martin G, et al. Use of an integrated Pan-Cancer oncology enrichment Next-Generation sequencing assay to measure tumour mutational burden and detect clinically actionable variants. Mol Diagn Ther. 2020;24(3):339–49.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rogers MF, Shihab HA, Mort M, Cooper DN, Gaunt TR, Campbell C. FATHMM-XF: accurate prediction of pathogenic point mutations via extended features. Bioinformatics. 2018;34(3):511–3.

Article  CAS  PubMed  Google Scholar 

Strom SP. Current practices and guidelines for clinical next-generation sequencing oncology testing. Cancer Biol Med. 2016;13(1):3–11.

Article  PubMed  PubMed Central  Google Scholar 

Yan YH, Chen SX, Cheng LY, Rodriguez AY, Tang R, Cabrera K, et al. Confirming putative variants at ≤ 5% allele frequency using allele enrichment and Sanger sequencing. Sci Rep. 2021;11(1):11640.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Foulkes WD, Real FX. Many mosaic mutations. Curr Oncol. 2013;20(2):85–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Griffith M, Miller CA, Griffith OL, Krysiak K, Skidmore ZL, Ramu A, et al. Optimizing cancer genome sequencing and analysis. Cell Syst. 2015;1(3):210–23.

Article  CAS 

Comments (0)

No login
gif