Piepoli MF, Hoes AW, Agewall S, Albus C, Brotons C, Catapano AL et al. 2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts) Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR). Atherosclerosis. 2016;252:207– 74.

Larvin H, Kang J, Aggarwal VR, Pavitt S, Wu J. Risk of incident cardiovascular disease in people with periodontal disease: a systematic review and meta-analysis. Clin Experimental Dent Res. 2021;7(1):109–22.

Article  Google Scholar 

Virani SS, Alonso A, Benjamin EJ, Bittencourt MS, Callaway CW, Carson AP, et al. Heart disease and stroke statistics—2020 update: a report from the American heart association. Circulation. 2020;141(9):e139–596.

Article  PubMed  Google Scholar 

Collaborators GS. Global, regional, and National burden of stroke and its risk factors, 1990–2019: a systematic analysis for the global burden of disease study 2019. Lancet Neurol. 2021;20(10):795.

Article  Google Scholar 

Zhong S, Li L, Shen X, Li Q, Xu W, Wang X, et al. An update on lipid oxidation and inflammation in cardiovascular diseases. Free Radic Biol Med. 2019;144:266–78.

Article  CAS  PubMed  Google Scholar 

Rafieian-Kopaei M, Setorki M, Doudi M, Baradaran A, Nasri H. Atherosclerosis: process, indicators, risk factors and new hopes. Int J Prev Med. 2014;5(8):927.

PubMed  PubMed Central  Google Scholar 

Ference BA, Ginsberg HN, Graham I, Ray KK, Packard CJ, Bruckert E, et al. Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European atherosclerosis society consensus panel. Eur Heart J. 2017;38(32):2459–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang K, Qi X, Zhu F, Dong Q, Gou Z, Wang F, et al. Remnant cholesterol is associated with cardiovascular mortality. Front Cardiovasc Med. 2022;9:984711.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Han M, Huang K, Shen C, Hu H, Liu F, Li J, et al. Discordant high remnant cholesterol with LDL-C increases the risk of stroke: A Chinese prospective cohort study. Stroke. 2024;55(8):2066–74.

Article  CAS  PubMed  Google Scholar 

Yang XH, Zhang BL, Cheng Y, Fu SK, Jin HM. Association of remnant cholesterol with risk of cardiovascular disease events, stroke, and mortality: a systemic review and meta-analysis. Atherosclerosis. 2023;371:21–31.

Article  CAS  PubMed  Google Scholar 

De Lemos JA, Ayers CR, Levine BD, DeFilippi CR, Wang TJ, Hundley WG, et al. Multimodality strategy for cardiovascular risk assessment: performance in 2 population-based cohorts. Circulation. 2017;135(22):2119–32.

Article  PubMed  PubMed Central  Google Scholar 

Rizo-Téllez SA, Sekheri M, Filep JG. C-reactive protein: a target for therapy to reduce inflammation. Front Immunol. 2023;14:1237729.

Article  PubMed  PubMed Central  Google Scholar 

Bernelot Moens SJ, Verweij SL, Schnitzler JG, Stiekema LCA, Bos M, Langsted A, et al. Remnant cholesterol elicits arterial wall inflammation and a multilevel cellular immune response in humans. Arterioscler Thromb Vasc Biol. 2017;37(5):969–75.

Article  CAS  PubMed  Google Scholar 

Swastini DA, Wiryanthini IAD, Ariastuti NLP, Muliantara A. Atherosclerosis prediction with high sensitivity C-Reactive protein (hs-CRP) and related risk factor in patient with dyslipidemia. Open Access Maced J Med Sci. 2019;7(22):3887–90.

Article  PubMed  PubMed Central  Google Scholar 

Varbo A, Benn M, Tybjærg-Hansen A, Jørgensen AB, Frikke-Schmidt R, Nordestgaard BG. Remnant cholesterol as a causal risk factor for ischemic heart disease. J Am Coll Cardiol. 2013;61(4):427–36.

Article  CAS  PubMed  Google Scholar 

Libby P, Loscalzo J, Ridker PM, Farkouh ME, Hsue PY, Fuster V, et al. Inflammation, immunity, and infection in atherothrombosis: JACC review topic of the week. J Am Coll Cardiol. 2018;72(17):2071–81.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kardys I, de Maat MP, Uitterlinden AG, Hofman A, Witteman JC. C-reactive protein gene haplotypes and risk of coronary heart disease: the Rotterdam study. Eur Heart J. 2006;27(11):1331–7.

Article  CAS  PubMed  Google Scholar 

Chan DC, Kritharides L, Watts GF. The remnant-cholesterol/CRP nexus: trouble and strife when the fat hits the fire. Atherosclerosis. 2023;379:117169.

Article  PubMed  Google Scholar 

Doi T, Langsted A, Nordestgaard BG. Dual elevated remnant cholesterol and C-reactive protein in myocardial infarction, atherosclerotic cardiovascular disease, and mortality. Atherosclerosis. 2023;379:117141.

Article  CAS  PubMed  Google Scholar 

Chevli PA, Islam T, Pokharel Y, Rodriguez F, Virani SS, Blaha MJ, et al. Association between remnant lipoprotein cholesterol, high-sensitivity C-reactive protein, and risk of atherosclerotic cardiovascular disease events in the Multi-Ethnic study of atherosclerosis (MESA). J Clin Lipidol. 2022;16(6):870–7.

Article  PubMed  Google Scholar 

Ghayour-Mobarhan M, Moohebati M, Esmaily H, Ebrahimi M, Parizadeh SMR, Heidari-Bakavoli AR, et al. Mashhad stroke and heart atherosclerotic disorder (MASHAD) study: design, baseline characteristics and 10-year cardiovascular risk Estimation. Int J Public Health. 2015;60:561–72.

Article  PubMed  Google Scholar 

Tabatabaeizadeh S-A, Abdizadeh MF, Meshkat Z, Khodashenas E, Darroudi S, Fazeli M, et al. There is an association between serum high-sensitivity C-reactive protein (hs-CRP) concentrations and depression score in adolescent girls. Psychoneuroendocrinology. 2018;88:102–4.

Article  CAS  PubMed  Google Scholar 

Quispe R, Martin SS, Michos ED, Lamba I, Blumenthal RS, Saeed A, et al. Remnant cholesterol predicts cardiovascular disease beyond LDL and apob: a primary prevention study. Eur Heart J. 2021;42(42):4324–32.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kovacic S, Bakran M. Genetic susceptibility to atherosclerosis. Stroke Res Treat. 2012;2012(1):362941.

PubMed  PubMed Central  Google Scholar 

Marroquin OC, Kip KE, Kelley DE, Johnson BD, Shaw LJ, Bairey Merz CN, et al. Metabolic syndrome modifies the cardiovascular risk associated with angiographic coronary artery disease in women: a report from the women’s ischemia syndrome evaluation. Circulation. 2004;109(6):714–21.

Article  CAS  PubMed  Google Scholar 

Hatano S. Experience from a multicentre stroke register: a preliminary report. Bull World Health Organ. 1976;54(5):541.

CAS  PubMed  PubMed Central  Google Scholar 

Obsa MS, Ataro G, Awoke N, Jemal B, Tilahun T, Ayalew N, et al. Determinants of dyslipidemia in africa: a systematic review and meta-analysis. Front Cardiovasc Med. 2022;8:778891.

Article  PubMed  PubMed Central  Google Scholar 

Denegri A, Boriani G. High sensitivity C-reactive protein (hsCRP) and its implications in cardiovascular outcomes. Curr Pharm Design. 2021;27(2):263–75.

Article  CAS  Google Scholar 

Banait T, Wanjari A, Danade V, Banait S, Jain J. Role of High-Sensitivity C-reactive protein (Hs-CRP) in Non-communicable diseases: A review. Cureus. 2022;14(10):e30225.

PubMed  PubMed Central  Google Scholar 

Kandelouei T, Abbasifard M, Imani D, Aslani S, Razi B, Fasihi M, et al. Effect of Statins on serum level of hs-CRP and CRP in patients with cardiovascular diseases: A systematic review and Meta-Analysis of randomized controlled trials. Mediators Inflamm. 2022;2022:8732360.

Article  PubMed  PubMed Central  Google Scholar 

Yeh ET. High-sensitivity C‐reactive protein as a risk assessment tool for cardiovascular disease. Clinical cardiology: an international indexed and Peer‐Reviewed. J Adv Treat Cardiovasc Disease. 2005;28(9):408–12.

Google Scholar 

Ridker PM. High-sensitivity C-reactive protein and cardiovascular risk: rationale for screening and primary prevention. Am J Cardiol. 2003;92(4):17–22.

Article  Google Scholar 

Arnett DK, Blumenthal RS, Albert MA, Buroker AB, Goldberger ZD, Hahn EJ, et al. 2019 ACC/AHA guideline on the primary prevention of cardiovascular disease: A report of the American college of cardiology/american heart association task force on clinical practice guidelines. Circulation. 2019;140(11):e596–646.