Dent R, Trudeau M, Pritchard KI, Hanna WM, Kahn HK, Sawka CA et al (2007) Triple-negative breast cancer: clinical features and patterns of recurrence. Clin Cancer Res 13(15):4429–4434
Kassam F, Enright K, Dent R, Dranitsaris G, Myers J, Flynn C et al (2009) Survival outcomes for patients with metastatic triple-negative breast cancer: implications for clinical practice and trial design. Clin Breast Cancer 9(1):29–33
Javle M, Curtin NJ (2011) The potential for poly (ADP-ribose) polymerase inhibitors in cancer therapy. Therapeutic Adv Med Oncol 3(6):257–267
Juarez-Salinas H, Sims JL, Jacobson MK (1979) Poly(ADP-ribose) levels in carcinogen-treated cells. Nature 282(5740):740–741
Article CAS PubMed Google Scholar
Robson M, Im S-A, Senkus E, Xu B, Domchek SM, Masuda N et al (2017) Olaparib for metastatic breast cancer in patients with a germline <i>BRCA</i> mutation. N Engl J Med 377(6):523–533
Article CAS PubMed Google Scholar
Litton JK, Rugo HS, Ettl J, Hurvitz SA, Gonçalves A, Lee K-H et al (2018) Talazoparib in patients with advanced breast cancer and a germline <i>BRCA</i> mutation. N Engl J Med 379(8):753–763
Article CAS PubMed PubMed Central Google Scholar
Rodon J, Dienstmann R, Serra V, Tabernero J (2013) Development of PI3K inhibitors: lessons learned from early clinical trials. Nat Rev Clin Oncol 10(3):143–153
Article CAS PubMed Google Scholar
Koboldt DC, Fulton RS, McLellan MD, Schmidt H, Kalicki-Veizer J, McMichael JF et al (2012) Comprehensive molecular portraits of human breast tumours. Nature 490(7418):61–70
Kumar A, Fernandez-Capetillo O, Carrera AC (2010) Nuclear phosphoinositide 3-kinase beta controls double-strand break DNA repair. Proc Natl Acad Sci U S A 107(16):7491–7496
Article CAS PubMed PubMed Central Google Scholar
Toulany M, Lee KJ, Fattah KR, Lin YF, Fehrenbacher B, Schaller M et al (2012) Akt promotes post-irradiation survival of human tumor cells through initiation, progression, and termination of DNA-PKcs-dependent DNA double-strand break repair. Mol Cancer Res 10(7):945–957
Article CAS PubMed Google Scholar
Ibrahim YH, García-García C, Serra V, He L, Torres-Lockhart K, Prat A et al (2012) PI3K inhibition impairs BRCA1/2 expression and sensitizes BRCA-proficient triple-negative breast cancer to PARP inhibition. Cancer Discov 2(11):1036–1047
Article CAS PubMed PubMed Central Google Scholar
Juvekar A, Burga LN, Hu H, Lunsford EP, Ibrahim YH, Balmañà J et al (2012) Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer. Cancer Discov 2(11):1048–1063
Article CAS PubMed PubMed Central Google Scholar
Hu H, Juvekar A, Lyssiotis CA, Lien EC, Albeck JG, Oh D et al (2016) Phosphoinositide 3-kinase regulates glycolysis through mobilization of aldolase from the actin cytoskeleton. Cell 164(3):433–446
Article CAS PubMed PubMed Central Google Scholar
Matulonis UA, Wulf GM, Barry WT, Birrer M, Westin SN, Farooq S et al (2017) Phase I dose escalation study of the PI3kinase pathway inhibitor BKM120 and the oral poly (ADP ribose) polymerase (PARP) inhibitor olaparib for the treatment of high-grade serous ovarian and breast cancer. Ann Oncol 28(3):512–518
Article CAS PubMed Google Scholar
Konstantinopoulos PA, Barry WT, Birrer M, Westin SN, Cadoo KA, Shapiro GI et al (2019) Olaparib and & #x3b1;-specific PI3K inhibitor alpelisib for patients with epithelial ovarian cancer: a dose-escalation and dose-expansion phase 1b trial. Lancet Oncol 20(4):570–580
Article CAS PubMed PubMed Central Google Scholar
Lord CJ, Ashworth A (2016) BRCAness revisited. Nat Rev Cancer 16(2):110–120
Article CAS PubMed Google Scholar
Tung NM, Robson ME, Nanda R, Li T, Vinayak S, Shah PD et al (2024) TBCRC 048 (olaparib expanded) expansion cohorts: phase 2 study of olaparib monotherapy in patients (pts) with metastatic breast cancer (MBC) with germline (g) mutations in PALB2 or somatic (s) mutations in BRCA1 or BRCA2. J Clin Oncol 42(16):1021
Telli ML, Timms KM, Reid J, Hennessy B, Mills GB, Jensen KC et al (2016) Homologous recombination deficiency (hrd) score predicts response to platinum-containing neoadjuvant chemotherapy in patients with triple-negative breast cancer. Clin Cancer Res 22(15):3764–3773
Article CAS PubMed PubMed Central Google Scholar
Von Minckwitz GTK, Untch M et al (2015) Prediction of pathological complete response (pCR) by homologous recombination deficiency (HRD) after carboplatin-containing neoadjuvant chemotherapy in patients with TNBC: results from GeparSixto. Annual meeting of the American Society of Clinical Oncology. J Clin Oncol. https://doi.org/10.1200/jco.2015.33.15_suppl.1004
Connolly R, Elkin E, Timms K, Goetz M, Boughey J, Zhang Z, Walsh B, Carpenter J, Storniolo A, Watkins S, Gabrielson E (2016) Abstract P3–07-13: homologous recombination deficiency (HRD) as a predictive biomarker of response to preoperative systemic therapy (PST) in TBCRC008 comprising a platinum in HER2-negative primary operable breast cancer. Cancer Res 76(4_ Supplement):P3-07
How JA, Jazaeri AA, Fellman B, Daniels MS, Penn S, Solimeno C, Yuan Y, Schmeler K, Lanchbury JS, Timms K, Lu KH (2021) Modification of homologous recombination deficiency score threshold and association with long-term survival in epithelial ovarian cancer. Cancers 13(5):946
Article CAS PubMed PubMed Central Google Scholar
Telli ML, Metzger O, Timms K, Evans B, Vogel D, Wei H et al (2018) Evaluation of homologous recombination deficiency (HRD) status with pathological response to carboplatin +/- veliparib in BrighTNess, a randomized phase 3 study in early stage TNBC. J Clin Oncol 36(15_Suppl):519
Layman R, Wesolowski R, Han H, Specht JM, Stringer-Reasor EM, Dees EC, Kabos P, Mayer IA, Vaishampayan U, Lu J, Gogineni K (2022) Abstract PD13-02: phase Ib expansion study of gedatolisib in combination with palbociclib and endocrine therapy in women with ER+ metastatic breast cancer. Cancer Res 82(4_Supplement):PD13–PD22
Baselga J, Campone M, Piccart M, Burris HA, Rugo HS, Sahmoud T et al (2012) Everolimus in postmenopausal hormone-receptor–positive advanced breast cancer. N Engl J Med 366(6):520–529
Article CAS PubMed Google Scholar
Kornblum N, Zhao F, Manola J, Klein P, Ramaswamy B, Brufsky A et al (2018) Randomized phase II trial of fulvestrant plus everolimus or placebo in postmenopausal women with hormone receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer resistant to aromatase inhibitor therapy: results of PrE0102. J Clin Oncol 36(16):1556–1563
Article CAS PubMed PubMed Central Google Scholar
Esposito A, Viale G, Curigliano G (2019) Safety, tolerability, and management of toxic effects of phosphatidylinositol 3-kinase inhibitor treatment in patients with cancer: a review. JAMA Oncol 5(9):1347–1354
André F, Ciruelos E, Rubovszky G, Campone M, Loibl S, Rugo Hope S et al (2019) Alpelisib for PIK3CA-mutated, hormone receptor-positive advanced breast cancer. N Engl J Med 380(20):1929–1940
Lee C-Y, Cheng W-F, Lin P-H, Chen Y-L, Huang S-H, Lei K-H et al (2023) An activity-based functional test for identifying homologous recombination deficiencies across cancer types in real time. Cell Rep Med 4(11):101247
Article CAS PubMed PubMed Central Google Scholar
Slootbeek PH, Kloots IS, van Oort IM, Kroeze LI, Schalken JA, Bloemendal HJ, Mehra N (2023) Cross-resistance between platinum-based chemotherapy and PARP inhibitors in castration-resistant prostate cancer. Cancers 15(10):2814
Article CAS PubMed PubMed Central Google Scholar
McMullen M, Karakasis K, Madariaga A, Oza AM (2020) Overcoming platinum and PARP-inhibitor resistance in ovarian cancer. Cancers 12(6):1607
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