Van Baelen K, Geukens T, Maetens M, Tjan-Heijnen V, Lord CJ, Linn S, et al. Current and future diagnostic and treatment strategies for patients with invasive lobular breast cancer. Ann Oncol. 2022;33:769–85.

Article  PubMed  Google Scholar 

Oesterreich S, Nasrazadani A, Zou J, Carleton N, Onger T, Wright MD, et al. Clinicopathological features and outcomes comparing patients with invasive ductal and lobular breast Cancer. J Natl Cancer Inst. 2022;114:1511–22.

Article  PubMed  PubMed Central  Google Scholar 

Timbres J, Moss C, Mera A, Haire A, Gillett C, Van Hemelrijck M et al. Survival outcomes in invasive lobular carcinoma compared to oestrogen Receptor-Positive invasive ductal carcinoma. Cancers (Basel) 2021; 13.

Ciriello G, Gatza ML, Beck AH, Wilkerson MD, Rhie SK, Pastore A, et al. Compr Mol Portraits Invasive Lobular Breast Cancer Cell. 2015;163:506–19.

Desmedt C, Zoppoli G, Gundem G, Pruneri G, Larsimont D, Fornili M, et al. Genomic characterization of primary invasive lobular breast Cancer. J Clin Oncol. 2016;34:1872–81.

Article  CAS  PubMed  Google Scholar 

Michaut M, Chin SF, Majewski I, Severson TM, Bismeijer T, de Koning L, et al. Integration of genomic, transcriptomic and proteomic data identifies two biologically distinct subtypes of invasive lobular breast cancer. Sci Rep. 2016;6:18517.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pereira B, Chin SF, Rueda OM, Vollan HK, Provenzano E, Bardwell HA, et al. The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes. Nat Commun. 2016;7:11479.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Houthuijzen JM, Jonkers J. Cancer-associated fibroblasts as key regulators of the breast cancer tumor microenvironment. Cancer Metastasis Rev. 2018;37:577–97.

Article  CAS  PubMed  Google Scholar 

Kalluri R. The biology and function of fibroblasts in cancer. Nat Rev Cancer. 2016;16:582–98.

Article  CAS  PubMed  Google Scholar 

Burke K, Tang P, Brown E. Second harmonic generation reveals matrix alterations during breast tumor progression. J Biomed Opt. 2013;18:31106.

Article  PubMed  Google Scholar 

Natal RA, Paiva GR, Pelegati VB, Marenco L, Alvarenga CA, Vargas RF, et al. Exploring collagen parameters in pure special types of invasive breast Cancer. Sci Rep. 2019;9:7715.

Article  PubMed  PubMed Central  Google Scholar 

Nakagawa S, Miki Y, Miyashita M, Hata S, Takahashi Y, Rai Y, et al. Tumor microenvironment in invasive lobular carcinoma: possible therapeutic targets. Breast Cancer Res Treat. 2016;155:65–75.

Article  CAS  PubMed  Google Scholar 

Houthuijzen JM, de Bruijn R, van der Burg E, Drenth AP, Wientjens E, Filipovic T, et al. CD26-negative and CD26-positive tissue-resident fibroblasts contribute to functionally distinct CAF subpopulations in breast cancer. Nat Commun. 2023;14:183.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Park CK, Jung WH, Koo JS. Expression of cancer-associated fibroblast-related proteins differs between invasive lobular carcinoma and invasive ductal carcinoma. Breast Cancer Res Treat. 2016;159:55–69.

Article  CAS  PubMed  Google Scholar 

Westhoff CC, Jank P, Jacke CO, Albert US, Ebrahimsade S, Barth PJ, et al. Prognostic relevance of the loss of stromal CD34 positive fibroblasts in invasive lobular carcinoma of the breast. Virchows Arch. 2020;477:717–24.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Batra H, Ding Q, Pandurengan R, Ibarguen H, Rabassedas NB, Sahin A, et al. Exploration of cancer associated fibroblasts phenotypes in the tumor microenvironment of classical and pleomorphic invasive lobular carcinoma. Front Oncol. 2023;13:1281650.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gomez-Cuadrado L, Bullock E, Mabruk Z, Zhao H, Souleimanova M, Noer PR et al. Characterisation of the stromal microenvironment in lobular breast Cancer. Cancers (Basel) 2022; 14.

Ichiba M, Nakajima K, Yamanaka Y, Kiuchi N, Hirano T. Autoregulation of the Stat3 gene through Cooperation with a cAMP-responsive element-binding protein. J Biol Chem. 1998;273:6132–8.

Article  CAS  PubMed  Google Scholar 

Elangovan A, Hooda J, Savariau L, Puthanmadhomnarayanan S, Yates ME, Chen J, et al. Loss of E-cadherin induces IGF1R activation and reveals a targetable pathway in invasive lobular breast carcinoma. Mol Cancer Res. 2022;20:1405–19.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Teo K, Gomez-Cuadrado L, Tenhagen M, Byron A, Ratze M, van Amersfoort M, et al. E-cadherin loss induces targetable autocrine activation of growth factor signalling in lobular breast cancer. Sci Rep. 2018;8:15454.

Article  PubMed  PubMed Central  Google Scholar 

Johnson DE, O’Keefe RA, Grandis JR. Targeting the IL-6/JAK/STAT3 signalling axis in cancer. Nat Rev Clin Oncol. 2018;15:234–48.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guillen KP, Fujita M, Butterfield AJ, Scherer SD, Bailey MH, Chu Z, et al. A human breast cancer-derived xenograft and organoid platform for drug discovery and precision oncology. Nat Cancer. 2022;3:232–50.

Article  PubMed  PubMed Central  Google Scholar 

Wu SZ, Al-Eryani G, Roden DL, Junankar S, Harvey K, Andersson A, et al. A single-cell and spatially resolved atlas of human breast cancers. Nat Genet. 2021;53:1334–47.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cancer Genome Atlas N. Comprehensive molecular portraits of human breast tumours. Nature. 2012;490:61–70.

Article  Google Scholar 

Yoshihara K, Shahmoradgoli M, Martinez E, Vegesna R, Kim H, Torres-Garcia W, et al. Inferring tumour purity and stromal and immune cell admixture from expression data. Nat Commun. 2013;4:2612.

Article  PubMed  Google Scholar 

Finak G, Bertos N, Pepin F, Sadekova S, Souleimanova M, Zhao H, et al. Stromal gene expression predicts clinical outcome in breast cancer. Nat Med. 2008;14:518–27.

Article  CAS  PubMed  Google Scholar 

Morrow E, Pennel K, Hatthakarnkul P, Leslie H, Mallon E, Andersen D, et al. High expression of STAT3 within the tumour-associated stroma predicts poor outcome in breast cancer patients. Cancer Med. 2023;12:13225–40.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gujam FJ, McMillan DC, Edwards J. The relationship between total and phosphorylated STAT1 and STAT3 tumour cell expression, components of tumour microenvironment and survival in patients with invasive ductal breast cancer. Oncotarget. 2016;7:77607–21.

Article  PubMed  PubMed Central  Google Scholar 

Siersbaek R, Scabia V, Nagarajan S, Chernukhin I, Papachristou EK, Broome R, et al. IL6/STAT3 signaling hijacks Estrogen receptor alpha enhancers to drive breast Cancer metastasis. Cancer Cell. 2020;38:412–e423419.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liberzon A, Birger C, Thorvaldsdottir H, Ghandi M, Mesirov JP, Tamayo P. The molecular signatures database (MSigDB) hallmark gene set collection. Cell Syst. 2015;1:417–25.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA et al. Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proceedings of the National Academy of Sciences. 2005;102:15545–15550.

Avalle L, Marino F, Camporeale A, Guglielmi C, Viavattene D, Bandini S, et al. Liver-Specific siRNA-Mediated Stat3 or C3 knockdown improves the outcome of experimental autoimmune myocarditis. Mol Ther Methods Clin Dev. 2020;18:62–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Richard E, Grellety T, Velasco V, MacGrogan G, Bonnefoi H, Iggo R. The mammary ducts create a favourable microenvironment for xenografting of luminal and molecular apocrine breast tumours. J Pathol. 2016;240:256–61.

Article