Impact of sodium bicarbonate locking solution on catheter-related blood stream infection in hemodialysis patients: comparative effectiveness of three locks

Yoshino M, Kuhlmann MK, Kotanko P, Greenwood RN, Pisoni RL, Port FK, Jager KJ, Homel P, Augustijn H, de Charro FT, Collart F, Erek E, Finne P, Garcia-Garcia G, Grönhagen-Riska C, Ioannidis GA, Ivis F, Leivestad T, Løkkegaard H, Lopot F, Jin DC, Kramar R, Nakao T, Nandakumar M, Ramirez S, van der Sande FM, Schön S, Simpson K, Walker RG, Zaluska W, Levin NW (2006) International differences in dialysis mortality reflect background general population atherosclerotic cardiovascular mortality. J Am Soc Nephrol 17(12):3510–3519. https://doi.org/10.1681/ASN.2006020156. (Epub 2006 Nov 15 PMID: 17108318)

Article  PubMed  Google Scholar 

Allon M (2007) Current management of vascular access. Clin J Am Soc Nephrol 2(4):786–800. https://doi.org/10.2215/CJN.00860207. (Epub 2007 May 30 PMID: 17699495)

Article  PubMed  Google Scholar 

Niyyar VD, Chan MR (2013) Interventional nephrology: catheter dysfunction–prevention and troubleshooting. Clin J Am Soc Nephrol 8(7):1234–1243. https://doi.org/10.2215/CJN.00960113. (PMID: 23824200)

Article  PubMed  Google Scholar 

Ravani P, Palmer SC, Oliver MJ, Quinn RR, MacRae JM, Tai DJ, Pannu NI, Thomas C, Hemmelgarn BR, Craig JC, Manns B, Tonelli M, Strippoli GF (2013) James MT 2013 associations between hemodialysis access type and clinical outcomes: a systematic review. J Am Soc Nephrol. 3:465–73. https://doi.org/10.1681/ASN.2012070643

Article  Google Scholar 

Oliver MJ, Callery SM, Thorpe KE, Schwab SJ, Churchill DN (2000) Risk of bacteremia from temporary hemodialysis catheters by site of insertion and duration of use: a prospective study. Kidney Int 58(6):2543–2545. https://doi.org/10.1046/j.1523-1755.2000.00439.x. (PMID: 11115089)

Article  CAS  PubMed  Google Scholar 

Miller LM, Clark E, Dipchand C, Hiremath S, Kappel J, Kiaii M, Canadian Society of Nephrology Vascular Access Work Group et al (2016) Hemodialysis tunneled catheter-related infections. Can J Kidney Health Dis. https://doi.org/10.1177/2054358116669129

Article  PubMed  PubMed Central  Google Scholar 

Fisher M, Golestaneh L, Allon M, Abreo K, Mokrzycki MH (2020) Prevention of bloodstream infections in patients undergoing hemodialysis. Clin J Am Soc Nephrol. 15(1):132–151. https://doi.org/10.2215/CJN.06820619

Article  CAS  PubMed  Google Scholar 

Almeida BM, Moreno DH, Vasconcelos V, Cacione DG (2022) Interventions for treating catheter-related bloodstream infections in people receiving maintenance haemodialysis. Cochrane Database Syst Rev 4:CD013554. https://doi.org/10.1002/14651858.CD013554

Article  PubMed  Google Scholar 

Arechabala MC, Catoni MI, Claro JC, Rojas NP, Rubio ME, Calvo MA, Letelier LM (2018) Antimicrobial lock solutions for preventing catheter-related infections in haemodialysis. Cochrane Database Syst Rev 4(4):CD010597. https://doi.org/10.1002/14651858.CD010597.pub2

Article  PubMed  Google Scholar 

Abdul Salim S, Masoud AT, Thongprayoon C, Cheungpasitporn W, Soliman KM, Garla V, Sofy AA, Ahmed AS, Abdelsattar AT, Zsom L, Tapolyai M, Fülöp T (2021) Systematic review and meta-analysis of antibiotic and antimicrobial lock solutions for prevention of hemodialysis catheter-related infections. ASAIO J 67(10):1079–1086. https://doi.org/10.1097/MAT.0000000000001382. (PMID: 33587469)

Article  PubMed  Google Scholar 

Tchokhonelidze I (2023) Global dialysis perspective: georgia. Kidney360 4(1):106–109. https://doi.org/10.3467/KID.0000772022

Article  PubMed  Google Scholar 

Dialysis Nephrology and Kidney Transplantation Union of Georgia. Available at: https://dntunion.ge/en/ (Accessed 29. March 2024).

El-Hennawy AS, Frolova E, Pollack E (2017) First time sodium bicarbonate catheter lock solution is found to be a safe and effective lock method in preventing hemodialysis catheter loss due to lumen clot formation. J Clin Nephrol Res 4:1078–1082

Google Scholar 

El-Hennawy AS, Frolova E, Romney WA (2019) Sodium bicarbonate catheter lock solution reduces hemodialysis catheter loss due to catheter-related thrombosis and bloodstream infection: an open-label clinical trial. Nephrol Dial Transplant 34(10):1739–1745. https://doi.org/10.1093/ndt/gfy388

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wong DW, Mishkin FS, Tanaka TT (1980) The effects of bicarbonate on blood coagulation. JAMA 244(1):61–62 (PMID: 7382058)

Article  CAS  PubMed  Google Scholar 

Farha MA, French S, Stokes JM, Brown ED (2018) Bicarbonate alters bacterial susceptibility to antibiotics by targeting the proton motive force. ACS Infect Dis 4(3):382–390. https://doi.org/10.1021/acsinfecdis.7b00194. (Epub 2018 Jan 4 PMID: 29264917)

Article  CAS  PubMed  Google Scholar 

Centers for Disease Control and Prevention:Dialysis Safety Core Interventions, 2016. Available at: https://www.cdc.gov/dialysis/ prevention-tools/core-interventions.html. Accessed January 3, 2022

Lacson E Jr, Wang W, Lazarus JM, Hakim RM (2010) Change in vascular access and hospitalization risk in long-term hemodialysis patients. Clin J Am Soc Nephrol 5(11):1996–2003. https://doi.org/10.2215/CJN.08961209

Article  PubMed  PubMed Central  Google Scholar 

Krishnasami Z, Carlton D, Bimbo L, Taylor ME, Balkovetz DF, Barker J et al (2002) Management of hemodialysis catheter-related bacteremia with an adjunctive antibiotic lock solution. Kidney Int 61(3):1136–1142. https://doi.org/10.1046/j.1523-1755.2002.00201.x

Article  PubMed  Google Scholar 

Landry DL, Braden GL, Gobeille SL, Haessler SD, Vaidya CK, Sweet SJ (2010) Emergence of gentamicin-resistant bacteremia in hemodialysis patients receiving gentamicin lock catheter prophylaxis. Clin J Am Soc Nephrol 5(10):1799–1804. https://doi.org/10.2215/CJN.01270210

Article  PubMed  PubMed Central  Google Scholar 

US Food and Drug Administration. Warning on Tricitrasol Dialysis; Catheter Anticoagulant. FDATalk paper (Apr) 16, 14April 2000

Polaschegg HD, Sodemann K (2003) Risks related to catheter locking solutions containing concentrated citrate. Nephrol Dial Transplant 18(12):2688–2690. https://doi.org/10.1093/ndt/gfg481. (PMID: 14605312)

Article  PubMed  Google Scholar 

Moran J, Sun S, Khababa I, Pedan A, Doss S, Schiller B (2012) A randomized trial comparing gentamicin/citrate and heparin locks for central venous catheters in maintenance hemodialysis patients. Am J Kidney Dis 59:102–107

Article  CAS  PubMed  Google Scholar 

Moore CL, Besarab A, Ajluni M, Soi V, Peterson EL, Johnson LE et al (2014) Comparative effectiveness of two catheter locking solutions to reduce catheter-related bloodstream infection in hemodialysis patients. Clin J Am Soc Nephrol 9:1232–1239

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lok CE, Huber TS, Lee T, Shenoy S, Yevzlin AS, Abreo K, National Kidney Foundation et al (2020) KDOQI clinical practice guideline for vascular access: 2019 update. Am J Kidney Dis. https://doi.org/10.1053/j.ajkd.2019.12.001

Article  PubMed  Google Scholar 

Islam M (2024) Sodium bicarbonate is a potential alternative to classic heparin as a lock solution for non-tunneled dialysis catheters: a result from the prospective randomized BicarbLock trial. Int Urol Nephrol 56(4):1465–1474. https://doi.org/10.1007/s11255-023-03821-9. (Epub 2023 Oct 12 PMID: 37823971)

Article  CAS  PubMed  Google Scholar 

Parikh S, Nijmeh R, Van Cleef S, Timmerman S, Bhatt UY, Agarwal AK (2012) Catheter outcomes in the short-term inpatient setting: a controlled quality improvement study comparing citrate and heparin lock. Semin Dial 25(3):351–356. https://doi.org/10.1111/j.1525-139X.2011.00966.x. (Epub 2011 Nov 10 PMID: 22074231)

Article  PubMed  Google Scholar 

Davenport A, Tolwani A (2009) Citrate anticoagulation for continuous renal replacement therapy (CRRT) in patients with acute kidney injury admitted to the intensive care unit. NDT Plus 6:439–47. https://doi.org/10.1093/ndtplus/sfp136

Article  CAS  Google Scholar 

Wathanavasin W, Phannajit J, Poosoonthornsri M, Lewsuwan S, Tanateerapong P, Chongthanakorn K, Takkavatakarn K, Katavetin P, Tiranathanagul K, Eiam-Ong S, Susantitaphong P (2021) A randomized controlled trial of comparative efficacy between sodium bicarbonate and heparin as a locking solution for tunneled central venous catheters among patients requiring maintenance hemodialysis. Can J Kidney Health Dis 30(8):20543581211046076. https://doi.org/10.1177/20543581211046077.PMID:34616559;PMCID:PMC8488503

Article  Google Scholar 

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