Drumm MR et al (2020) Extensive brainstem infiltration, not mass effect, is a common feature of end-stage cerebral glioblastomas, Neuro Oncol, vol. 22, pp. 470–479, Apr. https://doi.org/10.1093/neuonc/noz216

Ostrom QT et al (2023) National-level overall survival patterns for molecularly-defined diffuse glioma types in the United States, Neuro Oncol, vol. 25, pp. 799–807, Apr. https://doi.org/10.1093/neuonc/noac198

Wick W, Osswald M, Wick A, Winkler F (2018) Treatment of glioblastoma in adults, Jan. SAGE Publications Ltd. https://doi.org/10.1177/1756286418790452

Stupp R, Brada M, van den Bent MJ, Tonn JC, Pentheroudakis G (Sep. 2014) High-grade glioma: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 25:93–101. https://doi.org/10.1093/annonc/mdu050

Wilczyński B, Dąbrowska A, Kulbacka J, Baczyńska D (2024) Chemoresistance and the tumor microenvironment: the critical role of cell-cell communication. Dec. https://doi.org/10.1186/s12964-024-01857-7

Article  Google Scholar 

Quail DF, Joyce JA (2013) Microenvironmental regulation of tumor progression and metastasis. Nov. https://doi.org/10.1038/nm.3394

Article  Google Scholar 

Venkataramani V et al (Sep. 2019) Glutamatergic synaptic input to glioma cells drives brain tumour progression. Nature 573:532–538. https://doi.org/10.1038/s41586-019-1564-x

Formicola B et al (2019) Differential exchange of multifunctional liposomes between glioblastoma cells and healthy astrocytes via tunneling nanotubes. Front Bioeng Biotechnol 7:403. https://doi.org/10.3389/fbioe.2019.00403

Article  PubMed  PubMed Central  Google Scholar 

Weil S et al (Oct. 2017) Tumor microtubes convey resistance to surgical lesions and chemotherapy in gliomas. Neuro Oncol 19:1316–1326. https://doi.org/10.1093/neuonc/nox070

Osswald M et al (2015) Brain tumour cells interconnect to a functional and resistant network, Nature, vol. 528, pp. 93–98, Dec. https://doi.org/10.1038/nature16071

Sharma P, Aaroe A, Liang J, Puduvalli VK (2023) Tumor microenvironment in glioblastoma: current and emerging concepts. Neurooncol Adv 5:vdad009. https://doi.org/10.1093/noajnl/vdad009

Article  PubMed  PubMed Central  Google Scholar 

Gerdes HH, Bukoreshtliev NV, Barroso JFV (May 2007) Tunneling nanotubes: A new route for the exchange of components between animal cells. Elsevier. https://doi.org/10.1016/j.febslet.2007.03.071

Valdebenito S, Audia A, Bhat KPL, Okafo G, Eugenin EA (Sep. 2020) Tunneling nanotubes mediate adaptation of glioblastoma cells to Temozolomide and ionizing radiation treatment. iScience 23:101450. https://doi.org/10.1016/j.isci.2020.101450

Valdebenito S et al (Dec. 2021) Tunneling nanotubes, TNT, communicate glioblastoma with surrounding non-tumor astrocytes to adapt them to hypoxic and metabolic tumor conditions. Sci Rep 11. https://doi.org/10.1038/s41598-021-93775-8

Demircan T, Yavuz M, Kaya E, Akgül S, Altuntaş E (2021) Cellular and molecular comparison of glioblastoma multiform cell lines. Cureus Jun. https://doi.org/10.7759/cureus.16043

Article  Google Scholar 

Fathima Hurmath K, Ramaswamy P, Nandakumar DN (2014) IL-1β microenvironment promotes proliferation, migration and invasion of human glioma cells, Cell Biol Int, vol. 38, pp. 1415–1422, Dec. https://doi.org/10.1002/cbin.10353

Saha T et al (Jan. 2022) Intercellular nanotubes mediate mitochondrial trafficking between cancer and immune cells. Nat Nanotechnol 17:98–106. https://doi.org/10.1038/s41565-021-01000-4

Dalavaikodihalli Nanjaiah N, Ramaswamy P, Goswami K, Fathima H K, and, Borkotokey M (2019) Survival of glioblastoma cells in response to endogenous and exogenous oxidative challenges: possible implication of NMDA receptor-mediated regulation of redox homeostasis, Cell Biol Int, vol. 43, pp. 1443–1452, Dec. https://doi.org/10.1002/cbin.11193

Rustom A, Saffrich R, Markovic I, Walther P, Gerdes HH (1979) Nanotubular Highways for Intercellular Organelle Transport, Science vol. 303, pp. 1007–1010, Feb. 2004. https://doi.org/10.1126/science.1093133

Kolba MD et al (Nov. 2019) Tunneling nanotube-mediated intercellular vesicle and protein transfer in the stroma-provided Imatinib resistance in chronic myeloid leukemia cells. Cell Death Dis 10. https://doi.org/10.1038/s41419-019-2045-8

Spees JL, Olson SD, Whitney MJ, Prockop DJ (2006) Mitochondrial transfer between cells can rescue aerobic respiration, Proc Natl Acad Sci U S A, vol. 103, pp. 1283–1288, Jan. https://doi.org/10.1073/pnas.0510511103

Zhang H et al (Oct. 2023) Systematic investigation of mitochondrial transfer between cancer cells and T cells at single-cell resolution. Cancer Cell 41:1788–1802. https://doi.org/10.1016/j.ccell.2023.09.003..e10

Pinto G et al (2021) Patient-derived glioblastoma stem cells transfer mitochondria through tunneling nanotubes in tumor organoids, Biochemical Journal, vol. 478, pp. 21–39, Jan. https://doi.org/10.1042/BCJ20200710

Hoover G et al (2025) Nerve-to-cancer transfer of mitochondria during cancer metastasis. Nature. https://doi.org/10.1038/s41586-025-09176-8

Article  PubMed  Google Scholar 

Ikeda H et al (2025) Immune evasion through mitochondrial transfer in the tumour microenvironment. Nat Jan. https://doi.org/10.1038/s41586-024-08439-0

Article  Google Scholar 

Tishchenko A et al (2020) Cx43 and associated cell signaling pathways regulate tunneling nanotubes in breast cancer cells, Cancers (Basel), vol. 12, pp. 1–25, Oct. https://doi.org/10.3390/cancers12102798

Pridham KJ et al (2022) Connexin 43 confers chemoresistance through activating PI3K, Oncogenesis, vol. 11, Dec. https://doi.org/10.1038/s41389-022-00378-7

Crespo S, Kind M, Arcaro A (Mar. 2016) The role of the PI3K/AKT/mTOR pathway in brain tumor metastasis. J Cancer Metastasis Treat 2:80. https://doi.org/10.20517/2394-4722.2015.72

Kameritsch P, Pogoda K, Pohl U (2012) Channel-independent influence of connexin 43 on cell migration. Aug. https://doi.org/10.1016/j.bbamem.2011.11.016

Article  Google Scholar 

Ravi VM et al (Dec. 2022) T-cell dysfunction in the glioblastoma microenvironment is mediated by myeloid cells releasing interleukin-10. Nat Commun 13. https://doi.org/10.1038/s41467-022-28523-1

Agnihotri S, Zadeh G (Feb. 2016) Metabolic reprogramming in glioblastoma: the influence of cancer metabolism on epigenetics and unanswered questions. Neuro Oncol 18:160–172. https://doi.org/10.1093/neuonc/nov125

Kamarajugadda S et al (May 2012) Glucose oxidation modulates Anoikis and tumor metastasis. Mol Cell Biol 32:1893–1907. https://doi.org/10.1128/mcb.06248-11

Kowaltowski AJ, de Souza-Pinto NC, Castilho RF, Vercesi AE (2009) Mitochondria and reactive oxygen species. Aug. https://doi.org/10.1016/j.freeradbiomed.2009.05.004

Article  Google Scholar 

Mattiazzi M et al (2004) The mtDNA T8993G (NARP) mutation results in an impairment of oxidative phosphorylation that can be improved by antioxidants, Hum Mol Genet, vol. 13, pp. 869–879, Apr. https://doi.org/10.1093/hmg/ddh103

Kuznetsov AV, Margreiter R, Ausserlechner MJ, Hagenbuchner J (2022) The Complex Interplay between Mitochondria, ROS and Entire Cellular Metabolism., Antioxidants (Basel), vol. 11, Oct. https://doi.org/10.3390/antiox11101995

Yusri K, Jose S, Vermeulen KS, Tan TCM, Sorrentino V (Jun. 2025) The role of NAD + metabolism and its modulation of mitochondria in aging and disease. Npj Metabolic Health Disease 3:26. https://doi.org/10.1038/s44324-025-00067-0

Ouyang Y et al (Jan. 2024) Phosphate starvation signaling increases mitochondrial membrane potential through respiration-independent mechanisms. Elife 13. https://doi.org/10.7554/eLife.84282

van Hameren G et al (Jun. 2019) In vivo real-time dynamics of ATP and ROS production in axonal mitochondria show decoupling in mouse models of peripheral neuropathies. Acta Neuropathol Commun 7:86. https://doi.org/10.1186/s40478-019-0740-4

Skulachev VP (1998) Uncoupling: new approaches to an old problem of bioenergetics. Feb. https://doi.org/10.1016/S0005-2728(97)00091-1

Article  Google Scholar 

Brand MD (2000) Uncoupling to survive? The role of mitochondrial inefficiency in ageing. Experimental Gerontol 811–820. https://doi.org/10.1016/S0531-5565(00)00135-2

Caldeira Da Silva CC, Cerqueira FM, Barbosa LF, Medeiros MHG, Kowaltowski AJ (2008) Mild mitochondrial uncoupling in mice affects energy metabolism, redox balance and longevity. Aging Cell 7:552–560. https://doi.org/10.1111/j.1474-9726.2008.00407.x

Article  CAS  PubMed  Google Scholar 

Oliva CR, Moellering DR, Gillespie GY, Griguer CE (Sep. 2011) Acquisition of chemoresistance in gliomas is associated with increased mitochondrial coupling and decreased ROS production. PLoS ONE 6. https://doi.org/10.1371/journal.pone.0024665

Salazar-Ramiro A et al Role of redox status in development of glioblastoma. Apr 2016 Front Media S A https://doi.org/10.3389/fimmu.2016.00156

Liu Y, Zhou F, Ali H, Lathia JD, Chen P (2024) Immunotherapy for glioblastoma: current state, challenges, and future perspectives, Cell Mol Immunol, vol. 21, pp. 1354–1375, Oct. https://doi.org/10.1038/s41423-024-01226-x