El-Naggar AK, Chan JKC, Grandis JR et al (2022) WHO classification of head and neck tumours. International Agency for Research on Cancer, Lyon

Google Scholar 

He X, Pang Z, Zhang X et al (2018) Consistent amplification of FRS2 and MDM2 in Low-grade osteosarcoma: A genetic study of 22 cases with clinicopathologic analysis. Am J Surg Pathol 42(9):1143–1155. https://doi.org/10.1097/pas.0000000000001125

Article  PubMed  Google Scholar 

Jour G, Gullet A, Liu M et al (2015) Prognostic relevance of fédération Nationale des centres de lutte Contre Le Cancer grade and MDM2 amplification Levels in dedifferentiated liposarcoma: a study of 50 cases. Mod Pathol 28(1):37–47. https://doi.org/10.1038/modpathol.2014.88

Article  CAS  PubMed  Google Scholar 

Nomura K, Tomita M, Kuroda K et al (2024) Overdiagnosis of atypical lipomatous tumors/well-differentiated liposarcomas by morphological diagnosis using only HE stained specimens: a case-control study with MDM2/CDK4 immunostaining and MDM2/CDK4 fluorescence in situ hybridization. BMC Cancer 24(1):1437. https://doi.org/10.1186/s12885-024-13215-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Somaiah N, Tap W (2024) MDM2-p53 in liposarcoma: the need for targeted therapies with novel mechanisms of action. Cancer Treat Rev 122:102668. https://doi.org/10.1016/j.ctrv.2023.102668

Article  CAS  PubMed  Google Scholar 

Sherlin HJ, Natesan A, Ram P et al (2013) Immunohistochemical profiling of ameloblastomas using cytokeratin, vimentin, smooth muscle actin, CD34 and S100. Ann Maxillofac Surg 3(1):51–57. https://doi.org/10.4103/2231-0746.110084

Article  PubMed  PubMed Central  Google Scholar 

Lim D, Tan CC, Tilakaratne WM et al (2022) Sclerosing odontogenic carcinoma - review of all published cases: is it a justifiable addition as a malignancy? Braz J Otorhinolaryngol 88(1):118–129. https://doi.org/10.1016/j.bjorl.2021.01.007

Article  PubMed  Google Scholar 

Labrador AJ, P NRG, Marin LHM, Valdez et al (2022) Clear cell odontogenic carcinoma a systematic review. Head Neck Pathol 16(3):838–848. https://doi.org/10.1007/s12105-021-01383-9

Article  PubMed  Google Scholar 

Kommoss FK, Chang KT, Stichel D et al (2020) Endometrial stromal sarcomas with BCOR-rearrangement harbor MDM2 amplifications. J Pathol Clin Res 6(3):178–184. https://doi.org/10.1002/cjp2.165

Article  CAS  PubMed  PubMed Central  Google Scholar 

He J, Zhao X, Huang C et al (2018) Double amplifications of CDK4 and MDM2 in a gastric inflammatory myofibroblastic tumor mimicking cancer with local invasion of the spleen and diaphragm. Cancer Biol Ther 19(11):967–972. https://doi.org/10.1080/15384047.2018.1480290

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gašljević G, Vivod G, P Škerl et al (2023) Clear cell carcinoma arising in Low-Grade mullerian adenosarcoma: first reported case with insight into molecular profile. Case Rep Oncol 16(1):1335–1344. https://doi.org/10.1159/000531988

Article  PubMed  PubMed Central  Google Scholar 

Cui Y, Han L, Shang J et al (2022) Primary cardiac undifferentiated pleomorphic sarcoma is associated with TP53 mutation during lack of MDM2 amplification, and targeted sequencing analysis reveals potentially actionable targets. Hum Pathol 123:113–122. https://doi.org/10.1016/j.humpath.2022.02.006

Article  CAS  PubMed  Google Scholar 

Giner F, Machado I, Rubio-Martínez LA et al (2023) Intimal sarcoma with MDM2/CDK4 amplification and p16 overexpression: A review of histological features in primary tumor and xenograft, with immunophenotype and molecular profiling. Int J Mol Sci 24:8. https://doi.org/10.3390/ijms24087535

Article  Google Scholar 

Martinez-Monleon A, Kryh Öberg H, Gaarder J et al (2022) Amplification of CDK4 and MDM2: a detailed study of a high-risk neuroblastoma subgroup. Sci Rep 12(1):12420. https://doi.org/10.1038/s41598-022-16455-1

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang S, Yang Y, Li J et al (2024) GLI1, CDK4, and MDM2 Co-Amplification gastric plexiform fibromyxoma: A case report and literature review. Genes Chromosomes Cancer 63(11):e70005. https://doi.org/10.1002/gcc.70005

Article  CAS  PubMed  Google Scholar 

Creytens D, van Gorp J, Ferdinande L et al (2015) Detection of MDM2/CDK4 amplification in lipomatous soft tissue tumors from formalin-fixed, paraffin-embedded tissue: comparison of multiplex ligation-dependent probe amplification (MLPA) and fluorescence in situ hybridization (FISH). Appl Immunohistochem Mol Morphol 23(2):126–133. https://doi.org/10.1097/pdm.0000000000000041

Article  CAS  PubMed  Google Scholar 

Huang WK, Huang SC, Chen CM et al (2023) Marked response to larotrectinib in pelvic spindle cell sarcoma with concurrent TPM3-NTRK1 fusion and CDK4/MDM2 amplification: A case report. JCO Precis Oncol 7:e2200528. https://doi.org/10.1200/po.22.00528

Article  PubMed  PubMed Central  Google Scholar 

Hirose K, Okura M, Sato S et al (2017) Gnathic giant-cell-rich conventional osteosarcoma with MDM2 and CDK4 gene amplification. Histopathology 70(7):1171–1173. https://doi.org/10.1111/his.13141

Article  PubMed  Google Scholar 

Chen PC, Yen CC, Hung GY et al (2019) Gene amplification and tumor grading in parosteal osteosarcoma. J Chin Med Assoc 82(12):889–894. https://doi.org/10.1097/jcma.0000000000000211

Article  PubMed  Google Scholar 

Suehara Y, Alex D, Bowman A et al (2019) Clinical genomic sequencing of pediatric and adult osteosarcoma reveals distinct molecular subsets with potentially targetable alterations. Clin Cancer Res 25(21):6346–6356. https://doi.org/10.1158/1078-0432.Ccr-18-4032

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ladanyi M, Lewis R, Jhanwar SC et al (1995) MDM2 and CDK4 gene amplification in ewing’s sarcoma. J Pathol 175(2):211–217. https://doi.org/10.1002/path.1711750209

Article  CAS  PubMed  Google Scholar 

Colecchia M, Bertolotti A, Paolini B et al (2021) The Leydig cell tumour scaled score (LeSS): a method to distinguish benign from malignant cases, with additional correlation with MDM2 and CDK4 amplification. Histopathology 78(2):290–299. https://doi.org/10.1111/his.14225

Article  PubMed  Google Scholar 

Benito R, Gil-Benso R, Quilis V et al (2010) Primary glioblastomas with and without EGFR amplification: relationship to genetic alterations and clinicopathological features. Neuropathology 30(4):392–400. https://doi.org/10.1111/j.1440-1789.2009.01081.x

Article  PubMed  Google Scholar 

Makise N, Sekimizu M, Kubo T et al (2018) Extraskeletal osteosarcoma: MDM2 and H3K27me3 analysis of 19 cases suggest disease heterogeneity. Histopathology 73(1):147–156. https://doi.org/10.1111/his.13506

Article  PubMed  Google Scholar 

Piscuoglio S, Burke KA, Ng CK et al (2016) Uterine adenosarcomas are mesenchymal neoplasms. J Pathol 238(3):381–388. https://doi.org/10.1002/path.4675

Article  CAS  PubMed  Google Scholar 

Jang H, Ryu HJ, Kim SK (2023) Genetic Characteristics of Primary Cutaneous Malignant Melanoma in Koreans Compared With Western Populations. In Vivo 37(2): 862–867.https://doi.org/10.21873/invivo.13154

Simon R, Struckmann K, Schraml P et al (2002) Amplification pattern of 12q13-q15 genes (MDM2, CDK4, GLI) in urinary bladder cancer. Oncogene 21(16):2476–2483. https://doi.org/10.1038/sj.onc.1205304

Article  CAS  PubMed  Google Scholar 

Grünewald I, Trautmann M, Busch A et al (2016) MDM2 and CDK4 amplifications are rare events in salivary duct carcinomas. Oncotarget 7(46):75261–75272. https://doi.org/10.18632/oncotarget.12127

Article  PubMed  PubMed Central  Google Scholar 

Meric-Bernstam F, Frampton GM, Ferrer-Lozano J et al (2014) Concordance of genomic alterations between primary and recurrent breast cancer. Mol Cancer Ther 13(5):1382–1389. https://doi.org/10.1158/1535-7163.Mct-13-0482

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alsugair Z, Fieux M, Descotes F et al (2024) Peculiar nuclear atypia associated with MDM2 gene amplification in carcinoma ex-pleomorphic adenoma harbouring an alteration of HMGA2. Histopathology 85(2):338–346.