Japan Intractable Diseases Information Center. https://www.nanbyou.or.jp (Japanese)
Guidelines for the diagnosis and treatment of Werner syndrome. Yokote K, Takemoto M. Nippon Ronen Igakkai Zasshi 2013;50:417–427.(Japanese)
Takemoto M, Mori S, Kuzuya M, et al. Diagnostic criteria for Werner syndrome based on Japanese nationwide epidemiological survey. Geriatr Gerontol Int. 2013;13:475–81.
Murata K, Nakashima H. Clinical and metabolic studies on Werner’s syndrome:with special reference to disorders of lipid and liver function. Adv Exp Med Biol. 1985;190:285–304.
Mori S, Morisaki N, Murano S, et al. Fatty liver as a complication of patients with Werner’s syndrome. Jpn J Geriat 1988;25:626–631. (Japanese)
Lee J, Vail Y, Boursier J, et al. Prognostic accuracy of Fib-4, NAFLD fibrosis score and APRI for NAFLD-related events: a systematic review. Liver Int. 2021;41:261–70.
PubMed PubMed Central Google Scholar
Singh S, Allen AM, Wang Z, et al. Fibrosis progression in nonalcoholic fatty liver vs nonalcoholic steatohepatitis: a systematic review and meta-analysis of paired-biopsy studies. Clin Gastroenterol Hepatol. 2015;13:643–54.; quiz e39–40.
Hashizume H, Sato K, Takagi H, et al. Werner syndrome as a possible cause of non-alcoholic steatohepatitis.J Clin Pathol 2009;62:1043–1045.
Imura H, Nakao Y, Kuzuya H, et al. Clinical, endocrine and metabolic aspects of the Werner syndrome compared with those of normal aging. Adv Exp Med Biol. 1985;190:171–85.
Tsukamoto K, Takemoto M, Kubota Y, et al. Management guideline for Werner syndrome 2020 1. Dyslipidemia and fatty liver associated with Werner syndrome. Geriatr Gerontol Int 2021;21:133–138.
Sogawa M, Kasuya S, Yamamoto K, et al. Aortic valve replacement for aortic stenosis with a small aortic annulus in a patient having Werner’s syndrome and liver cirrhosis. Ann Thorac Cardiovasc Surg. 2001;7:378–80.
Hakeem A, Reza S, Moinuddin S, et al. Cirrhosis in Werner’s syndrome: an unusual presentation of premature aging. Med Sci Monit 2007;13:CS61–66.
Amalnath SD, Sargolzaeiaval F, Oshima J, et al. Uncommon cause of cirrhosis: a case of Werner syndrome with a novel WRN mutation. Indian J Gastroenterol. 2017;36:323–5.
PubMed PubMed Central Google Scholar
Kuzuya M, Shi RQ, Yanagawa M, et al. Long-lived Werner syndrome patient autopsy report: the presence of liver cirrhosis. Geriatr Gerontol Int. 2021;21:433–5.
Yu CE, Oshima J, Fu YH, et al. Positional cloning of the Werner’s syndrome gene. Science. 1996;272:258–62.
Maezawa Y. Basic science of Werner syndrome. Jpn J Geriat 2021;58:402–408. (Japanese)
Shamanna RA, Lu H, de Freitas JK, Tian J et al. WRN regulates pathway choice between classical and alternative non-homologus end joining. Nature Commun. 7:13785.
Tokita M, Kennedy SR, Risques RA et al. Werner syndrome through the lens of tissue and tumour genomics. Sci Rep. 6:32038.
Kato H, Maezawa Y, Takayama N, et al. Fibroblasts from different body parts exhibit distinct phenotypes in adult progeria Werner syndrome. Aging (Albany NY). 2021;13:4946–61.
Tu J, Wan C, Zhang F, et al. Genetic correction of Werner syndrome gene reveals impaired pro-angiogemic function and HGF insufficiency in mesenchymal stem cells. Aging Cell 2020;19:e13116.
Tokushige K, Ikejima K, Ono M, et al. Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis 2020. J Gastroenterol. 2021;56:951–63.
PubMed PubMed Central Google Scholar
Yoshiji H, Nagoshi S, Akahane T, et al. Evidence-based clinical practice guidelines for Liver Cirrhosis 2020. J Gastroenterol. 2021;56:593–619.
PubMed PubMed Central Google Scholar
Belfort R, Harrison SA, Brown K, et al. A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis. N Eng J Med. 2006;355:2297–307.
The Japanese Society of Gastroenterology, The Japanese Society of Hepatology. Evidence-based Clinical Practice Guidelines for Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis 2020 (2nd edition). (Japanese)
Takemoto M, Yamaga M, Furuichi Y, et al. Astaxanthin improves nonalcoholic fatty liver disease in Werner syndrome with diabetes mellitus. J Am Geriatr Soc. 2015;63:1271–3.
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