A Meta-Analysis of the Association between Apolipoprotein E Polymorphisms and SARS-COV-2 Risk/Severity in the Korean Population

WHO, WHO statement regarding cluster of pneumonia cases in Wuhan, China, 2020. https://www.who.int/hongkongchina/news/detail/09-01-2020-who-statement-regarding-cluster-of-pneumonia-cases-in-wuhan-china. Accessed June 4, 2024.

WHO, WHO COVID-19 dashboard.

Wu, F., Zhao, S., Yu, B., et al., A new coronavirus associated with human respiratory disease in China, Nature, 2020, vol. 579, no. 7798, pp. 265-269. https://doi.org/10.1038/s41586-020-2008-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lu, R., Zhao, X., Li, J., et al., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding, Lancet, 2020, vol. 395, no. 10224, pp. 565-574. https://doi.org/10.1016/S0140-6736(20)30251-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen, N., Zhou, M., Dong, X., et al., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study, Lancet, 2020, vol. 395, no. 10223, pp. 507-513. https://doi.org/10.1016/S0140-6736(20)30211-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Davies, N.G., Klepac, P., Liu, Y., Prem, K., and Jit, M., CMMID COVID-19 working group, and Eggo, R.M., Age-dependent effects in the transmission and control of COVID-19 epidemics, Nat. Med., 2020, vol. 26, no. 8, pp. 1205-1211. https://doi.org/10.1038/s41591-020-0962-9

Article  CAS  PubMed  Google Scholar 

Liu, Y., Mao, B., Liang, S., et al., Association between age and clinical characteristics and outcomes of COVID-19, Eur. Respir. J., 2020, vol. 55, no. 5, p. 2001112. https://doi.org/10.1183/13993003.01112-2020

Article  CAS  PubMed  PubMed Central  Google Scholar 

Takahashi, T., Ellingson, M.K., Wong, P., et al., Sex differences in immune responses that underlie COVID-19 disease outcomes, Nature, 2020, vol. 588, no. 7837, pp. 315-320. https://doi.org/10.1038/s41586-020-2700-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Grasselli, G., Zangrillo, A., Zanella, A., et al., Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy Region, Italy, JAMA, 2020, vol. 323, no. 16, pp. 1574-1581. https://doi.org/10.1001/jama.2020.5394

Article  CAS  PubMed  PubMed Central  Google Scholar 

Russell, C.D., Lone, N.I., and Baillie, J.K., Comorbidities, multimorbidity and COVID-19, Nat. Med., 2023, vol. 29, no. 2, pp. 334-343. https://doi.org/10.1038/s41591-022-02156-9

Article  CAS  PubMed  Google Scholar 

Li, X., Xu, S., Yu, M., et al., Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan, J. Allergy Clin. Immunol., 2020, vol. 146, no. 1, pp. 110-118. https://doi.org/10.1016/j.jaci.2020.04.006

Article  CAS  PubMed  PubMed Central  Google Scholar 

Williams, F.M., Freidin, M.B., Mangino, M., et al., Self-reported symptoms of COVID-19, including symptoms most predictive of SARS-CoV-2 infection, are heritable, Twin. Res. Hum. Genet., 2020, vol. 23, no. 6, pp. 316-321. https://doi.org/10.1017/thg.2020.85

Article  PubMed  Google Scholar 

Eshetie, S., Jullian, P., Benyamin, B., and Lee, S. H., Host genetic determinants of COVID-19 susceptibility and severity: a systematic review and meta-analysis, Rev. Med. Virol., 2023, vol. 33, no. 5, p. e2466. https://doi.org/10.1002/rmv.2466

Article  CAS  PubMed  Google Scholar 

Niemi, M.E., Daly, M.J., an Ganna, A., The human genetic epidemiology of COVID-19, Nat. Rev. Genet., 2022, vol. 23, no. 9, pp. 533-546. https://doi.org/10.1038/s41576-022-00478-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dieter, C., Brondani, L.A., Leitão, C.B., et al., Genetic polymorphisms associated with susceptibility to COVID-19 disease and severity: a systematic review and meta-analysis, PLoS One, 2022, vol. 17, no. 7, p. e0270627. https://doi.org/10.1371/journal.pone.0270627

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yildirim, Z., Sahin, O.S., Yazar, S., and Bozok Cetintas, V., Genetic and epigenetic factors associated with increased severity of Covid-19, Cell Biol. Int., 2021, vol. 45, no. 6, pp. 1158-1174. https://doi.org/10.1002/cbin.11572

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dobrijević, Z., Gligorijević, N., Šunderić, M., et al., The association of human leucocyte antigen (HLA) alleles with COVID-19 severity: a systematic review and meta-analysis, Rev. Med. Virol., 2023, vol. 33, no. 1, p. e2378. https://doi.org/10.1002/rmv.2378

Article  CAS  PubMed  Google Scholar 

Kim, Y.-C. and Jeong, B.-H., Strong correlation between the case fatality rate of COVID-19 and the rs6598045 single nucleotide polymorphism (SNP) of the interferon-induced transmembrane protein 3 (IFITM3) gene at the population-level, Genes, 2020, vol. 12, no. 1, p. 42. https://doi.org/10.3390/genes12010042

Article  CAS  PubMed  PubMed Central  Google Scholar 

Getz, G.S. and Reardon, C.A., Apoprotein E as a lipid transport and signaling protein in the blood, liver, and artery wall, J. Lipid. Res., 2009, vol. 50, suppl., pp. S156-S161. https://doi.org/10.1194/jlr.R800058-JLR200

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mahley, R.W. and Rall, S.C., Jr., Apolipoprotein E: far more than a lipid transport protein, Annu. Rev. Genomics Hum. Genet., 2000, vol. 1, no. 1, pp. 507-537. https://doi.org/10.1146/annurev.genom.1.1.507

Article  CAS  PubMed  Google Scholar 

Hubáček, J., Adamkova, V., and Škodova, Z., Rare variant of apolipoprotein E (Arg136→Ser) in two normolipidemic individuals, Physiol. Res., 2005, vol. 54, no. 5, pp. 573-575.

PubMed  Google Scholar 

Touré, M., Diouf, N.N., Thiam, S., et al., Frequencies and distribution of APOE gene polymorphisms and its association with lipid parameters in the Senegalese population, Cureus, 2022, vol. 14, no. 4, p. e24063. https://doi.org/10.7759/cureus.24063

PubMed  PubMed Central  Google Scholar 

Abondio, P., Sazzini, M., Garagnani, P., et al., The genetic variability of APOE in different human populations and its implications for longevity, Genes (Basel), 2019, vol. 10, no. 3, p. 222. https://doi.org/10.3390/genes10030222

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mahley, R., Nathan, B.P., and Pitas, R.E., Apolipoprotein E: structure, function, and possible roles in Alzheimer’s disease, Ann. N. Y. Acad. Sci., 1996, vol. 777, no. 1, pp. 139-145. https://doi.org/10.1111/j.1749-6632.1996.tb34412.x

Article  CAS  PubMed  Google Scholar 

Morrow, J.A., Segall, M.L., Lund-Katz, S., et al., Differences in stability among the human apolipoprotein E isoforms determined by the amino-terminal domain, Biochemistry, 2000, vol. 39, no. 38, pp. 11657-11666. https://doi.org/10.1021/bi000099m

Article  CAS  PubMed  Google Scholar 

Chen, Y., Strickland, M. R., Soranno, A., and Holtzman, D., Apolipoprotein E: structural insights and links to Alzheimer disease pathogenesis, Neuron, 2021, vol. 109, no. 2, pp. 205-221. https://doi.org/10.1016/j.neuron.2020.10.008

Article  CAS  PubMed  Google Scholar 

Raulin, A.-C., Kraft, L., Al-Hilaly, Y.K., et al., The molecular basis for apolipoprotein E4 as the major risk factor for late-onset Alzheimer’s disease, J. Mol. Biol., 2019, vol. 431, no. 12, pp. 2248-2265. https://doi.org/10.1016/j.jmb.2019.04.019.

CAS  PubMed  PubMed Central  Google Scholar 

Liu, C.C., Liu, C.C., Kanekiyo, T., et al., Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy, Nat. Rev. Neurol., 2013, vol. 9, no. 2, pp. 106-118. https://doi.org/10.1038/nrneurol.2012.263

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fyfe, I., APOE ε4 influences Parkinson disease progression, Nat. Rev. Neurol., 2021, vol. 17, no. 12, pp. 726-726.

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