Cruz-Jentoft AJ, Sayer AA. Sarcopenia. Lancet. 2019;393:2636–46.

Article  PubMed  Google Scholar 

Dent E, Morley JE, Cruz-Jentoft AJ, Arai H, Kritchevsky SB, Guralnik J, et al. International clinical practice guidelines for sarcopenia (ICFSR): screening, diagnosis and management. J Nutr Health Aging. 2018;22:1148–61.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gustafsson T, Ulfhake B. Sarcopenia: what is the origin of this aging-induced disorder? Front Genet. 2021;12: 688526.

Article  PubMed  PubMed Central  Google Scholar 

Papadopoulou SK. Sarcopenia: a contemporary health problem among older adult populations. Nutrients. 2020;12:1293.

Article  PubMed  PubMed Central  Google Scholar 

Senior HE, Henwood TR, Beller EM, Mitchell GK, Keogh JW. Prevalence and risk factors of sarcopenia among adults living in nursing homes. Maturitas. 2015;82:418–23.

Article  PubMed  Google Scholar 

Westbury LD, Beaudart C, Bruyère O, Cauley JA, Cawthon P, Cruz-Jentoft AJ, et al. Recent sarcopenia definitions-prevalence, agreement and mortality associations among men: findings from population-based cohorts. J Cachexia Sarcopenia Muscle. 2023;14:565–75.

Article  PubMed  PubMed Central  Google Scholar 

Bauer J, Morley JE, Schols AMWJ, Ferrucci L, Cruz-Jentoft AJ, Dent E, et al. Sarcopenia: a time for action. An SCWD position paper. J Cachexia Sarcopenia Muscle. 2019;10:956–61.

Article  PubMed  PubMed Central  Google Scholar 

Chen TH. Comment on: “Myostatin inhibition in combination with antisense oligonucleotide therapy improves outcomes in spinal muscular atrophy” by Zhou et al. J Cachexia Sarcopenia Muscle. 2020;11:1377–8.

Article  PubMed  PubMed Central  Google Scholar 

Nishikawa H, Nishiguchi S. Sarcopenia and sarcopenic obesity are prognostic factors for overall survival in patients with cirrhosis. Intern Med. 2016;55:855–6.

Article  PubMed  Google Scholar 

Tournadre A, Vial G, Capel F, Soubrier M, Boirie Y. Sarcopenia. Joint Bone Spine. 2019;86:309–14.

Article  PubMed  Google Scholar 

Cacciani N, Skärlén Å, Wen Y, Zhang X, Addinsall AB, Llano-Diez M, et al. A prospective clinical study on the mechanisms underlying critical illness myopathy-a time-course approach. J Cachexia Sarcopenia Muscle. 2022;13:2669–82.

Article  PubMed  PubMed Central  Google Scholar 

Schweickert WD, Patel BK, Kress JP. Timing of early mobilization to optimize outcomes in mechanically ventilated ICU patients. Intensive Care Med. 2022;48:1305–7.

Article  PubMed  PubMed Central  Google Scholar 

Rooks D, Swan T, Goswami B, Filosa LA, Bunte O, Panchaud N, et al. Bimagrumab vs optimized standard of care for treatment of sarcopenia in community-dwelling older adults: a randomized clinical trial. JAMA Netw Open. 2020;3: e2020836.

Article  PubMed  PubMed Central  Google Scholar 

Yadav A, Yadav SS, Singh S, Dabur R. Natural products: potential therapeutic agents to prevent skeletal muscle atrophy. Eur J Pharmacol. 2022;925: 174995.

Article  CAS  PubMed  Google Scholar 

Zazzara MB, Penfold RS, Onder G. The Future of Drugs in Sarcopenia. In: Veronese N, Beaudart C, Sabico S, editors. Sarcopenia: Research and Clinical Implications. Switzerland: Springer Cham; 2021. p. 181–208.

Chapter  Google Scholar 

Cho MR, Lee S, Song SK. A review of sarcopenia pathophysiology, diagnosis, treatment and future direction. J Korean Med Sci. 2022;37: e146.

Article  PubMed  PubMed Central  Google Scholar 

Zheng Y, Feng J, Yu Y, Ling M, Wang X. Advances in sarcopenia: mechanisms, therapeutic targets, and intervention strategies. Arch Pharm Res. 2024;47:301–24.

Article  CAS  PubMed  Google Scholar 

Najm A, Niculescu AG, Grumezescu AM, Beuran M. Emerging therapeutic strategies in sarcopenia: an updated review on pathogenesis and treatment advances. Int J Mol Sci. 2024;25: 4300.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tian X, Pan M, Zhou M, Tang Q, Chen M, Hong W, Zhao F, Liu K. Mitochondria transplantation from stem cells for mitigating sarcopenia. Aging Dis. 2023;14:1700.

Article  PubMed  PubMed Central  Google Scholar 

Haroon M, Boers HE, Bakker AD, Bloks NGC, Hoogaars WMH, et al. Reduced growth rate of aged muscle stem cells is associated with impaired mechanosensitivity. Aging (Albany NY). 2022;14:28–53.

Article  CAS  PubMed  Google Scholar 

Wong RSY, Cheong SK. Therapeutic potential of mesenchymal stem cells and their derivatives in sarcopenia. Malays J Pathol. 2022;44:429–42.

CAS  PubMed  Google Scholar 

Wang C, Zhao B, Zhai J, Wang A, Cao N, Liao T, Su R, He L, Li Y, Pei X, Jia Y, Yue W. Clinical-grade human umbilical cord-derived mesenchymal stem cells improved skeletal muscle dysfunction in age-associated sarcopenia mice. Cell Death Dis. 2023;14:321.

Article  PubMed  PubMed Central  Google Scholar 

Wang BY, Hsiao AW, Shiu HT, Wong N, Wang AY, Lee CW, Lee OK, Lee WY. Mesenchymal stem cells alleviate dexamethasone-induced muscle atrophy in mice and the involvement of ERK1/2 signalling pathway. Stem Cell Res Ther. 2023;14:195.

Article  PubMed  PubMed Central  Google Scholar 

Oh SY, Choi YM, Kim HY, Park YS, Jung SC, Park JW, et al. Application of tonsil-derived mesenchymal stem cells in tissue regeneration: concise review. Stem Cells. 2019;37:1252–60.

Article  PubMed  Google Scholar 

Park S, Choi Y, Jung N, Yu Y, Ryu KH, Kim HS, et al. Myogenic differentiation potential of human tonsil-derived mesenchymal stem cells and their potential for use to promote skeletal muscle regeneration. Int J Mol Med. 2016;37:1209–20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Park S, Jeong S, Nam YH, Yum Y, Jung SC. Transplantation of differentiated tonsil-derived mesenchymal stem cells ameliorates murine Duchenne muscular dystrophy via autophagy activation. Tissue Eng Regen Med. 2022;19:1283–94.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Choi Y, Nam YH, Jeong S, Lee HY, Choi SY, Park S, Jung SC. Biochemical and functional characterization of skeletal muscle cells differentiated from tonsil-derived mesenchymal stem cells. Muscle Nerve. 2023;68:219–29.

Article  CAS  PubMed  Google Scholar 

Baraniak PR, McDevitt TC. Scaffold-free culture of mesenchymal stem cell spheroids in suspension preserves multilineage potential. Cell Tissue Res. 2012;347:701–11.

Article  CAS  PubMed  Google Scholar 

Lee YB, Kim EM, Byun H, Chang HK, Jeong K, Aman ZM, et al. Engineering spheroids potentiating cell-cell and cell-ECM interactions by self-assembly of stem cell microlayer. Biomaterials. 2018;165:105–20.

Article  CAS  PubMed  Google Scholar 

Bartosh TJ, Ylöstalo JH, Mohammadipoor A, Bazhanov N, Coble K, Claypool K, et al. Aggregation of human mesenchymal stromal cells (MSCs) into 3d spheroids enhances their antiinflammatory properties. Proc Natl Acad Sci U S A. 2010;107:13724–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Besser RR, Bowles AC, Alassaf A, Carbonero D, Maciel R, Saporta M, Agarwal A. A chemically defined common medium for culture of C2C12 skeletal muscle and human induced pluripotent stem cell derived spinal spheroids. Cell Mol Bioeng. 2020;13:605–19.

Article  CAS  PubMed  PubMed Central