Salama M, Coachman C, Garber D, Calamita M, Salama H, Cabral G. Prosthetic gingival reconstruction in the fixed partial restoration. Part 2: diagnosis and treatment planning. Int J Periodontics Restorative Dent. 2009;29:573–81.

PubMed  Google Scholar 

An H-S, Park J-M, Park E-J. Evaluation of shear bond strengths of gingiva-colored composite resin to porcelain, metal and zirconia substrates. J Adv Prosthodont. 2011;3:166.

Article  PubMed  PubMed Central  Google Scholar 

Fushiki R, Komine F, Kimura F, Kusaba K, Kondo T, Moriya Y, et al. Bond strengths between gingiva-colored layering resin composite and zirconia frameworks coated with feldspathic porcelain. Dent Mater J. 2019;38:547–54.

Article  PubMed  CAS  Google Scholar 

Pong MT, Grymak A, Waddell JN, Choi JJE. Bond strength between CAD/CAM PMMA denture base resins and characterisation composites. Oral. 2022;2:75–87.

Article  Google Scholar 

Rizo-Gorrita M, Herráez-Galindo C, Torres-Lagares D, Serrera-Figallo M-Á, Gutiérre-Pérez J-L. Biocompatibility of polymer and ceramic CAD/CAM materials with human gingival fibroblasts (HGFs). Polymers. 2019;11:1446.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Han J, Leeuwenburgh SCG, Jansen JA, Yang F, Van Oirschot BAJA. Biological processes in gingival tissue integration around dental implants. Tissue Eng Part B Rev. 2024;31:1–19.

Article  PubMed  Google Scholar 

Nandini S. Indirect resin composites. J Conserv Dent. 2010;13:184.

Article  PubMed  PubMed Central  Google Scholar 

Odabasi D, Guler C, Kucukaslan D. Evaluation of the amount of residual monomer released from different flowable composite resins. BMC Oral Health. 2024;24:244.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Rosa V, Silikas N, Yu B, Dubey N, Sriram G, Zinelis S, et al. Guidance on the assessment of biocompatibility of biomaterials: fundamentals and testing considerations. Dent Mater. 2024;40:1773–85.

Article  PubMed  CAS  Google Scholar 

Zieniewska I, Maciejczyk M, Zalewska A. The effect of selected dental materials used in conservative dentistry, endodontics, surgery, and orthodontics as well as during the periodontal treatment on the redox balance in the oral cavity. IJMS. 2020;21:9684.

Article  PubMed  PubMed Central  CAS  Google Scholar 

van Landuyt KL, Krifka S, Hiller K-A, Bolay C, Waha C, van Meerbeek B, et al. Evaluation of cell responses toward adhesives with different photoinitiating systems. Dent Mater. 2015;31:916–27.

Article  PubMed  Google Scholar 

Bakopoulou A. Molecular toxicology of substances released from resin-based dental restorative materials. Int J Mol Sci. 2009;10:3861–99.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Beltrami R, Colombo M, Rizzo K, di Cristofaro A, Poggio C, Pietrocola G. Cytotoxicity of different composite resins on human gingival fibroblast cell lines. Biomimetics. 2021;6:26.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kraus D, Wolfgarten M, Enkling N, Helfgen E-H, Frentzen M, Probstmeier R, et al. In-vitro cytocompatibility of dental resin monomers on osteoblast-like cells. J Dent. 2017;65:76–82.

Article  PubMed  CAS  Google Scholar 

Goenka S. In vitro evaluation of dental resin monomers, triethylene glycol dimethacrylate (TEGDMA), and 2-hydroxyethyl methacrylate (HEMA) in primary human melanocytes: a pilot study. Oral. 2023;3:353–71.

Article  Google Scholar 

Reichl F-X, Walther UI, Durner J, Kehe K, Hickel R, Kunzelmann K-H, et al. Cytotoxicity of dental composite components and mercury compounds in lung cells. Dent Mater. 2001;17:95–101.

Article  PubMed  CAS  Google Scholar 

Neves SO, Magalhães LMD, Corrêa JD, Dutra WO, Gollob KJ, Silva TA, et al. Composite-derived monomers affect cell viability and cytokine expression in human leukocytes stimulated with Porphyromonas gingivalis. J Appl Oral Sci. 2019;27:e20180529.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Wiertelak-Makała K, Szymczak-Pajor I, Bociong K, Śliwińska A. Considerations about cytotoxicity of resin-based composite dental materials: a systematic review. Int J Mol Sci. 2023;25:152.

Article  PubMed  PubMed Central  Google Scholar 

Chang C-Y, Chiang C-Y, Chiang Y-W, Lee M-W, Lee C-Y, Chen H-Y, et al. Toxic effects of urethane dimethacrylate on macrophages through caspase activation, mitochondrial dysfunction, and reactive oxygen species generation. Polymers. 2020;12:1398.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chen F, Shi X. Signaling from toxic metals to NF-κB and beyond: not just a matter of reactive oxygen species. Environ Health Perspect. 2002;110:807–11.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Korunes KL, Liu J, Huang R, Xia M, Houck KA, Corton JC. A gene expression biomarker for predictive toxicology to identify chemical modulators of NF-κB. PLoS One. 2022;17:e0261854 (Punj V, editor).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Schweikl H, Spagnuolo G, Schmalz G. Genetic and cellular toxicology of dental resin monomers. J Dent Res. 2006;85:870–7.

Article  PubMed  CAS  Google Scholar 

Spagnuolo G, Mauro C, Leonardi A, Santillo M, Paternò R, Schweikl H, et al. NF-κB protection against apoptosis induced by HEMA. J Dent Res. 2004;83:837–42.

Article  PubMed  CAS  Google Scholar 

Pagano S, Coniglio M, Valenti C, Negri P, Lombardo G, Costanzi E, et al. Biological effects of resin monomers on oral cell populations: descriptive analysis of literature. Eur J Paediatr Dent. 2019. https://doi.org/10.23804/ejpd.2019.20.03.11.

Article  PubMed  Google Scholar 

Kondo T, Kakinuma H, Fujimura K, Ambo S, Otake K, Sato Y, et al. Incomplete polymerization of dual-cured resin cement due to attenuated light through Zirconia induces inflammatory responses. IJMS. 2023;24:9861.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Juráňová J. Illuminating the cellular and molecular mechanism of the potential toxicity of methacrylate monomers used in biomaterials. Drug Chem Toxicol. 2020;43:266–78.

Article  PubMed  Google Scholar 

Anand SK, Sharma A, Singh N, Kakkar P. Entrenching role of cell cycle checkpoints and autophagy for maintenance of genomic integrity. DNA Repair. 2020;86:102748.

Article  PubMed  CAS  Google Scholar 

Abuetabh Y, Wu HH, Chai C, Al Yousef H, Persad S, Sergi CM, et al. DNA damage response revisited: the p53 family and its regulators provide endless cancer therapy opportunities. Exp Mol Med. 2022;54:1658–69.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Carr MI, Jones SN. Regulation of the Mdm2-p53 signaling axis in the DNA damage response and tumorigenesis. Transl Cancer Res. 2016;5:707–24.

Article  PubMed  CAS  Google Scholar 

Brooks CL, Gu W. New insights into p53 activation. Cell Res. 2010;20:614–21.

Article  PubMed  CAS  Google Scholar 

Schwartz D, Rotter V. p53-dependent cell cycle control: response to genotoxic stress. Semin Cancer Biol. 1998;8:325–36.

Article