Dey M, Singh RK (2022) Neurotoxic effects of aluminium exposure as a potential risk factor for Alzheimer’s disease. Pharmacol Rep 74:439–450. https://doi.org/10.1007/s43440-022-00353-4

Article  CAS  PubMed  Google Scholar 

Exley C, House ER (2011) Aluminium in the human brain. Monatsh Chem 142:357–363. https://doi.org/10.1007/s00706-010-0417-y

Article  CAS  Google Scholar 

Song Y, Xue Y, Liu X, Wang P, Liu L (2008) Effects of acute exposure to aluminum on blood–brain barrier and the protection of zinc. Neurosci Lett 445:42–46. https://doi.org/10.1016/j.neulet.2008.08.081

Article  CAS  PubMed  Google Scholar 

Rengel Z (2004) Aluminium cycling in the soil-plant-animal-human continuum. Biometals 17:669–689. https://doi.org/10.1007/s10534-004-1201-4

Article  CAS  PubMed  Google Scholar 

Kawahara M, Kato-Negishi M (2011) Link between aluminum and the pathogenesis of Alzheimer’s disease: the integration of the aluminum and amyloid cascade hypotheses. Int J Alzheimers Dis 2011:276393. https://doi.org/10.4061/2011/276393

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stahl T, Taschan H, Brunn H (2011) Aluminium content of selected foods and food products. Environ Sci Eur 23:1–1. https://doi.org/10.1186/2190-4715-23-37

Article  Google Scholar 

Yokel RA, McNamara PJ (2001) Aluminium toxicokinetics: an updated minireview. Pharmacol & Toxicol: MiniReview 88:159–167. https://doi.org/10.1111/j.1600-0773.2001.880401.x

Article  CAS  Google Scholar 

Bryliński Ł, Kostelecka K, Woliński F, Duda P, Góra J, Granat M, Flieger J, Teresiński G, Buszewicz G, Sitarz R, Baj J (2023) Aluminium in the human brain: routes of penetration, toxicity, and resulting complications. Int J Mol Sci 24:7228. https://doi.org/10.3390/ijms24087228

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kronbauer M, Shorstkii I, da Silva SB, Toepfl S, Lammerskitten A, Siemer C (2023) Pulsed electric field assisted extraction of soluble proteins from nettle leaves (Urtica dioica L.): kinetics and optimization using temperature and specific energy. Sustain food technol 1:886–895. https://doi.org/10.1039/D3FB00053B

Article  CAS  Google Scholar 

Albadawi E, El-Tokhy A, Albadrani M, Adel M, El-Gamal R, Zaarina W, El-Agawy MS, Elsayed HR (2024) The role of stinging nettle (Urtica dioica L.) in the management of rotenone-induced Parkinson’s disease in rats. Tissue Cell 87:102328. https://doi.org/10.1016/j.tice.2024.102328

Article  CAS  PubMed  Google Scholar 

Orčić D, Francišković M, Bekvalac K, Svirčev E, Beara I, Lesjak M, Mimica-Dukić N (2014) Quantitative determination of plant phenolics in Urtica dioica extracts by high-performance liquid chromatography coupled with tandem mass spectrometric detection. Food Chem 143:48–53. https://doi.org/10.1016/j.foodchem.2013.07.097

Article  CAS  PubMed  Google Scholar 

Francišković M, Gonzalez-Pérez R, Orčić D, Sanchez de Medina F, Martínez-Augustin O, Svirčev E, Simin N, Mimica-Dukić N (2017) Chemical composition and immuno-modulatory effects of Urtica dioica L. (Stinging Nettle) extracts. Phytother Res 31:1183–1191. https://doi.org/10.1002/ptr.5836

Article  CAS  PubMed  Google Scholar 

Pinelli P, Ieri F, Vignolini P, Bacci L, Baronti S, Romani A (2008) Extraction and HPLC analysis of phenolic compounds in leaves, stalks, and textile fibers of Urtica dioica L. J Agric Food Chem 56:9127–9132. https://doi.org/10.1021/jf801552d

Article  CAS  PubMed  Google Scholar 

Kutlu G, Bozkurt F, Tornuk F (2020) Extraction of a novel water-soluble gum from nettle (Urtica dioica) seeds: optimization and characterization. Int J Biol Macromol 162:480–489. https://doi.org/10.1016/j.ijbiomac.2020.06.179

Article  CAS  PubMed  Google Scholar 

Patel SS, Parashar A, Udayabanu M (2015) Urtica dioica leaves modulates muscarinic cholinergic system in the hippocampus of streptozotocin-induced diabetic mice. Metab Brain Dis 30:803–811. https://doi.org/10.1007/s11011-014-9646-9

Article  PubMed  Google Scholar 

Choi TY, Choi TI, Lee YR, Choe SK, Kim CH (2021) Zebrafish as an animal model for biomedical research. Exp Mol Med 53:310–317. https://doi.org/10.1038/s12276-021-00571-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kalueff AV, Echevarria DJ, Stewart AM (2014) Gaining translational momentum: more zebrafish models for neuroscience research. Prog Neuropsychopharmacol Biol Psychiatry 55:1–6. https://doi.org/10.1016/j.pnpbp.2014.01.022

Article  PubMed  Google Scholar 

Monaco A, Grimaldi MC, Ferrandino I (2017) Aluminium chloride-induced toxicity in zebrafish larvae. J. Fish Dis 629–35:629. https://doi.org/10.1111/jfd.12544

Article  CAS  Google Scholar 

Capriello T, Grimaldi MC, Cofone R, D’Aniello S, Ferrandino I (2019) Effects of aluminium and cadmium on hatching and swimming ability in developing zebrafish. Chemosphere 222:243–249. https://doi.org/10.1016/j.chemosphere.2019.01.140

Article  CAS  PubMed  Google Scholar 

Rana AK, Singh D (2018) Targeting glycogen synthase kinase-3 for oxidative stress and neuroinflammation: opportunities, challenges and future directions for cerebral stroke management. Neuropharmacology 139:124–136. https://doi.org/10.1016/j.neuropharm.2018.07.006

Article  CAS  PubMed  Google Scholar 

Maurer U, Preiss F, Brauns-Schubert P, Schlicher L, Charvet C (2014) GSK-3–at the crossroads of cell death and survival. J Cell Sci 127:1369–1378. https://doi.org/10.1242/jcs.138057

Article  CAS  PubMed  Google Scholar 

Shang N, Zhang P, Wang S, Chen J, Fan R, Chen J et al (2020) Aluminum-induced cognitive impairment and PI3K/Akt/mTOR signaling pathway involvement in occupational aluminum workers. Neurotox Res 38:344–358. https://doi.org/10.1007/s12640-020-00230-z

Article  CAS  PubMed  Google Scholar 

Sequeira RC, Godad A (2024) Understanding glycogen synthase kinase-3: a novel avenue for Alzheimer’s disease. Mol Neurobiol 61:4203–4221. https://doi.org/10.1007/s12035-023-03839-1

Article  CAS  PubMed  Google Scholar 

Lauretti E, Dincer O, Praticò D (2020) Glycogen synthase kinase-3 signaling in Alzheimer’s disease. BBA-Molecular Cell Res 1867:118664. https://doi.org/10.1016/j.bbamcr.2020.118664

Article  CAS  Google Scholar 

Pan J, Yao Q, Wang Y, Chang S, Li C, Wu Y, Shen J, Yang R (2024) The role of PI3K signaling pathway in Alzheimer’s disease. Front aging neurosci 16:1459025. https://doi.org/10.3389/fnagi.2024.1459025

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang H, Han Y, Zhang L, Jia X, Niu Q (2021) The GSK-3β/β-catenin signaling–mediated brain–derived neurotrophic factor pathway is involved in aluminum-induced impairment of hippocampal LTP in vivo. Biol Trace Elem Res 1:11. https://doi.org/10.1007/s12011-021-02582-9

Article  CAS  Google Scholar 

Rana AK, Kumar R, Shukla DN, Singh D (2023) Lithium co-administration with rutin improves post-stroke neurological outcomes via suppressing Gsk-3β activity in a rat model. Free Radic Biol Med 207:107–119. https://doi.org/10.1016/j.freeradbiomed.2023.07.004

Article  CAS  PubMed  Google Scholar 

Trott O, Olson AJ (2010) AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J Comput Chem 31:455–461. https://doi.org/10.1002/jcc.21334

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kumari S, Mazumder AG, Bhardwaj A, Singh D (2019) Early α-linole