Bertelli MO, Bianco A, Boniotti V (2025) Chaplin E. Definition, diagnosis, and prevalence of autism spectrum disorder. In The Palgrave Encyclopedia of Disability. Palgrave Macmillan, Cham, pp 1–15. https://doi.org/10.1007/978-3-031-40858-8_229-1

Chillarge GR, Deshpande RG, Tilak SR, Ahire SR, Kanaki N, Mehta PS, Sapkal SD, Rupnar V (2025) Early detection and prevention of autism spectrum disorder (ASD). In modern digital approaches to care technologies for individuals with disabilities. IGI Global Scientific Publishing, pp 325–346. https://doi.org/10.4018/979-8-3693-7560-0.ch017

Briot K, Jean F, Jouni A, Geoffray MM, Ly-Le Moal M, Umbricht D, Chatham C, Murtagh L, Delorme R, Bouvard M, Leboyer M (2020) Social anxiety in children and adolescents with autism spectrum disorders contribute to impairments in social communication and social motivation. Front Psychiatry 11:710. https://doi.org/10.3389/fpsyt.2020.00710

Article  PubMed  PubMed Central  Google Scholar 

Gómez-Campos R, Espinoza RV, Castro-Fuentes C, Flores-Vergara S, Gálvez-Zurita J, Urra-Albornoz C, De la Torre CC, Bolaños MC (2023) Comparison of social isolation in autistic children and adolescents according to age, marital status and number of siblings. Journal of Education and Health Promotion 1:316. https://doi.org/10.4103/jehp.jehp_1837_22

Article  Google Scholar 

Nadeem MS, Murtaza BN, Al-Ghamdi MA, Ali A, Zamzami MA, Khan JA, Ahmad A, Rehman MU, Kazmi I (2021) Autism-a comprehensive array of prominent signs and symptoms. Curr Pharm Des 27(11):1418–1433. https://doi.org/10.2174/1381612827666210120095829

Article  CAS  PubMed  Google Scholar 

Kentrou V, Livingston LA, Grove R, Hoekstra RA, Begeer S (2024) Perceived misdiagnosis of psychiatric conditions in autistic adults. EClinicalMedicine. https://doi.org/10.1016/j.eclinm.2024.102586

Article  PubMed  PubMed Central  Google Scholar 

Mao H, Cheng L, Zhang Y, Zhang F (2024) Gender differences in autism spectrum disorder: a systematic review of diagnosis, intervention, and outcomes. Gender and Sustainability in the Global South 1(1):92–136. https://doi.org/10.1515/gsgs-2024-0007

Article  Google Scholar 

Santomauro DF, Erskine HE, Herrera AM, Miller PA, Shadid J, Hagins H, Addo IY, Adnani QE et al (2025) The global epidemiology and health burden of the autism spectrum: findings from the Global Burden of Disease Study 2021. Lancet Psychiatry 12(2):111–121. https://doi.org/10.1016/S2215-0366(24)00363-8

Article  Google Scholar 

Álvarez-Couto M (2024) Challenging behaviors in adults with intellectual disabilities and ASD: related variables. In The Palgrave Encyclopedia of Disability, Cham: Springer Nature Switzerland, pp 1–12. https://doi.org/10.1007/978-3-031-40858-8_63-1

Singh R, Kisku A, Paramanik V, Kungumaraj HJ, Patel D, Kumar S, Sulakhiya K (2024) Recent updates on modifiable risk factors involved in the pathogenesis of autism spectrum disorders. J Biol Regul Homeost Agents 38:3605–3620. https://doi.org/10.23812/j.biol.regul.homeost.agents

Article  CAS  Google Scholar 

He Y, Xie K, Yang K, Wang N, Zhang L (2025) Unraveling the interplay between metabolism and neurodevelopment in health and disease. CNS Neurosci Ther 31(5):e70427. https://doi.org/10.1111/cns.70427

Article  CAS  PubMed  PubMed Central  Google Scholar 

Borrego-Ruiz A, Borrego JJ (2024) Neurodevelopmental disorders associated with gut microbiome dysbiosis in children. Children 11(7):796. https://doi.org/10.3390/children11070796

Article  PubMed  PubMed Central  Google Scholar 

Zarimeidani F, Rahmati R, Mostafavi M, Darvishi M, Khodadadi S, Mohammadi M, Shamlou F, Bakhtiyari S, Alipourfard I (2024) Gut microbiota and autism spectrum disorder: a neuroinflammatory mediated mechanism of pathogenesis? Inflammation 2:1–9. https://doi.org/10.1007/s10753-024-02061-y

Article  Google Scholar 

Afzaal M, Saeed F, Shah YA, Hussain M, Rabail R, Socol CT, Hassoun A, Pateiro M, Lorenzo JM, Rusu AV, Aadil RM (2022) Human gut microbiota in health and disease: unveiling the relationship. Front Microbiol 13:999001. https://doi.org/10.3389/fmicb.2022.999001

Article  PubMed  PubMed Central  Google Scholar 

Santacroce L, Man A, Haxhirexha K, Topi S (2021) Current knowledge about the connection between health status and gut microbiota from birth to elderly. A narrative review. Front Biosci 26(6):135–148

Article  CAS  Google Scholar 

Liu J, Tan Y, Cheng H, Zhang D, Feng W, Peng C (2022) Functions of gut microbiota metabolites, current status and future perspectives. Aging Dis 13(4):1106. https://doi.org/10.14336/AD.2022.0104

Article  PubMed  PubMed Central  Google Scholar 

Geng ZH, Zhu Y, Li QL, Zhao C, Zhou PH (2022) Enteric nervous system: the bridge between the gut microbiota and neurological disorders. Front Aging Neurosci 14:810483. https://doi.org/10.3389/fnagi.2022.810483

Article  CAS  PubMed  PubMed Central  Google Scholar 

Plaza-Diaz J, Radar AM, Baig AT, Leyba MF, Costabel MM, Zavala-Crichton JP, Sanchez-Martinez J, MacKenzie AE et al (2022) Physical activity, gut microbiota, and genetic background for children and adolescents with autism spectrum disorder. Children (Basel) 9(12):1834. https://doi.org/10.3390/children9121834

Article  PubMed  Google Scholar 

Zuffa S, Schimmel P, Gonzalez-Santana A, Belzer C, Knol J, Bölte S, Falck-Ytter T, Forssberg H, Swann J, Diaz Heijtz R (2023) Early-life differences in the gut microbiota composition and functionality of infants at elevated likelihood of developing autism spectrum disorder. Transl Psychiatry 13(1):257. https://doi.org/10.1038/s41398-023-02556-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Morton JT, Jin DM, Mills RH, Shao Y, Rahman G, McDonald D, Zhu Q, Balaban M, Jiang Y, Cantrell K, Gonzalez A (2023) Multi-level analysis of the gut–brain axis shows autism spectrum disorder-associated molecular and microbial profiles. Nat Neurosci 26(7):1208–1217. https://doi.org/10.1038/s41593-023-01361-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

Casimir P, Iwata R, Vanderhaeghen P (2024) Linking mitochondria metabolism, developmental timing, and human brain evolution. Curr Opin Genet Dev 86:102182. https://doi.org/10.1016/j.gde.2024.102182

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baev AY, Vinokurov AY, Potapova EV, Dunaev AV, Angelova PR, Abramov AY (2024) Mitochondrial permeability transition, cell death and neurodegeneration. Cells (Basel) 13(7):648. https://doi.org/10.3390/cells13070648

Article  CAS  Google Scholar 

Qiao L, Yang G, Wang P, Xu C (2024) The potential role of mitochondria in the microbiota-gut-brain axis: implications for brain health. Pharmacol Res. https://doi.org/10.1016/j.phrs.2024.107434

Article  PubMed  Google Scholar 

Rackham O, Filipovska A (2022) Organization and expression of the mammalian mitochondrial genome. Nat Rev Genet 23(10):606–623. https://doi.org/10.1038/s41576-022-00480-x

Article  CAS  PubMed  Google Scholar 

Sidenkova A (2023) Mitochondrial disorders and ASD. Mechanisms of mitochondrial dysfunction in ASD. Eur Psychiatry 66(S1):S100–S101. https://doi.org/10.1192/j.eurpsy.2023.285

Article  PubMed Central  Google Scholar 

Frye RE, Rincon N, McCarty PJ, Brister D, Scheck AC, Rossignol DA (2024) Biomarkers of mitochondrial dysfunction in autism spectrum disorder: a systematic review and meta-analysis. Neurobiol Dis. https://doi.org/10.1016/j.nbd.2024.106520

Article  PubMed  Google Scholar 

Mierau SB, Neumeyer AM (2019) Metabolic interventions in autism spectrum disorder. Neurobiol Dis 132:104544. https://doi.org/10.1016/j.nbd.2019.104544

Article  PubMed  Google Scholar 

Khaliulin I, Hamoudi W, Amal H (2025) The multifaceted role of mitochondria in autism spectrum disorder. Mol Psychiatry 30(2):629–650. https://doi.org/10.1038/s41380-024-02725-z

Article  CAS  PubMed  Google Scholar 

Su Q, Wong OW, Lu W, Wan Y, Zhang L, Xu W, Li MK, Liu C, Cheung CP, Ching JY, Cheong PK (2024) Multikingdom and functional gut microbiota markers for autism spectrum disorder. Nat Microbiol 9(9):2344–2355. https://doi.org/10.1038/s41564-024-01739-1

Article  CAS  PubMed  Google Scholar 

Ying J, Xu X, Zhou R, Chung AC, Ng SK, Fan X, Subramaniam M, Wong SH (2025) The gut microbiota in young adults with high-functioning autism spectrum disorder and its performance as diagnostic biomarkers. Nutrients 17(11):1748. https://doi.org/10.3390/nu17111748

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bhusri B, Sutheeworapong S, Kittichotirat W, Kusonmano K, Thammarongtham C, Lertampaiporn S, Prommeenate P, Praphanphoj V, Kittitharaphan W, Dulsawat S, Paenkaew P (2025) Characterization of gut microbiota on gender and age groups bias in Thai patients with autism spectrum disorder. Sci Rep 15(1):2587. https://doi.org/10.1038/s41598-025-86740-2