Joint United Nations Programme on HIV/AIDS (UNAIDS). Fact sheet 2023. Latest global and regional statistics on the status of the AIDS epidemic. 2021.
Hsu Y-C, Huang DQ, Nguyen MH. Global burden of hepatitis B virus: current status, missed opportunities and a call for action. Nat Rev Gastroenterol Hepatol. 2023;20:524–37.
Leumi S, Bigna JJ, Amougou MA, Ngouo A, Nyaga UF, Noubiap JJ. Global burden of hepatitis B infection in people living with human immunodeficiency virus: a systematic review and meta-analysis. Clin Infect Dis. 2020;71:2799–806.
Galle PR, Forner A, Llovet JM, Mazzaferro V, Piscaglia F, Raoul J-L, et al. EASL clinical practice guidelines: management of hepatocellular carcinoma. J Hepatol. 2018;69:182–236.
Chun HM, Roediger MP, Hullsiek KH, Thio CL, Agan BK, Bradley WP, et al. Hepatitis B virus coinfection negatively impacts HIV outcomes in HIV seroconverters. J Infect Dis. 2012;205:185–93.
Klein MB, Althoff KN, Jing Y, Lau B, Kitahata M, Lo Re V, et al. Risk of end-stage liver disease in HIV-viral hepatitis coinfected persons in North America from the early to modern antiretroviral therapy eras. Clin Infect Dis. 2016;63:1160–7.
Article PubMed PubMed Central Google Scholar
McMahon MA, Jilek BL, Brennan TP, Shen L, Zhou Y, Wind-Rotolo M, et al. The HBV drug entecavir—effects on HIV-1 replication and resistance. N Engl J Med. 2007;356:2614–21.
Article CAS PubMed PubMed Central Google Scholar
Sun S, Yang Q, Sheng Y, Fu Y, Sun C, Deng C. Investigational drugs with dual activity against HBV and HIV (review). Exp Ther Med. 2021;21:35.
Nassal M, Hepatitis B. Hepatitis B. viruses: Reverse transcription a different way. Virus Res. 2008;134:235–49.
Article CAS PubMed Google Scholar
Haines KM, Loeb DD. The sequence of the RNA primer and the DNA template influence the initiation of plus-strand DNA synthesis in hepatitis B virus. J Mol Biol. 2007;370:471–80.
Article CAS PubMed PubMed Central Google Scholar
Zhao X-L, Yang J-R, Lin S-Z, Ma H, Guo F, Yang R-F, et al. Serum viral duplex-linear DNA proportion increases with the progression of liver disease in patients infected with HBV. Gut. 2016;65:502–11.
Article CAS PubMed Google Scholar
Chemin I, Zoulim F. Hepatitis B virus induced hepatocellular carcinoma. Cancer Lett. 2009;286:52–9.
Article CAS PubMed Google Scholar
Bill CA, Summers J. Genomic DNA double-strand breaks are targets for hepadnaviral DNA integration. Proc Natl Acad Sci U S A. 2004;101:11135–40.
Article CAS PubMed PubMed Central Google Scholar
Tu T, Budzinska MA, Vondran FWR, Shackel NA, Urban S. Hepatitis B virus DNA integration occurs early in the viral life cycle in an in vitro infection model via sodium taurocholate cotransporting polypeptide-dependent uptake of enveloped virus particles. J Virol. 2018;92:e02007–17.
Article PubMed PubMed Central Google Scholar
Schröder ARW, Shinn P, Chen H, Berry C, Ecker JR, Bushman F. HIV-1 integration in the human genome favors active genes and local hotspots. Cell. 2002;110:521–9.
Strachan T. Human molecular genetics. 4th ed. New York: Garland Science; 2018.
Larsson SB, Tripodi G, Raimondo G, Saitta C, Norkrans G, Pollicino T, et al. Integration of hepatitis B virus DNA in chronically infected patients assessed by Alu-PCR. J Med Virol. 2018;90:1568–75.
Article CAS PubMed Google Scholar
Ramirez R, van Buuren N, Gamelin L, Soulette C, May L, Han D et al. Targeted Long-Read Sequencing Reveals Comprehensive Architecture, Burden, and Transcriptional Signatures from Hepatitis B Virus-Associated Integrations and Translocations in Hepatocellular Carcinoma Cell Lines. J Virol. 2021;95:e00299-21. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8428387/
van Buuren N, Ramirez R, Soulette C, Suri V, Han D, May L, et al. Targeted long-read sequencing reveals clonally expanded HBV-associated chromosomal translocations in patients with chronic hepatitis B. JHEP Rep. 2022;4:100449.
Article PubMed PubMed Central Google Scholar
Schneller D, Angel P. Cellular Origin of Hepatocellular Carcinoma. In: Tirnitz-Parker JEE, editor. Hepatocellular Carcinoma [Internet]. Brisbane (AU): Codon Publications; 2019. Available from: http://www.ncbi.nlm.nih.gov/books/NBK549196/
Ringlander J, Skoglund C, Prakash K, Andersson ME, Larsson SB, Tang K-W, et al. Deep sequencing of liver explant transcriptomes reveals extensive expression from integrated hepatitis B virus DNA. J Viral Hepat. 2020;27:1162–70.
Article CAS PubMed Google Scholar
Tu T, Mason WS, Clouston AD, Shackel NA, McCaughan GW, Yeh MM, et al. Clonal expansion of hepatocytes with a selective advantage occurs during all stages of chronic hepatitis B virus infection. J Viral Hepat. 2015;22:737–53. https://doi.org/10.1111/jvh.12380.
Article CAS PubMed Google Scholar
Budzinska MA, Shackel NA, Urban S, Tu T. Cellular genomic sites of hepatitis B virus DNA integration. Genes. 2018;9:365.
Article PubMed PubMed Central Google Scholar
Mason WS, Gill US, Litwin S, Zhou Y, Peri S, Pop O, et al. HBV DNA integration and clonal hepatocyte expansion in chronic hepatitis B patients considered immune tolerant. Gastroenterology. 2016;151:986–98.
Article CAS PubMed Google Scholar
Toh ST, Jin Y, Liu L, Wang J, Babrzadeh F, Gharizadeh B, et al. Deep sequencing of the hepatitis B virus in hepatocellular carcinoma patients reveals enriched integration events, structural alterations and sequence variations. Carcinogenesis. 2013;34:787–98.
Article CAS PubMed Google Scholar
Sung W-K, Zheng H, Li S, Chen R, Liu X, Li Y, et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet. 2012;44:765–9.
Article CAS PubMed Google Scholar
Zhao L-H, Liu X, Yan H-X, Li W-Y, Zeng X, Yang Y et al. Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun. 2016;7 :12992.
Yang L, Ye S, Zhao X, Ji L, Zhang Y, Zhou P, et al. Molecular characterization of HBV DNA integration in patients with hepatitis and hepatocellular carcinoma. J Cancer. 2018;9:3225–35.
Article PubMed PubMed Central Google Scholar
Sze KM-F, Ho DW-H, Chiu Y-T, Tsui Y-M, Chan L-K, Lee JM-F, et al. Hepatitis B Virus-Telomerase reverse transcriptase promoter integration harnesses host ELF4, resulting in telomerase reverse transcriptase gene transcription in hepatocellular carcinoma. Hepatol Baltim Md. 2021;73:23–40.
Li C-L, Hsu C-L, Lin Y-Y, Ho M-C, Hu, Chen C-L, et al. HBV DNA Integration into Telomerase or MLL4 Genes and TERT Promoter Point Mutation as Three Independent Signatures in Subgrouping HBV-Related HCC with Distinct Features. Liver Cancer. 2023;13:41–55. https://doi.org/10.1159/000530699.
Article CAS PubMed PubMed Central Google Scholar
Ding D, Lou X, Hua D, Yu W, Li L, Wang J, et al. Recurrent targeted genes of hepatitis B virus in the liver cancer genomes identified by a next-generation sequencing-based approach. PLoS Genet. 2012;8:e1003065.
Article CAS PubMed PubMed Central Google Scholar
Takubo K, Nakamura K-I, Izumiyama N, Furugori E, Sawabe M, Arai T, et al. Telomere shortening with aging in human liver. J Gerontol Biol Sci Med Sci. 2000;55:B533–6.
Dong H, Zhang L, Qian Z, Zhu X, Zhu G, Chen Y et al. Identification of HBV-MLL4 Integration and Its Molecular Basis in Chinese Hepatocellular Carcinoma. PloS One. 2015;10:e0123175. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406717/
Podlaha O, Wu G, Downie B, Ramamurthy R, Gaggar A, Subramanian M, et al. Genomic modeling of hepatitis B virus integration frequency in the human genome. PLoS One. 2019;14:e0220376. https://doi.org/10.1371/journal.pone.0220376.
Article CAS PubMed PubMed Central Google Scholar
Grudda T, Hwang HS, Taddese M, Quinn J, Sulkowski MS, Sterling RK, et al. Integrated hepatitis B virus DNA maintains surface antigen production during antiviral treatment. J Clin Invest. 2022;132(18):e161818.
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