Collaborators GH. Global, regional, and national burden of HIV/AIDS, 1990–2021, and forecasts to 2050, for 204 countries and territories: the global burden of disease study 2021. Lancet HIV. 2024;11(12):e807–22. https://doi.org/10.1016/S2352-3018(24)00212-1.

Article  Google Scholar 

Collaborators GBDHB. Global, regional, and national burden of hepatitis B, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Gastroenterol Hepatol. 2022;7(9):796–829. https://doi.org/10.1016/S2468-1253(22)00124-8.

Article  Google Scholar 

Leumi S, Bigna JJ, Amougou MA, Ngouo A, Nyaga UF, Noubiap JJ. Global burden of hepatitis B infection in people living with human immunodeficiency virus: a systematic review and meta-analysis. Clin Infect Dis. 2020;71(11):2799–806. https://doi.org/10.1093/cid/ciz1170.

Article  PubMed  Google Scholar 

Thio CL, Seaberg EC, Skolasky R Jr, Phair J, Visscher B, Munoz A, et al. HIV-1, hepatitis B virus, and risk of liver-related mortality in the Multicenter Cohort Study (MACS). Lancet. 2002;360(9349):1921–6. https://doi.org/10.1016/s0140-6736(02)11913-1.

Article  PubMed  Google Scholar 

Sun J, Althoff KN, Jing Y, Horberg MA, Buchacz K, Gill MJ, et al. Trends in hepatocellular carcinoma incidence and risk among persons with HIV in the US and Canada, 1996–2015. JAMA Netw Open. 2021;4(2):e2037512. https://doi.org/10.1001/jamanetworkopen.2020.37512.

Article  PubMed  PubMed Central  Google Scholar 

Colin JF, Cazals-Hatem D, Loriot MA, Martinot-Peignoux M, Pham BN, Auperin A, et al. Influence of human immunodeficiency virus infection on chronic hepatitis B in homosexual men. Hepatology. 1999;29(4):1306–10. https://doi.org/10.1002/hep.510290447.

Article  CAS  PubMed  Google Scholar 

Guidelines for the use of antiretroviral agents in adults and adolescents with HIV. 2024. https://clinicalinfo.hiv.gov/en/guidelines/adult-and-adolescent-arv. Accessed Aug 5 2025.

Chan HL, Tse CH, Mo F, Koh J, Wong VW, Wong GL, et al. High viral load and hepatitis B virus subgenotype ce are associated with increased risk of hepatocellular carcinoma. J Clin Oncol. 2008;26(2):177–82. https://doi.org/10.1200/JCO.2007.13.2043.

Article  CAS  PubMed  Google Scholar 

Hosaka T, Suzuki F, Kobayashi M, Seko Y, Kawamura Y, Sezaki H, et al. Long-term entecavir treatment reduces hepatocellular carcinoma incidence in patients with hepatitis B virus infection. Hepatology. 2013;58(1):98–107. https://doi.org/10.1002/hep.26180.

Article  CAS  PubMed  Google Scholar 

Marcellin P, Gane E, Buti M, Afdhal N, Sievert W, Jacobson IM, et al. Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study. Lancet. 2013;381(9865):468–75. https://doi.org/10.1016/S0140-6736(12)61425-1.

Article  CAS  PubMed  Google Scholar 

Kim HN, Newcomb CW, Carbonari DM, Roy JA, Torgersen J, Althoff KN, et al. Risk of HCC with hepatitis B viremia among HIV/HBV-coinfected persons in North America. Hepatology. 2021;74(3):1190–202. https://doi.org/10.1002/hep.31839.

Article  CAS  PubMed  Google Scholar 

Sterling RK, King WC, Khalili M, Chung RT, Sulkowski M, Jain MK, et al. A prospective study evaluating changes in histology, clinical and virologic outcomes in HBV-HIV co-infected adults in North America. Hepatology. 2021;74(3):1174–89. https://doi.org/10.1002/hep.31823.

Article  CAS  PubMed  Google Scholar 

Lo Re V, Justice AC, Taddei TH, Roy JA, Brown ST, Bräu N, et al. HIV RNA, CD4+ percentage, and risk of hepatocellular carcinoma by cirrhosis status. JNCI: J Natl Cancer Inst. 2020;112(7):747–55. https://doi.org/10.1093/jnci/djz214.

Article  CAS  PubMed  Google Scholar 

Prevention and management of hepatitis B virus infection in adults with HIV. 2022. https://www.hivguidelines.org/guideline/hiv-hbv/. Accessed 10 Oct 2024.

Guidelines for the prevention, diagnosis, care and treatment for people with chronic hepatitis B infection. Geneva: World Health Organization; 2024.

European Association for the Study of the L. EASL Clinical Practice Guidelines on the management of hepatitis B virus infection. J Hepatol. 2025;83(2):502–83. https://doi.org/10.1016/j.jhep.2025.03.018.

Article  Google Scholar 

Omata M, Cheng AL, Kokudo N, Kudo M, Lee JM, Jia J, et al. Asia-Pacific clinical practice guidelines on the management of hepatocellular carcinoma: a 2017 update. Hepatol Int. 2017;11(4):317–70. https://doi.org/10.1007/s12072-017-9799-9.

Article  PubMed  Google Scholar 

Singal AG, Llovet JM, Yarchoan M, Mehta N, Heimbach JK, Dawson LA, et al. Aasld practice guidance on prevention, diagnosis, and treatment of hepatocellular carcinoma. Hepatology. 2023;78(6):1922–65. https://doi.org/10.1097/HEP.0000000000000466.

Article  PubMed  Google Scholar 

Cheraghpour M, Hatami B,Singal AG. Lifestyle and pharmacologic approaches to prevention of metabolic dysfunction-associated steatotic liver disease-related hepatocellular carcinoma. Clin Gastroenterol Hepatol. 2025;23(5):685–94 e6. https://doi.org/10.1016/j.cgh.2024.09.041.

European Association for the Study of the Liver. EASL clinical practice guidelines: management of hepatocellular carcinoma. J Hepatol. 2018;69(1):182–236. https://doi.org/10.1016/j.jhep.2018.03.019.

Article  Google Scholar 

Frenette CT, Isaacson AJ, Bargellini I, Saab S, Singal AG. A practical guideline for hepatocellular carcinoma screening in patients at risk. Mayo Clin Proc: Innov Qual Outcomes. 2019;3(3):302–10. https://doi.org/10.1016/j.mayocpiqo.2019.04.005.

Article  PubMed  Google Scholar 

Papatheodoridis G, Dalekos G, Sypsa V, Yurdaydin C, Buti M, Goulis J, et al. PAGE-B predicts the risk of developing hepatocellular carcinoma in Caucasians with chronic hepatitis B on 5-year antiviral therapy. J Hepatol. 2016;64(4):800–6. https://doi.org/10.1016/j.jhep.2015.11.035.

Article  CAS  PubMed  Google Scholar 

Surial B, Ramirez Mena A, Roumet M, Limacher A, Smit C, Leleux O, et al. External validation of the PAGE-B score for HCC risk prediction in people living with HIV/HBV coinfection. J Hepatol. 2023;78(5):947–57. https://doi.org/10.1016/j.jhep.2022.12.029.

Article  PubMed  Google Scholar 

Gokcen P, Guzelbulut F, Adali G, Degirmenci Salturk AG, Ozturk O, Bahadir O, et al. Validation of the PAGE-B score to predict hepatocellular carcinoma risk in Caucasian chronic hepatitis B patients on treatment. World J Gastroenterol. 2022;28(6):665–74. https://doi.org/10.3748/wjg.v28.i6.665.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Voulgaris T, Papatheodoridi M, Lampertico P, Papatheodoridis GV. Clinical utility of hepatocellular carcinoma risk scores in chronic hepatitis B. Liver Int. 2020;40(3):484–95. https://doi.org/10.1111/liv.14334.

Article  PubMed  Google Scholar 

Wandeler G, Mauron E, Atkinson A, Dufour JF, Kraus D, Reiss P, et al. Incidence of hepatocellular carcinoma in HIV/HBV-coinfected patients on tenofovir therapy: relevance for screening strategies. J Hepatol. 2019;71(2):274–80. https://doi.org/10.1016/j.jhep.2019.03.032.

Article  CAS  PubMed  Google Scholar 

Sparchez Z, Craciun R, Caraiani C, Horhat A, Nenu I, Procopet B, et al. Ultrasound or sectional imaging techniques as screening tools for hepatocellular carcinoma: fall forward or move forward? J Clin Med. 2021. https://doi.org/10.3390/jcm10050903.

Singal AG, Tayob N, Mehta A, Marrero JA, El-Serag H, Jin Q, et al. Galad demonstrates high sensitivity for HCC surveillance in a cohort of patients with cirrhosis. Hepatology. 2022;75(3):541–9. https://doi.org/10.1002/hep.32185.

Article  CAS  PubMed  Google Scholar 

Yu X, Lei X. Application of the multi-omics liquid biopsy method M2P-HCC in early liver cancer screening for high-risk individuals with hepatitis B-related liver cancer. Diagnostics. 2023;13(15):2484. https://doi.org/10.3390/diagnostics13152484.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tzartzeva K, Obi J, Rich NE, Parikh ND, Marrero JA, Yopp A, et al. Surveillance imaging and alpha fetoprotein for early detection of hepatocellular carcinoma in patients with cirrhosis: a meta-analysis. Gastroenterology. 2018;154(6):1706-18 e1. https://doi.org/10.1053/j.gastro.2018.01.064.

Article  CAS  PubMed  Google Scholar 

Roberts LR, Sirlin CB, Zaiem F, Almasri J, Prokop LJ, Heimbach JK, et al. Imaging for the diagnosis of hepatocellular carcinoma: a systematic review and meta-analysis. Hepatology. 2018;67(1):401–21. https://doi.org/10.1002/hep.29487.

Article  PubMed  Google Scholar 

Obajimi MO, Atalabi MO, Ogbole GI, Adeniji-Sofoluwe AT, Agunloye AM, Adekanmi AJ, et al. Abdominal ultrasonography in HIV/AIDS patients in southwestern Nigeria. BMC Med Imaging. 2008;8:5. https://doi.org/10.1186/1471-2342-8-5.

Article  PubMed  PubMed Central  Google Scholar 

Merchante N, Figueruela B, Rodriguez-Fernandez M, Rodriguez-Arrondo F, Revollo B, Ibarra S, et al. Low performance of ultrasound surveillance for the diagnosis of hepatocellular carcinoma in HIV-infected patients. AIDS. 2019;33(2):269–78. https://doi.org/10.1097/QAD.0000000000002065.