Age-related changes in adrenergic regulation of contractility and redox status of glycolytic and oxidative skeletal muscles

Wiedmer P, Jung T, Castro JP, Pomatto LCD, Sun PY, Davies KJA, et al. Sarcopenia - molecular mechanisms and open questions. Ageing Res Rev. 2021;65:101200.

Article  CAS  PubMed  Google Scholar 

Clark BC, Manini TM. Sarcopenia =/= dynapenia. J Gerontol A Biol Sci Med Sci. 2008;63:829–34.

Article  PubMed  Google Scholar 

Xu H, Brown JL, Bhaskaran S, Van Remmen H. Reactive oxygen species in the pathogenesis of sarcopenia. Free Radic Biol Med. 2025;227:446–58.

Article  CAS  PubMed  Google Scholar 

Nishikawa H, Fukunishi S, Asai A, Yokohama K, Nishiguchi S, Higuchi K. Pathophysiology and mechanisms of primary sarcopenia (review). Int J Mol Med. 2021;48:156. https://doi.org/10.3892/ijmm.2021.4989.

Blackwood SJ, Katz A. Isoproterenol enhances force production in mouse glycolytic and oxidative muscle via separate mechanisms. Pflugers Arch. 2019;471:1305–16.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Morris SR, Gittings W, Vandenboom R. Epinephrine augments posttetanic potentiation in mouse skeletal muscle with and without myosin phosphorylation. Physiol Rep. 2018;6:e13690.

Article  PubMed  PubMed Central  Google Scholar 

Cairns SP, Dulhunty AF. The effects of beta-adrenoceptor activation on contraction in isolated fast- and slow-twitch skeletal muscle fibres of the rat. Br J Pharmacol. 1993;110:1133–41.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Holmberg E, Waldeck B. Analysis of the beta-receptor mediated effect on fast-contracting skeletal muscle in vitro. Naunyn Schmiedebergs Arch Pharmacol. 1977;301:109–13.

Article  CAS  PubMed  Google Scholar 

Abdalla-Silva RL, Zanetti GO, Lautherbach N, Schavinski AZ, Heck LC, Goncalves DAP, et al. Beta(2)-adrenoceptors activation regulates muscle trophic-related genes following acute resistance exercise in mice. Front Physiol. 2024;15:1268380.

Article  PubMed  PubMed Central  Google Scholar 

Navegantes LC, Resano NM, Migliorini RH, Kettelhut IC. Role of adrenoceptors and cAMP on the catecholamine-induced inhibition of proteolysis in rat skeletal muscle. Am J Physiol Endocrinol Metab. 2000;279:E663-668.

Article  CAS  PubMed  Google Scholar 

Cairns SP, Borrani F. beta-Adrenergic modulation of skeletal muscle contraction: key role of excitation-contraction coupling. J Physiol. 2015;593:4713–27.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lynch GS, Ryall JG. Role of beta-adrenoceptor signaling in skeletal muscle: implications for muscle wasting and disease. Physiol Rev. 2008;88:729–67.

Article  CAS  PubMed  Google Scholar 

Delbono O, Rodrigues ACZ, Bonilla HJ, Messi ML. The emerging role of the sympathetic nervous system in skeletal muscle motor innervation and sarcopenia. Ageing Res Rev. 2021;67:101305.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yuan S, Zheng S, Zheng K, Gao Y, Chen M, Li Y, et al. Sympathetic activity is correlated with satellite cell aging and myogenesis via beta2-adrenoceptor. Stem Cell Res Ther. 2021;12:505.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hotta H, Iimura K, Watanabe N, Suzuki H, Sugie M, Shigemoto K. Sympathetic modulation of hindlimb muscle contractility is altered in aged rats. Sci Rep. 2023;13:7504.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rodrigues ACZ, Messi ML, Wang ZM, Bonilla HJ, Freeman WM, Delbono O. Long-term, induced expression of Hand2 in peripheral sympathetic neurons ameliorates sarcopenia in geriatric mice. J Cachexia Sarcopenia Muscle. 2021;12:1908–24.

Article  PubMed  PubMed Central  Google Scholar 

Ryall JG, Plant DR, Gregorevic P, Sillence MN, Lynch GS. Beta 2-agonist administration reverses muscle wasting and improves muscle function in aged rats. J Physiol. 2004;555:175–88.

Article  CAS  PubMed  Google Scholar 

Gonçalves DA, Silveira WA, Manfredi LH, Graça FA, Armani A, Bertaggia E, O´ Neill BT, Lautherbach N, Machado J, Nogara L, Pereira MG. Insulin/IGF1 signalling mediates the effects of β2‐adrenergic agonist on muscle proteostasis and growth. Journal of cachexia, sarcopenia and muscle. 2019 10(2):455-75.

Dutt V, Gupta S, Dabur R, Injeti E, Mittal A. Skeletal muscle atrophy: potential therapeutic agents and their mechanisms of action. Pharmacol Res. 2015;99:86–100.

Article  CAS  PubMed  Google Scholar 

Ryall JG, Schertzer JD, Alabakis TM, Gehrig SM, Plant DR, Lynch GS. Intramuscular beta2-agonist administration enhances early regeneration and functional repair in rat skeletal muscle after myotoxic injury. J Appl Physiol (1985). 2008;105:165–72.

Article  CAS  PubMed  Google Scholar 

Ryall JG, Schertzer JD, Lynch GS. Attenuation of age-related muscle wasting and weakness in rats after formoterol treatment: therapeutic implications for sarcopenia. J Gerontol A Biol Sci Med Sci. 2007;62:813–23.

Article  PubMed  Google Scholar 

Higashihara T, Nishi H, Takemura K, Watanabe H, Maruyama T, Inagi R, et al. Beta2-adrenergic receptor agonist counteracts skeletal muscle atrophy and oxidative stress in uremic mice. Sci Rep. 2021;11:9130.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nilwik R, Snijders T, Leenders M, Groen BB, van Kranenburg J, Verdijk LB, et al. The decline in skeletal muscle mass with aging is mainly attributed to a reduction in type II muscle fiber size. Exp Gerontol. 2013;48:492–8.

Article  PubMed  Google Scholar 

Lexell J, Human aging, muscle mass, and fiber type composition, J Gerontol A Biol Sci Med Sci, 50 Spec No (1995) 11–16.

Short KR, Vittone JL, Bigelow ML, Proctor DN, Coenen-Schimke JM, Rys P, et al. Changes in myosin heavy chain mRNA and protein expression in human skeletal muscle with age and endurance exercise training. J Appl Physiol. 2005;99(1):95–102.

Article  CAS  PubMed  Google Scholar 

Zhang FM, Wu HF, Wang KF, Yu DY, Zhang XZ, Ren Q, et al. Transcriptome profiling of fast/glycolytic and slow/oxidative muscle fibers in aging and obesity. Cell Death Dis. 2024;15:459.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barontini M, Lazzari JO, Levin G, Armando I, Basso SJ. Age-related changes in sympathetic activity: biochemical measurements and target organ responses. Arch Gerontol Geriatr. 1997;25:175–86.

Article  CAS  PubMed  Google Scholar 

Hotta H, Uchida S. Aging of the autonomic nervous system and possible improvements in autonomic activity using somatic afferent stimulation. Geriatr Gerontol Int. 2010;10(Suppl 1):S127-136.

PubMed  Google Scholar 

Seals DR, Esler MD. Human ageing and the sympathoadrenal system. J Physiol. 2000;528:407–17.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Esler M, Lambert G, Kaye D, Rumantir M, Hastings J, Seals DR. Influence of ageing on the sympathetic nervous system and adrenal medulla at rest and during stress. Biogerontology. 2002;3:45–9.

Article  CAS  PubMed  Google Scholar 

Minchew EC, Williamson NC, Readyoff AT, McClung JM, Spangenburg EE. Isometric skeletal muscle contractile properties in common strains of male laboratory mice. Front Physiol. 2022;13:937132.

Article  PubMed  PubMed Central  Google Scholar 

Tsentsevitsky AN, Sibgatullina GV, Odoshivkina YG, Khuzakhmetova VF, Tokmakova AR, Ponomareva AA. Functional and structural changes in diaphragm neuromuscular junctions in early aging. Int J Mol Sci. 2024;25:8959. https://doi.org/10.3390/ijms25168959.

Odnoshivkina UG, Sytchev VI, Nurullin LF, Giniatullin AR, Zefirov AL, Petrov AM. Β2-adrenoceptor agonist-evoked reactive oxygen species generation in mouse atria: implication in delayed inotropic effect. Eur J Pharmacol. 2015;765:140–53.

Article  CAS  PubMed 

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