PI3Kγ-targeted inhibitor

Machine learning

Molecular hybridization

Indole-hybrid aromatic ring

PI3K/AKT/NF-κB signaling axis

Tumor-associated macrophage reprograming

Immunomodulation

Melanoma treatment

computer-aided drug design

cyclin-dependent kinases

cytotoxic T lymphocyte associate protein-4

cellular thermal shift assay

dulbecco's modified eagle medium

4',6-diamidino-2-phenylindole

2',7'-dichlorodihydrofluorescein diacetate

3,3-diaminobenzidine-tetrachloride

enzyme-linked immunosorbent assay

enhanced chemiluminescence

extended connectivity fingerprints

fluorescein isothiocyanate

globe online structure-activity relationship database

indole-hybrid aromatic ring

inhibitor of kappa B kinase

kyoto encyclopedia of genes and genomes

mammalian target of rapamycin

3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyl tetrazolium bromide methyl thiazolyl tetrazolium

nuclear factor kappa-B

programmed cell death ligand 1

programmed death receptor 1

phosphoinositide 3-kinase

phosphate buffer saline

poly adp-ribose polymerase

polyvinylidene difluoride

reactive oxygen species

receiver operating characteristic

root-mean-square deviation

radioimmunoprecipitation assay buffer

support vector machine

sodium dodecyl sulfate-polyacrylamide gel electrophoresis

tumor necrosis factor-α

tumor necrosis factor-α.

tumor-associated macrophages

M1-type tumor-associated macrophages

M2-type tumor-associated macrophage

t-distributed stochastic neighbor embedding

terminal deoxynucleotidyl transferase