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Inhalable songorine-integrated lipid nanomedicine for targeted ARDS therapy via repairing endothelial barrier and inactivating NLRP3 inflammasome
Available online 4 November 2025Author links open overlay panel, , , , , , , , , , , AbstractAcute respiratory distress sy...
Cuproptosis-based nanomedicine in cancer metastasis synergistic therapy
Available online 5 November 2025Author links open overlay panel, , , , , , , , , , AbstractCancer metastasis is a critical...
Lipid-based nanosystems for atherosclerosis treatment: Evolving approaches and novel therapeutic strategies
Available online 5 November 2025Author links open overlay panel, , , , , , , , , , , AbstractAtherosclerosis, the leading ...
pH-Activatable engineered nanoparticle-based selective hexokinase 2 degrader provokes GSDME-dependent pyroptosis for cancer therapy
Available online 5 November 2025Author links open overlay panel, , , , , , , , , AbstractProteolysis targeting chimeras (P...
Vitamin A and its analogues modulate MUFAs metabolism to improve ferroptosis and aging by direct targeting of ACSL3
In our screening campaign for novel ferroptosis inhibitors, we identified that vitamin A (VA) and its metabolite all-trans...
A novel machine learning framework-based rapid screening of ionizable lipids in LNPs for highly-efficient mRNA expression
Available online 7 November 2025Author links open overlay panel, , , , , , , , , , , , , , , , , , AbstractIonizable lipid...
Antibody‒drug conjugates with DHODH inhibitor as novel payload class for cancer and SARS-CoV-2 infection therapies
Available online 12 November 2025Author links open overlay panel, , , , , , , , , , , , , AbstractDespite remarkable achie...
Carboxylated prodrug of capsaicin with enhanced peripheral nerve permeation mediated by monocarboxylate transporters for long-lasting local anesthesia
Available online 12 November 2025Author links open overlay panel, , , , , , , , , AbstractPerineurally injected nerve-bloc...
Engineered bacterial extracellular vesicles mediate pyroptosis to counteract m6A methylation-based immunosuppression after insufficient radiofrequency ablation of hepatocellular carcinoma
Available online 12 November 2025Author links open overlay panel, , , , , , , , , , , , , , , , AbstractInsufficient radio...
An immunostimulant nanomedicine enhances radioimmunotherapy by remodeling the tumor immunosuppressive landscape after radiotherapy
Available online 13 November 2025Author links open overlay panel, , , , , , , AbstractStudies have shown that radiotherapy...
USP10-mediated deubiquitination and activation of KRAS mutants promotes colorectal cancer via a novel USP10/KRAS positive feedback circuit
Available online 13 November 2025Author links open overlay panel, , , , , , , , , , , , , , AbstractKirsten rat sarcoma vi...
Structural biology of HIV-1 reverse transcriptase allosteric inhibitors for drug design
Available online 13 November 2025Author links open overlay panel, , , , , , , , AbstractHIV-1 reverse transcriptase (RT) i...
Cold exposure-induced β-hydroxybutyrate promotes brown fat mitochondrial lipid droplet contact to ameliorate fatty dysfunction and hepatic steatosis
Available online 13 November 2025Author links open overlay panel, , , , , , , , , , , , , , , , AbstractCold exposure acti...
Chinese medicine and intermittent fasting integration therapy attenuate diabetic vascular calcification via miR21-5p/Tpm1-mediated osteogenic differentiation of VSMCs
Available online 13 November 2025Author links open overlay panel, , , , , , AbstractVascular calcification (VC) is a marke...
Extracellular vesicles-derived hybrid biomimetic nanoplatforms camouflaged Golgi apparatus-targeted aggregation induced emission photosensitizer to elicit pyroptosis and immunogenic cell death for efficient antitumor photoimmunotherapy
Available online 13 November 2025Author links open overlay panel, , , , , AbstractPyroptosis is a unique programmed cell d...
Dichotomous role of CD47–SIRPα axis: leveraging opposing functions in phagocytic resistance and transport assistance for enhanced nanocarrier biocompatibility and tumor penetration
Available online 13 November 2025Author links open overlay panel, , , , , , , , , AbstractPolyethylene glycol (PEG) carrie...
Biomimetic nitric oxide nanogenerators for synergistic gas-mild photothermal therapy of large solid tumor
Available online 13 November 2025Author links open overlay panel, , , , , AbstractThe mild photothermal therapy of solid t...
Engineering selective PI3Kγ inhibitors with antitumor and immunomodulatory potentials
KEY WORDSPI3Kγ-targeted inhibitorMachine learningMolecular hybridizationIndole-hybrid aromatic ringPI3K/AKT/NF-κB signalin...
Leveraging large language models to analyze solid dosage disintegration images
Available online 14 November 2025Author links open overlay panel, , , , AbstractDisintegration kinetics and behavior can a...
An integrated resource for ischemic heart disease defines hallmarks and heterogeneity across time and space
Available online 14 November 2025Author links open overlay panel, , , , , , , , , , , , , KeywordsIschemic heart diseaseSi...
Modified probiotics and the related combinatorial therapeutics
Available online 14 March 2025Author links open overlay panel, , , , , , , , , AbstractProbiotics have shown excellent app...
VenusMutHub: A systematic evaluation of protein mutation effect predictors on small-scale experimental data
Available online 14 March 2025Author links open overlay panel, , , , , , , , , , , , , AbstractIn protein engineering, whi...
Inhibition of CCT5-mediated asparagine biosynthesis and anti-PD-L1 produce synergistic antitumor effects in colorectal cancer
Available online 14 March 2025Author links open overlay panel, , , , , , , , , , AbstractAbnormal amino acid metabolism pr...
A chemotherapy nano-booster unlocks wider therapeutic window for prostate cancer treatment
Available online 14 March 2025Author links open overlay panel, , , , , , , , , AbstractClinical chemotherapy for prostate ...
Phenotypic plasticity and secretory heterogeneity in subpopulations derived from single cancer cell
Available online 15 March 2025Author links open overlay panel, , , , , , , , AbstractSingle-cell analysis of phenotypic pl...
Mechanism of Alzheimer's disease treatment by sound and light stimulation
Available online 15 March 2025Author links open overlay panel, , Key wordsAβMultisensory stimulationLymphatic drainageAlzh...
A cisplatin prodrug-based self-assembling ozone delivery nanosystem sensitizes radiotherapy in triple-negative breast cancer
Available online 17 March 2025Author links open overlay panel, , , , , , , , , , , , , AbstractLacking therapeutic targets...
Imaging the impact of sex and age on OATP function in humans: consequences for whole-body pharmacokinetics and liver exposure
Organic anion-transporting polypeptides (OATP) transporter function, which mediates many drugs' liver uptake, was investig...
Celastrol-loaded ginsenoside Rg3 liposomes boost immunotherapy by remodeling obesity-related immunosuppressive tumor microenvironment in melanoma
Available online 17 March 2025Author links open overlay panel, , , , , , , , , , AbstractObesity usually exacerbates the i...
SMAD4 depletion enhances NHEJ by regulating BRCA1 expression through ARIH1 in pancreatic cancer
Available online 18 March 2025Author links open overlay panel, , , , , , , , Key wordsSMAD4BRCA1Pancreatic cancerNon-homol...
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