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Potential therapeutic mechanisms of Draconis Resina in cardiovascular diseases-a narrative review
1 IntroductionCardiovascular disease, recognized as the leading cause of mortality threatening human health, is a focus of...
Editorial: Cellular and molecular mechanisms in metabolic disorders: role of inflammation and oxidative stress
Metabolic disorders, including diabetes, obesity, and chronic kidney disease (CKD), remain leading contributors to global ...
Histone deacetylases: the critical enzymes for microglial activation involved in neuropathic pain
1 IntroductionThe definition of neuropathic pain has been developed over the past 30 years. In 1994, International Associa...
World no-tobacco: effects of second-hand smoke (SHS) and vapors on the developing and adult brain
1 IntroductionPlease see Figure 1 for the Prisma statement. Figure 1. The number of records identified from the PubMed d...
Clinical implications of fracture severity risk with pioglitazone: a systematic review and meta-analysis of clinical randomized trials
1 IntroductionStroke survivors face a significantly elevated risk of falls and the associated risk of fractures (Batchelor...
Case report: Effectiveness of Janus kinase inhibitors in the management of isolated noninfectious uveitis: a case series
1 IntroductionUveitis refers to inflammation of the uvea, which includes the iris, ciliary body, and choroid; however, it ...
Targeting miRNA with flavonoids: unlocking novel pathways in cardiovascular disease management
1 IntroductionCardiovascular disease (CVD) encompasses a range of heart and blood vessel disorders that are the leading ca...
Adverse event profile of lomustine and temozolomide: a descriptive analysis from WHO-VigiAccess
IntroductionGlioma is the most prevalent primary intracranial tumor, accounting for approximately 30% of all brain and cen...
Selenium reduces oxaliplatin induced neuropathic pain: focus on TRPV1
IntroductionOxaliplatin is a widely used first-line chemotherapy agent for many types of tumors, including colorectal carc...
Apigenin protects ischemic stroke by regulating intestinal microbiota homeostasis, regulates brain metabolic profile
1 IntroductionStroke is a leading cause of death and disability, affecting nearly 100 million people worldwide (Carcel et ...
Pharmacophore screening, molecular docking, and MD simulations for identification of VEGFR-2 and c-Met potential dual inhibitors
1 IntroductionCancer poses a significant challenge to society, public health, and global economies in the current century....
Paeonol ameliorates ferroptosis and inflammation in chondrocytes through AMPK/Nrf2/GPX4 pathway
IntroductionKnee osteoarthritis (KOA) is a common degenerative joint disease. Osteoarthritis affects approximately 7% of t...
Clinical–pharmaceutical assessment of medication CDSS alerts: content appropriateness and patient relevance in clinical practice
1 IntroductionOver the last 2 decades and since “To Err is Human” was published, several concepts (e.g., clinical pharmacy...
An integrative pharmacology-based study on the pharmacological activity and mechanism of xiaoji-chenpi formula (XCF) against MAFLD
1 IntroductionNonalcoholic fatty liver disease (NAFLD), renamed metabolic-associated fatty liver disease (MAFLD), has beco...
Therapeutic modulation of protein RBM3 for ischemic stroke treatment
1 IntroductionIschemic stroke occurs due to insufficient blood flow to cerebral tissue, leading to irreversible damage and...
Efficacy and safety of conventional disease-modifying antirheumatic drugs in VEXAS syndrome: real-world data from the international AIDA network
Highlights• Given the absence of standardized treatment guidelines for VEXAS syndrome, this study provides preliminary evi...
Editorial: Machine learning advancements in pharmacology: transforming drug discovery and healthcare
In recent years, the integration of machine learning (ML) into pharmacology has revolutionized how we approach drug discov...
Medication nonadherence - definition, measurement, prevalence, and causes: reflecting on the past 20 years and looking forwards
1 IntroductionThe landmark 2003 World Health Organisation medication nonadherence report (Sabaté, 2003) begins with discus...
Effects of Tanreqing injection against ventilator-associated pneumonia: a meta-analysis and systematic review of clinical studies
1 IntroductionVentilator-associated pneumonia (VAP) is a type of nosocomial pneumonia that develops after a minimum of 48 ...
α-Bisabolol alleviates doxorubicin-induced cognitive dysfunction in rats via enhancing the hippocampal BDNF/TrKB signaling and inhibiting neuroinflammation
1 IntroductionCancer chemotherapy is usually associated with a wide range of devastating side effects that seriously impai...
Editorial: Disease-on-a-chip: from point-of-care to personalized medicine
Editorial: Disease-on-a-chip: from point-of-care to personalized medicine
Miniaturization has played a pivotal role in driving innovation in microfluidic devices, particularly in their application...
Phase-specific differential regulation of mechanical allodynia in a murine model of neuropathic pain by progesterone
Phase-specific differential regulation of mechanical allodynia in a murine model of neuropathic pain by progesterone
Progesterone has been shown to have neuroprotective capabilities against a wide range of nervous system injuries, however ...
Drug repositioning in thyroid cancer treatment: the intriguing case of anti-diabetic drugs
Drug repositioning in thyroid cancer treatment: the intriguing case of anti-diabetic drugs
Cancer represents the main cause of death worldwide. Thyroid cancer (TC) shows an overall good rate of survival, however t...
Research hotspots and trend analysis of cell transplantation in traumatic spinal cord injury: a bibliometric and visualized analysis
Research hotspots and trend analysis of cell transplantation in traumatic spinal cord injury: a bibliometric and visualized analysis
Background: A traumatic spinal cord injury (TSCI) can lead to severe nerve damage and disability. Cell transplantation the...
From the CONSORT to the ConPhyMP statement and beyond—how to ascertain best practice
From the CONSORT to the ConPhyMP statement and beyond—how to ascertain best practice
With the implementation of the ConPhyMP reporting tool as an element of peer review in Frontiers in Pharmacology, Section ...
A phase I study to evaluate the safety, tolerability, and pharmacokinetics of a novel, potent GABA analog HSK16149 in healthy Chinese subjects
A phase I study to evaluate the safety, tolerability, and pharmacokinetics of a novel, potent GABA analog HSK16149 in healthy Chinese subjects
Purpose: HSK16149 is a novel, potent gamma-aminobutyric acid (GABA) analog for the treatment of neuropathic pain. This stu...
Psoriasis comorbid with atherosclerosis meets in lipid metabolism
Psoriasis comorbid with atherosclerosis meets in lipid metabolism
Psoriasis (PSO) is a common skin disease affecting approximately 1%–3% of the population, and the incidence rate is increa...
Case report: SAF-189s is a potent inhibitor in a lorlatinib-resistant NSCLC patient with acquired compound mutations ALK L1196M and D1203N
Case report: SAF-189s is a potent inhibitor in a lorlatinib-resistant NSCLC patient with acquired compound mutations ALK L1196M and D1203N
Acquired anaplastic lymphoma kinase (ALK) mutation is the major resistant mechanism to ALK tyrosine kinase inhibitors (TKI...
Herbal formulas for detoxification and dredging collaterals in treating carotid atherosclerosis: a systematic review and meta-analysis
Herbal formulas for detoxification and dredging collaterals in treating carotid atherosclerosis: a systematic review and meta-analysis
Objective: To systematically evaluate the efficacy and safety of the Chinese medicine detoxification and dredging collater...
Physical activity influences adherence to pharmacological treatments in patients with severe mental disorders: results from the multicentric, randomized controlled LIFESTYLE trial
Physical activity influences adherence to pharmacological treatments in patients with severe mental disorders: results from the multicentric, randomized controlled LIFESTYLE trial
Introduction: Poor adherence to pharmacological treatment is frequent in people with severe mental disorders and it often ...
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