Prof. Dr. Lei Huang (ORCiD: https://orcid.org/0000–0002–4225–9200), Principal Investigator leading the "Digestive Inflammation-Cancer Transformation and Precision Diagnosis and Treatment" research group at the National Clinical Research Center for Digestive Diseases and National Key Laboratory of Immunity and Inflammation, is a distinguished expert in digestive oncology and digestive diseases (translational research, precision medicine, epidemiology, and clinical trials) and a "World's TOP 2% Scientist" according to ELSEVIER and Stanford University, with research foci encompassing: (A) mechanisms, interventions, and precision prediction of gastrointestinal inflammation-cancer transformation; (B) precision prediction of therapeutic sensitivity and tumor immune microenvironment-based mechanistic exploration in gastrointestinal malignancies; (C) innovative biological, immune, and targeted therapies for digestive cancers. His work has impacted guideline updates by NCCN, ESMO, International Pancreatic Cancer Coalition (IPCC), and the Chinese Guidelines for Comprehensive Pancreatic Cancer Diagnosis and Treatment. Graduating with a Ph.D. (Summa Cum Laude) from Heidelberg Medical School, Heidelberg University, Germany, he has conducted research at the German Cancer Research Center (DKFZ), the US NIH/National Cancer Institute (NCI), and Shanghai Jiao Tong University School of Medicine. He has published over 100 SCI papers in high-impact journals including Gut (ESI Highly Cited), Nature Communications, Cancer Communications, Annals of Surgery (2 Editor’s Choice papers), Journal of Infection (ESI Highly Cited), BMC Medicine (2 Editor’s Choice papers), JAMA Surgery, and Clinical Cancer Research (Highlighted Article), comprising 31 Q1 papers (4 IF>20, 12 IF>10, total IF≈600), 3 ESI Highly Cited Papers, 1 cover article, with 4000 + citations (H-index=32). His research has been featured by Reuters Health, recommended by NEJM Journal Watch and F1000Prime, and incorporated into ESSO textbooks. He has secured over 6 million RMB in national/provincial grants, holds 17 patents/software copyrights, co-authored 2 textbooks/monographs, and serves as provincial grant reviewer, Youth Deputy Chair of municipal medical association, Associate/Academic Editor for iMeta, BMC Medicine, Cancer Medicine, BMJ Open, etc., and peer reviewer for The Lancet, BMJ, and Annals of Internal Medicine. Recognized as Shanghai Overseas Young Leadership Talent, Shanghai Pujiang Talent, and recipient of DKFZ Fellowship Award, NIH Visiting Fellow Award, ESMO Merit Award, and IGCC Young Investigator Award, he has delivered invited oral presentations at ASCO Annual Meeting and other major scientific conferences.