Diagnosis of Clostridioides difficile (CDI) is based on symptoms and guided by microbiological testing. Guidelines recommend multistep testing algorithms, which can generate indeterminate results [[1], [2], [3], [4]]. Due to the potential for this to indicate either colonization or low toxin producing infection, need for treatment here is an area of uncertainty [[1], [2], [3], [4]].

A concern with indeterminate tests is potential risk for overtreatment [5]. Studies have shown non-inferiority