Katz PO, Dunbar KB, Schnoll-Sussman FH et al (2022) ACG clinical guideline for the diagnosis and management of gastroesophageal reflux disease. Am J Gastroenterol 117(1):27–56

Article  PubMed  PubMed Central  Google Scholar 

Drug Profile “Aspirin.” https://pubchem.ncbi.nlm.nih.gov/compound/Aspirin (accessed in May 2025)

Angiolillo DJ, Capodanno D (2021) Aspirin for primary prevention of cardiovascular disease in the 21st century: a review of the evidence. Am J Cardiol 144(1):15–22. https://doi.org/10.1016/j.amjcard.2020.12.022

Article  CAS  Google Scholar 

Vane JR, Botting RM (2003) The mechanism of action of aspirin. Thromb Res 110(5):255–258. https://doi.org/10.1016/S0049-3848(03)00379-7

Article  CAS  PubMed  Google Scholar 

Tsujimoto H, Hirata Y, Ueda Y, Kinoshita N et al (2021) Effect of a proton-pump inhibitor on intestinal microbiota in patients taking low-dose aspirin. Eur J Clin Pharmacol 77(11):1639–1648. https://doi.org/10.1007/s00228-021-03167-0

Article  CAS  PubMed  Google Scholar 

Garnock-Jones KP (2015) Vonoprazan: first global approval. Drugs 75(4):439–443

Article  CAS  PubMed  Google Scholar 

Andersson K, Carlsson E (2005) Potassium-competitive acid blockade: a new therapeutic strategy in acid-related diseases. Pharmacol Ther 108(3):294–307

Article  CAS  PubMed  Google Scholar 

Niewęgłowski K, Wilczek N, Rycharski M, Niewęgłowska J (2022) Vonoprazan - A new drug for inhibiting gastric acid secretion. J Educ Health Sport 12(8):661–670. https://doi.org/10.12775/JEHS.2022.12.08.068

Article  Google Scholar 

Central Drugs Standard Control Organization (CDSCO) (2024) List of approved drugs from April 2024 to December 2024. Ministry of Health and Family Welfare, Government of India, New Delhi. https://cdsco.gov.in

Sugano K (2018) Vonoprazan fumarate, a novel potassiumcompetitive acid blocker, in the management of gastroesophageal reflux disease: safety and clinical evidence to date. Therap Adv Gastroenterol 11:1–14. https://doi.org/10.1177/1756283X17745776

Article  Google Scholar 

Kawai T, Oda K, Funao N, Nishimura A, Matsumoto Y, Mizokami Y et al (2018) Vonoprazan prevents low-dose aspirin-associated ulcer recurrence: randomised phase 3 study. Gut 67(6):1033–1041. https://doi.org/10.1136/gutjnl-2017-314852

Article  CAS  PubMed  Google Scholar 

Adis. Insight Drugs (2018) Aspirin/vonoprazan fumarate 100/10, Takeda https://adis.springer.com/drugs/800051463 (accessed on 15 May 2025)

Indian Pharmacopeia (2022) 9th Edn. Indian Pharmacopeia Commission, New Delhi, volume II, 1515 p.

British Pharmacopeia (2011) British Pharmacopeia Commission, London, volume I, 188 p.

British Pharmacopeia (2011) British Pharmacopeia Commission, London, volume III, 24 p.

United States Pharmacopeia (2017) National formulary, monograph of aspirin, Rockville, MD, pp 1–2.

Dacić M, Uzunovic A, Kunić A, et al. (2020) UV-VIS determination of acetylsalicylic acid in aspirin tablets using different solvents and conditions 73:563-567. https://doi.org/10.1007/978-3-030-17971-7_85

Sharma M, Pathak M, Roy B, Jain L et al (2015) Quantitative estimation of aspirin in various drugs: UV-Vis absorption spectroscopy and colorimetric studies. DU J Undergrad Res Innov 1:157–162

Google Scholar 

Reza H, Ahmed S (2013) The spectrophotometric multicomponent analysis of a ternary mixture of paracetamol aspirin and caffeine by the double divisor-ratio spectra derivative method. J Spectroscopy 2013:1–7. https://doi.org/10.1155/2013/405210

Article  CAS  Google Scholar 

Patel M, Patel H et al (2024) Quality by design approach driven development and validation of reverse phase-high-performance liquid chromatography methodology for dual quantification of aspirin and rivaroxaban. Sep Sci Plus 7(12):e202400169. https://doi.org/10.1002/sscp.202400169

Article  CAS  Google Scholar 

Sun DM, Zhang Y, Zhou Y, Feng XS, Zhang XY (2024) Progress of pretreatment and analytical methods of proton pump inhibitors: an update since 2010. Crit Rev Anal Chem 54(7):2325–2350

Article  CAS  PubMed  Google Scholar 

Patel VB, Patel AD, Shah DA (2018) Stability indicating liquid chromatographic method for simultaneous determination of aspirin and omeprazole. Curr Drug Discov Technol 15(4):351–360

Article  PubMed  Google Scholar 

Chandarana C, Kapupara P (2019) Quantitative simultaneous estimation of aspirin and omeprazole by RP-HPLC method implementing AQbD approach in pharmaceutical dosage form. Int J Pharm Sci Res 10(8):3777–3784. https://doi.org/10.13040/IJPSR.0975-8232.10(8).3777-84

Article  CAS  Google Scholar 

Bhusari VK, Dhaneshwar SR (2022) Method development and validation of simultaneous estimation of atenolol, amlodipine besylate and aspirin in bulk drug and formulation by HPTLC. Res J Pharm Technol 15(1):213–218. https://doi.org/10.52711/0974-360X.2022.0003

Article  Google Scholar 

Patel MM, Bansal K (2022) Development and application of HPTLC method fro estimation of rivaroxaban and aspirin in bulk drug and in house tablet form. J Chem Metrol 2:125–134

Article  Google Scholar 

Kashid A, Kolhe O (2019) Simultaneous densitometric determination of aspirin and omeprazole by high-performance thin-layer chromatography. J Planar Chromatogr Mod TLC 32(6):501–504. https://doi.org/10.1556/1006.2019.32.6.8

Article  CAS  Google Scholar 

Pyka-Pająk A, Dołowy M, Parys W et al (2018) A simple and cost-effective TLC-densitometric method for the quantitative determination of acetylsalicylic acid and ascorbic acid in combined effervescent tablets. Molecules 23(12):3115. https://doi.org/10.3390/molecules23123115

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wabaidur SM, Alothman ZA, Khan MR (2013) A rapid method for the simultaneous determination of l-ascorbic acid and acetylsalicylic acid in aspirin C effervescent tablet by ultra performance liquid chromatography–tandem mass spectrometry. Spectrochim Acta A Mol Biomol Spectrosc 108:20–25

Article  CAS  PubMed  Google Scholar 

Kanaga P (2024) Analytical method development and validation of RP-HPLC for the simultaneous estimation of vonoprazan and domperidone in pharmaceutical dosage form. Int J Pharm Sci 2(9):323–331. https://doi.org/10.5281/zenodo.13712320

Article  Google Scholar 

Pavani Y, Aravind S, Annam C, Rao MS (2024) Quantification and quality control of triple-drug combination employed for gastric ulcer using stability-indicating selective RP-HPLC technique. Int J Appl Pharm 16(3):140–148. https://doi.org/10.22159/ijap.2024v16i3.50320

Article  CAS  Google Scholar 

Sampath S, Elavarasan V (2024) RP-HPLC method development and validation for simultaneous estimation of amoxicillin, clarithromycin and vonoprazan in tablets. J Emerging Tech Innovative Res 11(4):500–508

Google Scholar 

Qiao Y, Huang J, Xu Y, Zhao J, Wang Q (2018) Determination of vonoprazan pyroglutamate and vonoprazan fumarate by HPLC. China Pharm 12(12):535–538

Google Scholar 

Abdelazim AH, Abdel-Fattah A, Osman AOE et al (2023) Spectrophotometric quantitative analysis of aspirin and vonoprazan fumarate in recently approved fixed-dose combination tablets using ratio spectra manipulating tools. J AOAC Int 106(2):490–495. https://doi.org/10.1093/jaoacint/qsac128

Article  PubMed  Google Scholar 

Kammoun AK, Hafez HM, Kamel EB, Fawzy MG (2024) A comparative analysis of univariate versus multivariate eco-friendly spectrophotometric manipulations for resolving severely overlapped spectra of vonoprazan and amoxicillin new combination. Anal Biochem 689:115501. https://doi.org/10.1016/j.ab.2024.115501

Article  CAS  PubMed  Google Scholar 

El-Maghrabey MH, El-Maraghy DA, El-Sadek M et al (2023) UV spectrophotometric method development and validation of vonoprazan fumarate in bulk and pharmaceutical dosage form; green profile evaluation via Eco-Scale and GAPI tools. Egypt J Chem 66(8):141–148. https://doi.org/10.21608/ejchem.2022.161704.6948

Article  Google Scholar 

El-Masry AA, Zeid AM (2024) Nano-scale analytical insights for determination of vonoprazan and aspirin in a recently approved combined preparation utilizing nucleophilic substitution reaction, along with evaluation approaches for both greenness and whiteness. Microchem J 197:109788. https://doi.org/10.1016/j.microc.2023.109788

Article  CAS  Google Scholar 

Bonam S, Siva Rao T, Rama Srinivas K, Suman P et al (2023) A novel RP-UPLC method development and validation for the simultaneous determination of vonoprazan and amoxicillin in fixed dosage combination. Eur Chem Bull S3:3571–3583

Google Scholar 

Salva C, Galla R (2014) The development and validation of a stability indicating RP-UPLC method for the simultaneous estimation of clarithromycin, amoxicillin, and vonoprazan in a physical mixture. J Appl Pharm Sci 14(5):193–202. https://doi.org/10.7324/JAPS.2024.165836

Article  Google Scholar 

Yoneyama T, Teshima K, Jinno F, Kondo T, Asahi S (2016) A validated simultaneous quantification method for vonoprazan (TAK-438F) and its 4 metabolites in human plasma by the liquid chromatography-tandem mass spectrometry. J Chromatogr B Anal Technol Biomed Life Sci 1015–1016:42–49

Article  Google Scholar 

Chen X, Chen T, Yunzhe H, Minhui W et al (2024) LC-MS/MS method for quick detection of vonoprazan fumarate in human plasma: development, validation and its application to a bioequivalence study. Biomed Chromatograph 38(6):e5860. https://doi.org/10.1002/bmc.5860

Article  CAS