Research trends and frontiers of the Apelin system in kidney diseases: a multi-database bibliometric analysis and cross-validation study

Levey AS, Eckardt K-U, Dorman NM et al (2020) Nomenclature for kidney function and disease: report of a Kidney Disease: Improving Global Outcomes (KDIGO) consensus conference. Kidney Int 97:1117–1129. https://doi.org/10.1016/j.kint.2020.02.010

Article  PubMed  Google Scholar 

Jager KJ, Kovesdy C, Langham R et al (2019) A single number for advocacy and communication—worldwide more than 850 million individuals have kidney diseases. Nephrol Dial Transplant 34:1803–1805. https://doi.org/10.1093/ndt/gfz174

Article  PubMed  Google Scholar 

Krisanapan P, Tangpanithandee S, Thongprayoon C et al (2023) Revolutionizing chronic kidney disease management with machine learning and artificial intelligence. J Clin Med 12:3018. https://doi.org/10.3390/jcm12083018

Article  PubMed  PubMed Central  Google Scholar 

Janssens P, Decuypere J-P, Bammens B et al (2022) The emerging role of the apelinergic system in kidney physiology and disease. Nephrol Dial Transplant 37:2314–2326. https://doi.org/10.1093/ndt/gfab070

Article  CAS  PubMed  Google Scholar 

Pan H, Li S, Ning Y, Hu Z (2025) Apelin-13 exerts protective effects against acute kidney injury by lysosomal function regulation. Ren Fail 47:2480243. https://doi.org/10.1080/0886022X.2025.2480243

Article  PubMed  PubMed Central  Google Scholar 

Fan C, Liu Y, Chang J et al (2025) Apelin alleviated endothelial‐to‐mesenchymal transition via increasing BKCa in diabetic nephropathy. FASEB J 39:e70747. https://doi.org/10.1096/fj.202500489R

Article  CAS  PubMed  Google Scholar 

Sainsily X, Coquerel D, Giguère H et al (2021) Elabela protects spontaneously hypertensive rats from hypertension and cardiorenal dysfunctions exacerbated by dietary high-salt intake. Front Pharmacol 12:709467. https://doi.org/10.3389/fphar.2021.709467

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu F, Wu M, Lu X et al (2022) Effect of Fc-Elabela-21 on renal ischemia/reperfusion injury in mice: mediation of anti-apoptotic effect via Akt phosphorylation. Peptides 147:170682. https://doi.org/10.1016/j.peptides.2021.170682

Article  CAS  PubMed  Google Scholar 

Chapman FA, Melville V, Godden E et al (2024) Cardiovascular and renal effects of apelin in chronic kidney disease: a randomised, double-blind, placebo-controlled, crossover study. Nat Commun 15:8387. https://doi.org/10.1038/s41467-024-52447-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Abudueryimu A, Shoukeer K, Ma H (2024) Analysis of the current status and hot topics in spinal schwannoma imaging research based on bibliometrics. Front Neurol 15:1408716. https://doi.org/10.3389/fneur.2024.1408716

Article  PubMed  PubMed Central  Google Scholar 

Chen H, Wang L, Wang W et al (2017) ELABELA and an ELABELA fragment protect against AKI. JASN 28:2694–2707. https://doi.org/10.1681/ASN.2016111210

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang W, Gan B, Wang T et al (2024) Extracellular vesicles in the treatment of oxidative stress injury: global research status and trends. Front Mol Biosci. https://doi.org/10.3389/fmolb.2023.1273113

Article  PubMed  PubMed Central  Google Scholar 

Dennis J, Witting P (2017) Protective role for antioxidants in acute kidney disease. Nutrients 9:718. https://doi.org/10.3390/nu9070718

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bircan B, Çakır M, Kırbağ S, Gül HF (2016) Effect of apelin hormone on renal ischemia/reperfusion induced oxidative damage in rats. Ren Fail 38:1122–1128. https://doi.org/10.1080/0886022X.2016.1184957

Article  CAS  PubMed  Google Scholar 

Liu Q, Duan S-B, Wang L et al (2023) Apelin-13 alleviates contrast-induced acute kidney injury by inhibiting endoplasmic reticulum stress. Ren Fail 45:2179852. https://doi.org/10.1080/0886022X.2023.2179852

Article  PubMed  PubMed Central  Google Scholar 

Zheng X, Chen D, Wu J et al (2025) Apelin-13 inhibits ischemia–reperfusion mediated podocyte apoptosis by reducing m- TOR phosphorylation to enhance autophagy. FASEB J 39:e70319. https://doi.org/10.1096/fj.202402850R

Article  CAS  PubMed  Google Scholar 

Xu F, Zhou H, Wu M et al (2020) Fc-elabela fusion protein attenuates lipopolysaccharide-induced kidney injury in mice. Biosci Rep 40:BSR20192397. https://doi.org/10.1042/BSR20192397

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xiong M, Chen H, Fan Y et al (2023) Tubular Elabela-APJ axis attenuates ischemia-reperfusion induced acute kidney injury and the following AKI-CKD transition by protecting renal microcirculation. Theranostics 13:3387–3401. https://doi.org/10.7150/thno.84308

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhong Y, Du X, Wang P et al (2024) Protective effect of Huashi Baidu formula against AKI and active ingredients that target SphK1 and PAI-1. Chin Med 19:152. https://doi.org/10.1186/s13020-024-01024-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mima A (2022) A narrative review of diabetic kidney disease: previous and current evidence-based therapeutic approaches. Adv Ther 39:3488–3500. https://doi.org/10.1007/s12325-022-02223-0

Article  PubMed  Google Scholar 

Mima A, Ohshiro Y, Kitada M et al (2011) Glomerular-specific protein kinase C-β-induced insulin receptor substrate-1 dysfunction and insulin resistance in rat models of diabetes and obesity. Kidney Int 79:883–896. https://doi.org/10.1038/ki.2010.526

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mima A, Yasuzawa T, King GL, Ueshima S (2018) Obesity-associated glomerular inflammation increases albuminuria without renal histological changes. FEBS Open Bio 8:664–670. https://doi.org/10.1002/2211-5463.12400

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mima A, Yasuzawa T (2022) Role of insulin signaling and its associated signaling in glomerulus for diabetic kidney disease. Histol Histopathol 38:487–492. https://doi.org/10.14670/HH-18-543

Article  PubMed  Google Scholar 

Mima A, Kitada M, Geraldes P et al (2012) Glomerular VEGF resistance induced by PKCδ/SHP‐1 activation and contribution to diabetic nephropathy. FASEB J 26:2963–2974. https://doi.org/10.1096/fj.11-202994

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mima A (2013) Inflammation and oxidative stress in diabetic nephropathy: new insights on its inhibition as new therapeutic targets. J Diabetes Res 2013:1–8. https://doi.org/10.1155/2013/248563

Article  Google Scholar 

Day RT, Cavaglieri RC, Feliers D (2013) Apelin retards the progression of diabetic nephropathy. Am J Physiol Renal Physiol 304:F788–F800. https://doi.org/10.1152/ajprenal.00306.2012

Article  CAS  PubMed  Google Scholar 

Chen H, Li J, Jiao L et al (2014) Apelin inhibits the development of diabetic nephropathy by regulating histone acetylation in Akita mouse. J Physiol 592:505–521. https://doi.org/10.1113/jphysiol.2013.266411

Article  CAS  PubMed  Google Scholar 

Yin J, Wang Y, Chang J et al (2018) Apelin inhibited epithelial−mesenchymal transition of podocytes in diabetic mice through downregulating immunoproteasome subunits β5i. Cell Death Dis 9:1031. https://doi.org/10.1038/s41419-018-1098-4

Article 

Comments (0)

No login
gif