At the 34th meeting of the American Association of Clinical Endocrinology, held on May 15 to 17 2025 in Orlando, Florida, the presentation “Thyroid Year-in-Review”, by Dr Malini Gupta, summarized 14 carefully selected peer-reviewed articles published between May 2024 and March 2025 relevant for the practicing endocrinologist. These articles were chosen for addressing unanswered questions or highlighting new directions that shape the field of thyroidology, acknowledging that many other outstanding studies have also advanced the discipline. Although the Thyroid Year-in-Review was presented by a single thyroid expert who selected the most impactful papers of the year, this summary was further reviewed by a group of endocrinologists from both academic and private practice settings, to provide complementary clinical perspectives with their insights highlighting the importance of the papers and how the key findings and interpretations apply to everyday endocrine practice. The publications of interest cover topics including thyroid nodules and cancer, autoimmune thyroid dysfunction, thyroid disease in pregnancy, the interplay between sleep and thyroid function, aging and thyroid physiology, and the rapidly expanding role of artificial intelligence (AI) in thyroidology and are summarized in the Table and Figure.1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12