Neuronal expressions of Taxi and Adar are crucial in maintaining the lifespan of

Biteau B., Karpac J., Hwangbo D. and Jasper H. 2011 Regulation of Drosophila lifespan by JNK signaling. Exp. Gerontol. 46, 349–354.

Article  PubMed  CAS  Google Scholar 

Broughton S. J., Piper M. D., Ikeya T., Bass T. M., Jacobson J., Driege Y. et al. 2005 Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands. Proc. Natl. Acad. Sci. USA 102, 3105–3110.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Broughton S. J., Slack C., Alic N., Metaxakis A., Bass T. M., Driege Y. et al. 2010 DILP-producing median neurosecretory cells in the Drosophila brain mediate the response of lifespan to nutrition. Aging Cell 9, 336–346.

Article  PubMed  CAS  Google Scholar 

Burnett C., Valentini S., Cabreiro F., Goss M., Somogyvári M., Piper M. D. et al. 2011 Absence of effects of Sir2 over-expression on lifespan in C. elegans and Drosophila. Nature 477, 482–485.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Castillo-Armengol J., Fajas L. and Lopez-Mejia I. C. 2019 Inter-organ communication: a gatekeeper for metabolic health. EMBO Rep. 20, e47903.

Article  PubMed  PubMed Central  Google Scholar 

Cui X. B., Fei J., Chen S., Edwards G. L. and Chen S. Y. 2021 ADAR1 deficiency protects against high-fat diet-induced obesity and insulin resistance in mice. Am. J. Physiol. Endocrinol. Metab. 320, E131–E138.

Article  PubMed  CAS  Google Scholar 

de Mendoza A., Jones J. and Friedrich M. 2016 Methuselah/Methuselah-like G protein-coupled receptors constitute an ancient metazoan gene family. Sci. Rep. 6, 21801.

Article  PubMed  PubMed Central  Google Scholar 

Demontis F. and Perrimon N. 2010 FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging. Cell 143, 813–825.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Deng P., Khan A., Jacobson D., Sambrani N., McGurk L., Li X. et al. 2020 Adar RNA editing-dependent and -independent effects are required for brain and innate immune functions in Drosophila. Nat. Commun. 11, 1580.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Duan Y., Dou S., Luo S., Zhang H. and Lu J. 2017 Adaptation of A-to-I RNA editing in Drosophila. PLoS Genet. 13, e1006648.

Article  PubMed  PubMed Central  Google Scholar 

Egoz-Matia N., Nachman A., Halachmi N., Toder M., Klein Y. and Salzberg A. 2011 Spatial regulation of cell adhesion in the Drosophila wing is mediated by Delilah, a potent activator of βPS integrin expression. Dev. Biol. 351, 99–109.

Article  PubMed  CAS  Google Scholar 

Fernando M. D., Kounatidis I. and Ligoxygakis P. 2014 Loss of Trabid, a new negative regulator of the Drosophila immune-deficiency pathway at the level of TAK1, reduces life span. PLoS Genet. 10, e1004117.

Article  PubMed  PubMed Central  Google Scholar 

Galeano F., Tomaselli S., Locatelli F. and Gallo A. 2012 A-to-I RNA editing: the “ADAR” side of human cancer. Semin. Cell Dev. Biol. 23, 244–250.

Article  PubMed  CAS  Google Scholar 

Garschall K. and Flatt T. 2018 The interplay between immunity and aging in Drosophila. F1000Res. 7, 160.

Giannakou M. E. and Partridge L. 2007 Role of insulin-like signalling in Drosophila lifespan. Trends Biochem. Sci. 32, 180–188.

Article  PubMed  CAS  Google Scholar 

Giannakou M. E., Goss M., Jünger M. A., Hafen E., Leevers S. J. and Partridge L. 2004 Long-lived Drosophila with over-expressed dFOXO in adult fat body. Science 305, 361.

Article  PubMed  CAS  Google Scholar 

Gilbert S. F. 2000 Aging: The biology of senescence. In Developmental biology, 6th edition, Sinauer Associates, Sunderland, Massachusetts.

Goddard T. D., Huang C. C., Meng E. C., Pettersen E. F., Couch G. S., Morris J. H. et al. 2018 UCSF ChimeraX: Meeting modern challenges in visualization and analysis. Protein Sci. 27, 14–25.

Article  PubMed  CAS  Google Scholar 

Gramates L. S., Agapite J., Attrill H., Calvi B. R., Crosby M. A., Dos Santos G. et al. 2022 FlyBase: a guided tour of highlighted features. Genetics 220, iyac035.

Grant C. E., Bailey T. L. and Noble W. S. 2011 FIMO: scanning for occurrences of a given motif. Bioinformatics 27, 1017–1018.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hall B. S., Barnett Y. A., Crofts J. J. and Chuzhanova N. 2019 Identification of novel genes associated with longevity in Drosophila melanogaster – a computational approach. Aging 11, 11244–11267.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hassan A., Timerman Y., Hamdan R., Sela N., Avetisyan A., Halachmi N. et al. 2018 An RNAi screen identifies new genes required for normal morphogenesis of larval chordotonal organs. G3 (Bethesda) 8, 1871–1884.

Hur J. H., Bahadorani S., Graniel J., Koehler C. L., Ulgherait M., Rera M. et al. 2013 Increased longevity mediated by yeast NDI1 expression in Drosophila intestinal stem and progenitor cells. Aging 5, 662–681.

Article  PubMed  PubMed Central  Google Scholar 

Hwangbo D. S., Gershman B., Tu M. P., Palmer M. and Tatar M. 2004 Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature 429, 562–566.

Article  PubMed  CAS  Google Scholar 

Iwamoto K. and Kato T. 2003 RNA editing of serotonin 2C receptor in human postmortem brains of major mental disorders. Neurosci. Lett. 346, 169–172.

Article  PubMed  CAS  Google Scholar 

Jumper J., Evans R., Pritzel A., Green T., Figurnov M., Ronneberger O. et al. 2021 Highly accurate protein structure prediction with AlphaFold. Nature 596, 583–589.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kapahi P., Zid B. M., Harper T., Koslover D., Sapin V. and Benzer S. 2004 Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr. Biol. 14, 885–890.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kapan N., Lushchak O. V., Luo J. and Nässel D. R. 2012 Identified peptidergic neurons in the Drosophila brain regulate insulin-producing cells, stress responses and metabolism by coexpressed short neuropeptide F and corazonin. Cell. Mol. Life Sci. 69, 4051–4066.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Karpac J., Hull-Thompson J., Falleur M. and Jasper H. 2009 JNK signaling in insulin-producing cells is required for adaptive responses to stress in Drosophila. Aging Cell 8, 288–295.

Article  PubMed  CAS  Google Scholar 

Katewa S. D. and Kapahi P. 2011 Role of TOR signaling in aging and related biological processes in Drosophila melanogaster. Exp. Gerontol. 46, 382–390.

Article  PubMed  CAS  Google Scholar 

Keegan L. P., Brindle J., Gallo A., Leroy A., Reenan R. A. and O’Connell M. A. 2005 Tuning of RNA editing by ADAR is required in Drosophila. EMBO J. 24, 2183–2193.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kent W. J., Sugnet C. W., Furey T. S., Roskin K. M., Pringle T. H., Zahler A. M. et al. 2002 The human genome browser at UCSC. Genome Res. 12, 996–1006.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lagarrigue S., Hormozdiari F., Martin L. J., Lecerf F., Hasin Y., Rau C. et al. 2013 Limited RNA editing in exons of mouse liver and adipose. Genetics 193, 1107–1115.

Article 

Comments (0)

No login
gif