Lim C, Compagnon P, Sebagh M, Salloum C, Calderaro J, Luciani A, et al. Hepatectomy for hepatocellular carcinoma larger than 10 cm: preoperative risk stratification to prevent futile surgery. HPB. 2015;17(7):611–23.

Article  PubMed  PubMed Central  Google Scholar 

Mok KT, Wang BW, Lo GH, Liang HL, Liu SI, Chou NH, et al. Multimodality management of hepatocellular carcinoma larger than 10 cm. J Am Coll Surg. 2003;197(5):730–8.

Article  PubMed  Google Scholar 

Huang YH, Wu JC, Chen SC, Chen CH, Chiang JH, Huo TI, et al. Survival benefit of transcatheter arterial chemoembolization in patients with hepatocellular carcinoma larger than 10 cm in diameter. Aliment Pharmacol Ther. 2006;23(1):129–35.

Article  PubMed  Google Scholar 

Kim KH, Kim MS, Chang JS, Han KH, Kim DY, Seong J. Therapeutic benefit of radiotherapy in huge (>/=10 cm) unresectable hepatocellular carcinoma. Liver Int. 2014;34(5):784–94.

Article  CAS  PubMed  Google Scholar 

Que JY, Lin LC, Lin KL, Lin CH, Lin YW, Yang CC. The efficacy of stereotactic body radiation therapy on huge hepatocellular carcinoma unsuitable for other local modalities. Radiat Oncol. 2014;9:120.

Article  PubMed  PubMed Central  Google Scholar 

Zhong NB, Lv GM, Chen ZH. Stereotactic body radiotherapy combined with transarterial chemoembolization for huge (>/=10 cm) hepatocellular carcinomas: a clinical study. Mol Clin Oncol. 2014;2(5):839–44.

Article  PubMed  PubMed Central  Google Scholar 

Xue T, Le F, Chen R, Xie X, Zhang L, Ge N, et al. Transarterial chemoembolization for huge hepatocellular carcinoma with diameter over ten centimeters: a large cohort study. Med Oncol. 2015;32(3):64.

Article  PubMed  Google Scholar 

Li JH, Xie XY, Zhang L, Le F, Ge NL, Li LX, et al. Oxaliplatin and 5-fluorouracil hepatic infusion with lipiodolized chemoembolization in large hepatocellular carcinoma. World J Gastroenterol. 2015;21(13):3970–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dong J, Zhai X, Chen Z, Liu Q, Ye H, Chen W, et al. Treatment of huge hepatocellular carcinoma using cinobufacini injection in transarterial chemoembolization: a retrospective study. Evid Based Complement Alternat Med. 2016;2016:2754542.

Article  PubMed  PubMed Central  Google Scholar 

Wei Y, Dai F, Zhao T, Tao C, Wang L, Ye W, et al. Transcatheter arterial chemoembolization monotherapy vs combined transcatheter arterial chemoembolization-percutaneous microwave coagulation therapy for massive hepatocellular carcinoma (>/=10 cm). Cancer Manag Res. 2018;10:5273–82.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Miyayama S, Kikuchi Y, Yoshida M, Yamashiro M, Sugimori N, Ikeda R, et al. Outcomes of conventional transarterial chemoembolization for hepatocellular carcinoma >/=10 cm. Hepatol Res. 2019;49(7):787–98.

Article  CAS  PubMed  Google Scholar 

Kim GH, Kim JH, Shim JH, Ko HK, Chu HH, Shin JH, et al. Chemoembolization for single large hepatocellular carcinoma with preserved liver function: analysis of factors predicting clinical outcomes in a 302 patient cohort. Life. 2021;11(8):840.

Article  PubMed  PubMed Central  Google Scholar 

Hidaka T, Anai H, Sakaguchi H, Sueyoshi S, Tanaka T, Yamamoto K, et al. Efficacy of combined bland embolization and chemoembolization for huge (>/=10 cm) hepatocellular carcinoma. Minim Invasive Ther Allied Technol. 2021;30(4):221–8.

Article  PubMed  Google Scholar 

Yu SCH, Hui JW, Li L, Cho CC, Hui EP, Chan SL, et al. Comparison of Chemoembolization, Radioembolization, and Transarterial Ethanol Ablation for Huge Hepatocellular Carcinoma (>/= 10 cm) in Tumour Response and Long-Term Survival Outcome. Cardiovasc Intervent Radiol. 2022;45(2):172–81.

Article  PubMed  Google Scholar 

Liu F, Brown DR, Munley MT. Optimal hypofractionated radiation therapy schemes for early-stage hepatocellular carcinoma. Radiother Oncol. 2024;194:110223.

Article  CAS  PubMed  Google Scholar 

Wei L, Simeth J, Aryal MP, Matuszak M, Haken RKT, Cuneo K, et al. The effect of stereotactic body radiation therapy for hepatocellular cancer on regional hepatic liver function. Int J Radiat Oncol Biol Phys. 2023;115(3):794–802.

Article  PubMed  Google Scholar 

Cheng JY, Liu CM, Wang YM, Hsu HC, Huang EY, Huang TT, et al. Proton versus photon radiotherapy for primary hepatocellular carcinoma: a propensity-matched analysis. Radiat Oncol. 2020;15(1):159.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sanford NN, Pursley J, Noe B, Yeap BY, Goyal L, Clark JW, et al. Protons versus photons for unresectable hepatocellular carcinoma: liver decompensation and overall survival. Int J Radiat Oncol Biol Phys. 2019;105(1):64–72.

Article  CAS  PubMed  Google Scholar 

Sugahara S, Oshiro Y, Nakayama H, Fukuda K, Mizumoto M, Abei M, et al. Proton beam therapy for large hepatocellular carcinoma. Int J Radiat Oncol Biol Phys. 2010;76(2):460–6.

Article  PubMed  Google Scholar 

Bhangoo RS, Mullikin TC, Ashman JB, Cheng TW, Golafshar MA, DeWees TA, et al. Intensity Modulated Proton Therapy for Hepatocellular Carcinoma: Initial Clinical Experience. Adv Radiat Oncol. 2021;6(4):100675.

Article  PubMed  PubMed Central  Google Scholar 

Yoo GS, Yu JI, Cho S, Jung SH, Han Y, Park S, et al. Comparison of clinical outcomes between passive scattering versus pencil-beam scanning proton beam therapy for hepatocellular carcinoma. Radiother Oncol. 2020;146:187–93.

Article  CAS  PubMed  Google Scholar 

Fukumitsu N, Sugahara S, Nakayama H, Fukuda K, Mizumoto M, Abei M, et al. A prospective study of hypofractionated proton beam therapy for patients with hepatocellular carcinoma. Int J Radiat Oncol Biol Phys. 2009;74(3):831–6.

Article  PubMed  Google Scholar 

Mizumoto M, Okumura T, Hashimoto T, Fukuda K, Oshiro Y, Fukumitsu N, et al. Proton beam therapy for hepatocellular carcinoma: a comparison of three treatment protocols. Int J Radiat Oncol Biol Phys. 2011;81(4):1039–45.

Article  PubMed  Google Scholar 

Wang G, Zhu S, Li X. Comparison of values of CT and MRI imaging in the diagnosis of hepatocellular carcinoma and analysis of prognostic factors. Oncol Lett. 2019;17(1):1184–8.

PubMed  Google Scholar 

Yu JI, Park HC, Lim DH, Choi Y, Jung SH, Paik SW, et al. The role of diffusion-weighted magnetic resonance imaging in the treatment response evaluation of hepatocellular carcinoma patients treated with radiation therapy. Int J Radiat Oncol Biol Phys. 2014;89(4):814–21.

Article  PubMed  Google Scholar 

Lencioni R, Llovet JM. Modified RECIST (mRECIST) assessment for hepatocellular carcinoma. Semin Liver Dis. 2010;30(1):52–60.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hung YW, Lee IC, Chi CT, Lee RC, Liu CA, Chiu NC, et al. Redefining tumor burden in patients with intermediate-stage hepatocellular carcinoma: the seven-eleven criteria. Liver Cancer. 2021;10(6):629–40.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schmidt CM, Turrini O, Parikh P, House MG, Zyromski NJ, Nakeeb A, et al. Effect of hospital volume, surgeon experience, and surgeon volume on patient outcomes after pancreaticoduodenectomy: a single-institution experience. Arch Surg. 2010;145(7):634–40.

Article  PubMed  Google Scholar 

Naghavi AO, Echevarria MI, Strom TJ, Abuodeh YA, Venkat PS, Ahmed KA, et al. Patient choice for high-volume center radiation impacts head and neck cancer outcome. Cancer Med. 2018;7(10):4964–79.

Article  PubMed  PubMed Central  Google Scholar 

Lin SM, Ku HY, Chang TC, Liu TW, Chang CS, Hong JH. Outcomes for cervical cancer patients treated with radiation in high-volume and low-volume hospitals. Int J Radiat Oncol Biol Phys. 2018;102(1):184–93.

Article  PubMed  Google Scholar 

Niitsu H, Mizumoto M, Li Y, Nakamura M, Ishida T, Iizumi T, et al. Tumor response on diagnostic imaging after proton beam therapy for hepatocellular carcinoma. Cancers. 2024;16(2):357.

Article  PubMed  PubMed Central