Oxysterol Induced Fluid-Fluid Phase Separation in Saturated Phosphatidylcholine Membranes: Influence of Lipid Chain Length

Angelova MI, Dimitrov DS (1986) Liposome electroformation Fraday Discuss Chem Soc 81:303–311

Article  CAS  Google Scholar 

Attwood SJ, Choi Y, Leonenko Z (2013) Preparation of dopc and dppc supported planar lipid bilayers for atomic force microscopy and atomic force spectroscopy. Int J Mol Sci 14(2):3514–3539. https://doi.org/10.3390/ijms14023514

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bagatolli L, Sunil Kumar PB (2009) Phase behavior of multicomponent membranes: experimental and computational techniques. Soft Matter 5:3234–3248. https://doi.org/10.1039/B901866B

Article  CAS  Google Scholar 

Dufourc EJ, Parish EJ, Chitrakorn S, Smith ICP (1984) Structural and dynamical details of cholesterol-lipid interaction as revealed by deuterium nmr. Biochemistry 23(25):6062–6071. https://doi.org/10.1021/bi00320a025

Article  CAS  Google Scholar 

Gale S, Westover E, Dudley N, Krishnan K, Merlin S, Scherrer D, Han X, Zhai X, Brockman H, Brown R, Covey D, Schaffer J, Schlesinger PH, Ory DS (2009) Side chain oxygenated cholesterol regulates cellular cholesterol homeostasis through direct sterol-membrane interactions. J Biol Chem 284:1755–1764

Article  CAS  PubMed  PubMed Central  Google Scholar 

Goldstein RE, Walker JS (1983) Theory of multiple phase separations in binary mixtures: phase diagrams, thermodynamic properties, and comparisons with experiments. J Chem Phys 78:1492–1512

Article  CAS  Google Scholar 

Hung W-C, Lee M-T, Chen F-Y, Huang HW (2007) The condensing effect of cholesterol in lipid bilayers. Biophys J 92:3960–3967

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ipsen JH, Karlström G, Mouritsen OG, Wennerström H, Zuckermann MJ (1987) Phase equilibria in the phosphotidylcholine-cholesterol system. Biochim Biophys Acta 905:162–172

Article  CAS  PubMed  Google Scholar 

Kamal MA, Polley A, Shabeeb PK, Raghunathan VA (2023) Closed-loop fluid-fluid immiscibility in binary lipid-sterol membranes. Proc Natl Acad Sci 120(25):2216002120. https://doi.org/10.1073/pnas.2216002120 (https://www.pnas.org/doi/pdf/10.1073/pnas.2216002120)

Article  CAS  Google Scholar 

Karmakar S, Raghunathan VA (2003) Cholesterol-induced modulated phase in phospholipid membranes. Phys Rev Lett 91:098102

Article  PubMed  Google Scholar 

Karmakar S, Raghunathan VA (2005) Structure of phospholipid-cholesterol membranes: an x-ray diffraction study. Phys Rev E 71:061924

Article  Google Scholar 

Kučerka N, Liu Y, Chu N, Petrache HI, Tristram-Nagle S, Nagle JF (2005) Structure of fully hydrated fluid phase dmpc and dlpc lipid bilayers using x-ray scattering from oriented multilamellar arrays and from unilamellar vesicles. Biophys J 88:2626–2637

Article  PubMed  PubMed Central  Google Scholar 

Lingwood D, Simons K (2010) Lipid rafts as membrane-organizing principle. Science 327:46

Article  CAS  PubMed  Google Scholar 

Marquardt D, Heberle FA, Greathouse DV, Koeppe RE, Standaert RF, Van Oosten BJ, Harroun TA, Kinnun JJ, Williams JA, Wassall SR, Katsaras J (2016) Lipid bilayer thickness determines cholesterol’s location in model membranes. Soft Matter 12:9417–9428. https://doi.org/10.1039/C6SM01777K

Article  CAS  PubMed  Google Scholar 

Nagle JF, Tristram-Nagle S (2000) Structure of lipid bilayers. Biochim Biophys Acta 1469:159–195

Article  CAS  PubMed  PubMed Central  Google Scholar 

Narayanan T, Kumar A (1994) Reentrant phase transitions in multicomponent liquid mixtures. Phys Rep 249:135–218

Article  CAS  Google Scholar 

Olsen BN, Schlesinger PH, Ory DS, Baker NA (2012) Side-chain oxysterols: from cells to membranes to molecules. Biochim Biophys Acta 1818:330–336

Article  CAS  PubMed  Google Scholar 

Parisio G, Sperotto MM, Ferrarini A (2012) Flip-flop of steroids in phospholipid bilayer: effect of chemical structure on transbilayer diffusion. J Am Chem Soc 134:12198–12208

Article  CAS  PubMed  Google Scholar 

Sankaram MB, Thompson TE (1991) Cholesterol-induced fluid-phase immiscibility in membranes. Proc Natl Acad Sci U S A 88:8686–8690

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sezgin E, Levental I, Mayor S, Eggeling C (2017) The mystery of membrane organization: composition, regulation and physiological relevance of lipid rafts. Nat Rev Mol Cell Biol 18:361–374

Article  CAS  PubMed  PubMed Central  Google Scholar 

Simons K, Ikonnen E (1997) Functional rafts in cell membranes. Nature 389:569

Article  Google Scholar 

Veatch SL, Soubias O, Keller SL, Gawrisch K (2007) Critical fluctuations in domain-forming lipid mixtures. Proc Natl Acad Sci U S A 104:17650

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vist MR, Davis JH (1990) Phase equilibria of cholesterol/dipalmitoylphosphatidylcholine mixtures: deuterium nuclear magnetic resonance and differential scanning calorimetry. Biochemistry 29:451

Article  CAS  PubMed  Google Scholar 

Wack DC, Webb WW (1989) Synchrotron x-ray study of the modulated lamellar phase \(_ }\) in the lecithin-water system. Phys Rev A 40:2712–2730. https://doi.org/10.1103/PhysRevA.40.2712

Article  CAS  Google Scholar 

Zu S, Deng Y-Q, Zhou C, Li J, Li L, Chen Q, Li X-F, Zhao H, Gold S, He J, Li X, Zhang C, Yang H, Cheng G, Qin C-F (2020) 25-hydroxycholesterol is a potent sars-cov-2 inhibitor. Cell Res 30:1043–1045

Article  CAS  PubMed  Google Scholar 

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