Chan J, Yoshida A, Emile J, et al. (2024) ALK-positive histiocytosis. In: WHO classification of tumours editorial board. haematolymphoid tumours [Internet]. Lyon (France): International Agency for Research on Cancer (WHO classification of tumours series, 5th ed.; vol. 11). Available from: https://tumourclassification.iarc.who.int/chapters/63
Chan JK, Lamant L, Algar E, Delsol G, Tsang WY, Lee KC, Tiedemann K, Chow CW (2008) ALK+ histiocytosis: a novel type of systemic histiocytic proliferative disorder of early infancy. Blood 112(7):2965–2968. https://doi.org/10.1182/blood-2008-03-147017
Article CAS PubMed Google Scholar
Kemps PG, Picarsic J, Durham BH, Hélias-Rodzewicz Z, Hiemcke-Jiwa L, van den Bos C, van de Wetering MD, van Noesel CJM, van Laar JAM, Verdijk RM, Flucke UE, Hogendoorn PCW, Woei-A-Jin FJSH, Sciot R, Beilken A, Feuerhake F, Ebinger M, Möhle R, Fend F, Bornemann A, Wiegering V, Ernestus K, Méry T, Gryniewicz-Kwiatkowska O, Dembowska-Baginska B, Evseev DA, Potapenko V, Baykov VV, Gaspari S, Rossi S, Gessi M, Tamburrini G, Héritier S, Donadieu J, Bonneau-Lagacherie J, Lamaison C, Farnault L, Fraitag S, Jullié ML, Haroche J, Collin M, Allotey J, Madni M, Turner K, Picton S, Barbaro PM, Poulin A, Tam IS, El Demellawy D, Empringham B, Whitlock JA, Raghunathan A, Swanson AA, Suchi M, Brandt JM, Yaseen NR, Weinstein JL, Eldem I, Sisk BA, Sridhar V, Atkinson M, Massoth LR, Hornick JL, Alexandrescu S, Yeo KK, Petrova-Drus K, Peeke SZ, Muñoz-Arcos LS, Leino DG, Grier DD, Lorsbach R, Roy S, Kumar AR, Garg S, Tiwari N, Schafernak KT, Henry MM, van Halteren AGS, Abla O, Diamond EL, Emile JF (2022) ALK-positive histiocytosis: a new clinicopathologic spectrum highlighting neurologic involvement and responses to ALK inhibition. Blood. 139(2):256–280. https://doi.org/10.1182/blood.2021013338. Erratum in: Blood. 2023. 141(22):2785–2786. 10.1182/blood.2022017205
Jaber OI, Jarrah DA, Hiasat M, Hussaini MA (2021) ALK-positive histiocytosis: a case report and literature review. Turk Patoloji Derg 37(2):172–177. https://doi.org/10.5146/tjpath.2020.01507
Article PubMed PubMed Central Google Scholar
Tian Y, Li J, Liu B, Xie H, Zheng M, Yao W (2021) ALK-positive histiocytosis with disseminated disease responded to alectinib: a case report. Ann Palliat Med 10(9):10095–10101. https://doi.org/10.21037/apm-21-2117
Wei Y, Zhang R, Lin D, Chen X, Li L, Huang H (2024) Case report: systemic presentation of ALK-positive Histiocytosis. Front Oncol 19(14):1366766. https://doi.org/10.3389/fonc.2024.1366766
Lee JY, Lee KR, Na S, Na HY, Lee S, Kim SA, Lee JO, Bang SM, Kim JH, Paik JH (2025) ALK-positive adult histiocytosis with a TFG-ALKfusion gene. Oncologist 30(9):oyaf221. https://doi.org/10.1093/oncolo/oyaf221
Article CAS PubMed PubMed Central Google Scholar
Chang KTE, Tay AZE, Kuick CH, Chen H, Algar E, Taubenheim N, Campbell J, Mechinaud F, Campbell M, Super L, Chantranuwat C, Yuen ST, Chan JKC, Chow CW (2019) ALK-positive histiocytosis: an expanded clinicopathologic spectrum and frequent presence of KIF5B-ALK fusion. Mod Pathol 32(5):598–608. https://doi.org/10.1038/s41379-018-0168-6
Zhao D, Sun J, Cao X (2024) ALK-positive histiocytosis with central nervous system involvement successfully treated with alectinib: a rare case report. Neurol Sci 45(12):5963–5966. https://doi.org/10.1007/s10072-024-07723-1
Qiu L, Weitzman SP, Nastoupil LJ, Williams MD, Medeiros LJ, Vega F (2021) Disseminated ALK-positive histiocytosis with KIF5B-ALK fusion in an adult. Leuk Lymphoma 62(5):1234–1238. https://doi.org/10.1080/10428194.2020.1861273
Article CAS PubMed Google Scholar
Xu J, Huang X, Wen Y, Pan Z, Lian H, Zhao M, Li M, Duan Z, Zhang Y, Zhang G, Qi X, Tang J, Xu Z, Gao Z, Fu L, Ma L (2023) Systemic juvenile xanthogranuloma has a higher frequency of ALK translocations than BRAFV600E mutations. J Am Acad Dermatol 88(3):656–659. https://doi.org/10.1016/j.jaad.2020.08.053
Zhou Y, Hurtado-Castillo M, Pandey O (2023) Case report: ALK-positive histiocytosis presented as bilateral synchronous breast masses with long-term remission on crizotinib. Front Med (Lausanne) 29(10):1288849. https://doi.org/10.3389/fmed.2023.1288849
Tu Y, Lu Y (2024) Anaplastic lymphoma kinase-positive histiocytosis with multisystem involvement: a case report. Pediatr Dermatol 41(3):551–553. https://doi.org/10.1111/pde.15546
Wolter NE, Ngan B, Whitlock JA, Dickson BC, Propst EJ (2019) Atypical juvenile histiocytosis with novel KIF5B-ALK gene fusion mimicking subglottic hemangioma. Int J Pediatr Otorhinolaryngol 126:109585. https://doi.org/10.1016/j.ijporl.2019.07.010
Zhang L, Fink D, Pan Z (2025) A rare case of laryngeal ALK-positive histiocytosis with PRKAR1A::ALK fusion. Ear Nose Throat J 20:1455613251342897. https://doi.org/10.1177/01455613251342897
Phillips GS, Knapp M, Olsen KC, Martin W, Hayes-Lattin B, Chung J (2025) Multisystem ALK-Positive Histiocytosis With DCTN1::ALK fusion in an adult, responsive to alectinib: case report and literature review. J Cutan Pathol 52(1):63–71. https://doi.org/10.1111/cup.14732
Aoki Y, Maeda M, Kishi S, Kogue R, Tanaka F, Umino M, Takeoka M, Hanaki R, Hirayama J, Yuasa H, Imai H, Hirayama M, Sakuma H (2022) Central nervous system involvement of systemic ALK-positive histiocytosis with KIF5B-ALK fusion. Radiol Case Rep 17(10):3867–3870. https://doi.org/10.1016/j.radcr.2022.07.072
Article PubMed PubMed Central Google Scholar
Alizadeh M, Ravindran A, Chkheidze R, Goyal G, Hosseini M, Shobeiri P, Shafieioun A, Khalafi M, Shahidi R, Sotoudeh H, Singhal A (2023) ALK-positive histiocytosis involving the cavernous sinus: A deceptive radiologic mimic of meningioma. Radiol Case Rep 18(6):2259–2263. https://doi.org/10.1016/j.radcr.2023.03.034
Article PubMed PubMed Central Google Scholar
Wang S, Huang H-Y, Medeiros LJ, Chang K-C (2023) ALK-positive histiocytosis of external auditory canal in a 3-year-old boy. Am J Hematol. https://doi.org/10.1002/ajh.27143
Breimer GE, Rozeman EA, Braunius WW, Daenen LGM, Kester LA, Leguit RJ, Mahieu R, Solleveld-Westerink N, Straatman L, Schutgens F (2025) ALK-positive histiocytosis and a clonally related chronic myelomonocytic leukemia. Haematologica. https://doi.org/10.3324/haematol.2025.288275
Article PubMed PubMed Central Google Scholar
Feng X, Tao J, He N, Wang J, He L, Zhang N (2024) ALK-positive histiocytosis in 12 Asian children. Hum Pathol 152:105637. https://doi.org/10.1016/j.humpath.2024.105637
Article CAS PubMed Google Scholar
Kashima J, Yoshida M, Jimbo K, Izutsu K, Ushiku T, Yonemori K, Yoshida A (2021) ALK-positive Histiocytosis of the Breast: A Clinicopathologic Study Highlighting Spindle Cell Histology. Am J Surg Pathol 45(3):347–355. https://doi.org/10.1097/PAS.0000000000001567
Osako T, Kurisaki-Arakawa A, Dobashi A, Togashi Y, Baba S, Shiozawa S, Ishigame H, Ishige H, Ohno S, Ishikawa Y, Takeuchi K (2022) Distinct clinicopathologic features and possible pathogenesis of localized ALK-positive histiocytosis of the breast. Am J Surg Pathol 46(3):344–352. https://doi.org/10.1097/PAS.0000000000001794
Coffin CM, Watterson J, Priest JR, Dehner LP (1995) Extrapulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor): a clinicopathologic and immunohistochemical study of 84 cases. Am J Surg Pathol 19(8):859–872. https://doi.org/10.1097/00000478-199508000-00001
Article CAS PubMed Google Scholar
Baranov E, Hornick JL (2020) Soft tissue special issue: fibroblastic and myofibroblastic neoplasms of the Head and Neck. Head Neck Pathol 14(1):43–58. https://doi.org/10.1007/s12105-019-01104-3
Article PubMed PubMed Central Google Scholar
Gleason BC, Hornick JL (2008) Inflammatory myofibroblastic tumours: where are we now? J Clin Pathol 61(4):428–437. https://doi.org/10.1136/jcp.2007.049387
Article CAS PubMed Google Scholar
Agaimy A, Stoehr R, Fisher C, Chrisinger JSA, Demicco EG, Tögel L, Michal M, Michal M (2024) ALK -rearranged mesenchymal neoplasms with prominent foamy/pseudolipogenic cell morphology: expanding the phenotypic spectrum of ALK fusion neoplasms and report of novel fusion partners. Am J Surg Pathol 48(11):1455–1463. https://doi.org/10.1097/PAS.0000000000002283
Dermawan JK, DiNapoli SE, Mullaney KA, Sukhadia P, Agaram NP, Dickson BC, Antonescu CR (2023) ALK-rearranged mesenchymal neoplasms: a report of 9 cases further expanding the clinicopathologic spectrum of emerging kinase fusion positive group of tumors. Genes Chromosomes Cancer 62(2):75–84. https://doi.org/10.1002/gcc.23097
Article CAS PubMed Google Scholar
Ravindran A, Goyal G, Go RS, Rech KL (2021) Rosai-Dorfman disease displays a unique monocyte-macrophage phenotype characterized by expression of OCT2. Am J Surg Pathol 45(1):35–44. https://doi.org/10.1097/PAS.0000000000001617
Garces S, Medeiros LJ, Patel KP, Li S, Pina-Oviedo S, Li J, Garces JC, Khoury JD, Yin CC (2017) Mutually exclusive recurrent KRAS and MAP2K1 mutations in Rosai-Dorfman disease. Mod Pathol 30(10):1367–1377. https://doi.org/10.1038/modpathol.2017.55
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