Brain Functional and Structural Changes of Breast Cancer After Chemotherapy: A Systematic Review and Meta-analysis

Ahles, T. A., Saykin, A. J., McDonald, B. C., Li, Y., Furstenberg, C. T., Hanscom, B. S., Mulrooney, T. J., Schwartz, G. N., & Kaufman, P. A. (2010). Longitudinal assessment of cognitive changes associated with adjuvant treatment for breast cancer: Impact of age and cognitive reserve. Journal of Clinical Oncology, 28(29), 4434–4440. https://doi.org/10.1200/jco.2009.27.0827

Article  PubMed  PubMed Central  Google Scholar 

Albajes-Eizagirre, A., & Radua, J. (2018). What do results from coordinate-based meta-analyses tell us? NeuroImage, 176, 550–553. https://doi.org/10.1016/j.neuroimage.2018.04.065

Article  PubMed  Google Scholar 

Albajes-Eizagirre, A., Solanes, A., Fullana, M. A., Ioannidis, J. P. A., Fusar-Poli, P., Torrent, C., Solé, B., Bonnín, C. M., Vieta, E., Mataix-Cols, D., & Radua, J. (2019a). Meta-analysis of voxel-based neuroimaging studies using seed-based d mapping with permutation of subject images (SDM-PSI). [Video]. JoVE. https://doi.org/10.3791/59841

Albajes-Eizagirre, A., Solanes, A., Vieta, E., & Radua, J. (2019b). Voxel-based meta-analysis via permutation of subject images (PSI): Theory and implementation for SDM. NeuroImage, 186, 174–184. https://doi.org/10.1016/j.neuroimage.2018.10.077

Article  PubMed  Google Scholar 

Amanzio, M., Torta, D. M. E., Sacco, K., Cauda, F., D’Agata, F., Duca, S., Leotta, D., Palermo, S., & Geminiani, G. C. (2011). Unawareness of deficits in Alzheimer’s disease: Role of the cingulate cortex. Brain : A Journal of NeuroloGy, 134(4), 1061–1076. https://doi.org/10.1093/brain/awr020

Article  PubMed  Google Scholar 

American Cancer Society. (2022). American Cancer Society. https://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/cancer-treatment-and-survivorship-facts-and-figures/2022-cancer-treatment-and-survivorship-fandf-acs.pdf. Accessed 18 Jul 2025.

Bai, X. R., Zheng, J., Zhang, B., & Luo, Y. H. (2021). Cognitive dysfunction and neurophysiologic mechanism of breast cancer patients undergoing chemotherapy based on resting state functional magnetic resonance imaging. World Neurosurgery, 149, 406–412. https://doi.org/10.1016/j.wneu.2020.10.066

Article  PubMed  Google Scholar 

Bernard, J. A., Nguyen, A. D., Hausman, H. K., Maldonado, T., Ballard, H. K., Jackson, T. B., Eakin, S. M., Lokshina, Y., & Goen, J. R. M. (2020). Shaky scaffolding: Age differences in cerebellar activation revealed through activation likelihood estimation meta-analysis. Human Brain Mapping, 41(18), 5255–5281. https://doi.org/10.1002/hbm.25191

Article  PubMed  PubMed Central  Google Scholar 

Bernstein, L. J., Edelstein, K., Sharma, A., & Alain, C. (2021). Chemo-brain: An activation likelihood estimation meta-analysis of functional magnetic resonance imaging studies. Neuroscience and Biobehavioral Reviews, 130, 314–325. https://doi.org/10.1016/j.neubiorev.2021.08.024

Article  CAS  PubMed  Google Scholar 

Billiet, T., Emsell, L., Vandenbulcke, M., Peeters, R., Christiaens, D., Leemans, A., Van Hecke, W., Smeets, A., Amant, F., Sunaert, S., & Deprez, S. (2018). Recovery from chemotherapy-induced white matter changes in young breast cancer survivors? Brain Imaging and Behavior, 12(1), 64–77. https://doi.org/10.1007/s11682-016-9665-8

Article  PubMed  Google Scholar 

Brambilla, P., Hardan, A., di Nemi, S. U., Perez, J., Soares, J. C., & Barale, F. (2003). Brain anatomy and development in autism: Review of structural MRI studies. Brain Research Bulletin, 61(6), 557–569. https://doi.org/10.1016/j.brainresbull.2003.06.001

Article  PubMed  Google Scholar 

Bray, F., Laversanne, M., Sung, H., Ferlay, J., Siegel, R. L., Soerjomataram, I., & Jemal, A. (2024). Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 74(3), 229–263. https://doi.org/10.3322/caac.21834

Article  PubMed  Google Scholar 

Butterfield, D. A. (2014). The 2013 SFRBM discovery award: Selected discoveries from the Butterfield laboratory of oxidative stress and its sequela in brain in cognitive disorders exemplified by Alzheimer disease and chemotherapy induced cognitive impairment. Free Radical Biology and MediciNe, 74, 157–174. https://doi.org/10.1016/j.freeradbiomed.2014.06.006

Article  CAS  PubMed  Google Scholar 

Cacabelos, R., Carril, J. C., Corzo, L., Pego, R., Cacabelos, N., Alcaraz, M., Muñiz, A., Martínez-Iglesias, O., & Naidoo, V. (2023). Pharmacogenetics of anxiety and depression in Alzheimer’s disease. Pharmacogenomics, 24(1), 27–57. https://doi.org/10.2217/pgs-2022-0137

Article  CAS  PubMed  Google Scholar 

Canosa, A., Palumbo, F., Iazzolino, B., Peotta, L., Di, P. F., Manera, U., Vasta, R., Grassano, M., Solero, L., Arena, V., Moglia, C., Calvo, A., Chiò, A., & Pagani, M. (2021). The interplay among education, brain metabolism, and cognitive impairment suggests a role of cognitive reserve in amyotrophic lateral sclerosis. Neurobiology of Aging, 98, 205–213. https://doi.org/10.1016/j.neurobiolaging.2020.11.010

Article  CAS  PubMed  Google Scholar 

Chapleau, M., Aldebert, J., Montembeault, M., & Brambati, S. M. (2016). Atrophy in Alzheimer’s disease and semantic dementia: An ALE meta-analysis of voxel-based morphometry studies. Journal of Alzheimer’s Disease, 54(3), 941–955. https://doi.org/10.3233/JAD-160382

Article  CAS  PubMed  Google Scholar 

Chen, B. T., Jin, T. H., Patel, S. K., Ye, N. R., Ma, H. Y., Wong, C. W., Rockne, R. C., Root, J. C., Saykin, A. J., Ahles, T. A., Holodny, A. I., Prakash, N., Mortimer, J., Waisman, J., Yuan, Y., Li, D. N., Sedrak, M. S., Vazquez, J., Katheria, V., & Dale, W. (2019a). Intrinsic brain activity changes associated with adjuvant chemotherapy in older women with breast cancer: A pilot longitudinal study. Breast Cancer Research and Treatment, 176(1), 181–189. https://doi.org/10.1007/s10549-019-05230-y

Article  PubMed  PubMed Central  Google Scholar 

Chen, B. H. T., Jin, T. H., Patel, S. K., Ye, N. R., Sun, C. L., Ma, H. Y., Rockne, R. C., Root, J. C., Saykin, A. J., Ahles, T. A., Holodny, A. I., Prakash, N., Mortimer, J., Waisman, J., Yuan, Y., Li, D. N., Somlo, G., Vazquez, J., Levi, A., … Hurria, A. (2018). Gray matter density reduction associated with adjuvant chemotherapy in older women with breast cancer. Breast Cancer Research and Treatment, 172(2), 363–370. https://doi.org/10.1007/s10549-018-4911-y

Chen, B. T., Jin, T., Patel, S. K., Ye, N., Sun, C.-L., Ma, H., Rockne, R. C., Root, J. C., Saykin, A. J., Ahles, T. A., Holodny, A. I., Prakash, N., Mortimer, J., Waisman, J., Yuan, Y., Li, D., Somlo, G., Vazquez, J., Levi, A., … Hurria, A. (2018b). Gray matter density reduction associated with adjuvant chemotherapy in older women with breast cancer. Breast Cancer Research and Treatment, 172(2), 363–370. https://doi.org/10.1007/s10549-018-4911-y

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen, Y., Lv, C., Li, X., Zhang, J., Chen, K., Liu, Z., Li, H., Fan, J., Qin, T., Luo, L., & Zhang, Z. (2019b). The positive impacts of early-life education on cognition, leisure activity, and brain structure in healthy aging. Aging, 11(14), 4923–4942. https://doi.org/10.18632/aging.102088

Article  PubMed  PubMed Central  Google Scholar 

Christopher, L., Duff-Canning, S., Koshimori, Y., Segura, B., Boileau, I., Chen, R., Lang, A. E., Houle, S., Rusjan, P., & Strafella, A. P. (2015). Salience network and parahippocampal dopamine dysfunction in memory-impaired Parkinson disease. Annals of Neurology, 77(2), 269–280. https://doi.org/10.1002/ana.24323

Article  CAS  PubMed  Google Scholar 

Conroy, S. K., McDonald, B. C., Ahles, T. A., West, J. D., & Saykin, A. J. (2013a). Chemotherapy-induced amenorrhea: A prospective study of brain activation changes and neurocognitive correlates. Brain Imaging and Behavior, 7(4), 491–500. https://doi.org/10.1007/s11682-013-9240-5

Article  PubMed  Google Scholar 

Conroy, S. K., McDonald, B. C., Smith, D. J., Moser, L. R., West, J. D., Kamendulis, L. M., Klaunig, J. E., Champion, V. L., Unverzagt, F. W., & Saykin, A. J. (2013b). Alterations in brain structure and function in breast cancer survivors: Effect of post-chemotherapy interval and relation to oxidative DNA damage. Breast Cancer Research and Treatment, 137(2), 493–502. https://doi.org/10.1007/s10549-012-2385-x

Article  CAS  PubMed  Google Scholar 

Daniel, E., Deng, F., Patel, S. K., Sedrak, M. S., Kim, H., Razavi, M., Sun, C. L., Root, J. C., Ahles, T. A., Dale, W., & Chen, B. T. (2024). Brain white matter microstructural changes in chemotherapy-treated older long-term breast cancer survivors. Cancer Medicine. https://doi.org/10.1002/cam4.6881

Article  PubMed  PubMed Central  Google Scholar 

De Ruiter, M. B., Deardorff, R. L., Blommaert, J., Chen, B. T., Dumas, J. A., Schagen, S. B., Sunaert, S., Wang, L., Cimprich, B., Peltier, S., Dittus, K., Newhouse, P. A., Silverman, D. H., Schroyen, G., Deprez, S., Saykin, A. J., & McDonald, B. C. (2023). Brain gray matter reduction and premature brain aging after breast cancer chemotherapy: A longitudinal multicenter data pooling analysis. Brain Imaging and Behavior, 17(5), 507–518. https://doi.org/10.1007/s11682-023-00781-7

Article  PubMed  PubMed Central  Google Scholar 

De Ruiter, M. B., Reneman, L., Boogerd, W., Veltman, D. J., van Dam, F., Nederveen, A. J., Boven, E., & Schagen, S. B. (2011). Cerebral hyporesponsiveness and cognitive impairment 10 years after chemotherapy for breast cancer. Human Brain Mapping, 32(8), 1206–1219. https://doi.org/10.1002/hbm.21102

Article  PubMed  Google Scholar 

Deprez, S., Amant, F., Yigit, R., Porke, K., Verhoeven, J., Van den Stock, J., Smeets, A., Christiaens, M. R., Leemans, A., Van Hecke, W., Vandenberghe, J., Vandenbulcke, M., & Sunaert, S. (2011). Chemotherapy-induced structural changes in cerebral white matter and its correlation with impaired cognitive functioning in breast cancer patients. Human Brain Mapping, 32(3), 480–493. https://doi.org/10.1002/hbm.21033

Article  PubMed  Google Scholar 

Deprez, S., Vandenbulcke, M., Peeters, R., Emsell, L., Smeets, A., Christiaens, M. R., Amant, F., & Sunaert, S. (2014). Longitudinal assessment of chemotherapy-induced alterations in brain activation during multitasking and its relation with cognitive complaints. Journal of Clinical Oncology, 32(19), 2031. https://doi.org/10.1200/JCO.2013.53.6219

Article  PubMed 

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